Alteration of specific cytokine expression patterns in patients with breast cancer

Kosuke Kawaguchi, Masashi Sakurai, Yasuko Yamamoto, Eiji Suzuki, Moe Tsuda, Tatsuki R. Kataoka, Masahiro Hirata, Mariko Nishie, Takashi Nojiri, Motofumi Kumazoe, Kuniaki Saito, Masakazu Toi

Research output: Contribution to journalArticle

Abstract

Systemic inflammation has been associated with aggressive tumor growth, invasion, and metastasis. Here we performed a comprehensive analysis of 26 kinds of inflammatory cytokine expression patterns among 185 patients with breast cancer and 54 healthy volunteers followed by chemometric analysis. We identified the specific cytokine expression patterns of breast cancer patients compared to healthy volunteers with (1) VEGF, IL-9, GM-CSF, IL-13, IL-4, and IFNγ, (2) IL-8, IL-10, IL-12, IL-5, IL-7, IL-1α, GCSF, IL-1β, and TNFα and (3) IL-2, Eotaxin, MIP1β, MIP1α, IL-17, and bFGF. Among the patients with breast cancer, we identified the specific cytokine signature of metastatic patients compared to non-metastatic patients. We also established a mathematical model for distinguishing patients with breast cancer from healthy volunteers and metastatic patients from non-metastatic patients. This cytokine network analysis could provide new insights into early intervention and effective therapeutic strategy for patients with breast cancer.

Original languageEnglish
Article number2924
JournalScientific Reports
Volume9
Issue number1
DOIs
Publication statusPublished - 01-12-2019

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Breast Neoplasms
Cytokines
Healthy Volunteers
Interleukin-1
Interleukin-9
Interleukin-7
Interleukin-13
Interleukin-17
Interleukin-5
Interleukin-12
Granulocyte-Macrophage Colony-Stimulating Factor
Interleukin-8
Interleukin-4
Interleukin-10
Vascular Endothelial Growth Factor A
Interleukin-2
Theoretical Models
Neoplasm Metastasis
Inflammation
Growth

All Science Journal Classification (ASJC) codes

  • General

Cite this

Kawaguchi, K., Sakurai, M., Yamamoto, Y., Suzuki, E., Tsuda, M., Kataoka, T. R., ... Toi, M. (2019). Alteration of specific cytokine expression patterns in patients with breast cancer. Scientific Reports, 9(1), [2924]. https://doi.org/10.1038/s41598-019-39476-9
Kawaguchi, Kosuke ; Sakurai, Masashi ; Yamamoto, Yasuko ; Suzuki, Eiji ; Tsuda, Moe ; Kataoka, Tatsuki R. ; Hirata, Masahiro ; Nishie, Mariko ; Nojiri, Takashi ; Kumazoe, Motofumi ; Saito, Kuniaki ; Toi, Masakazu. / Alteration of specific cytokine expression patterns in patients with breast cancer. In: Scientific Reports. 2019 ; Vol. 9, No. 1.
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Kawaguchi, K, Sakurai, M, Yamamoto, Y, Suzuki, E, Tsuda, M, Kataoka, TR, Hirata, M, Nishie, M, Nojiri, T, Kumazoe, M, Saito, K & Toi, M 2019, 'Alteration of specific cytokine expression patterns in patients with breast cancer', Scientific Reports, vol. 9, no. 1, 2924. https://doi.org/10.1038/s41598-019-39476-9

Alteration of specific cytokine expression patterns in patients with breast cancer. / Kawaguchi, Kosuke; Sakurai, Masashi; Yamamoto, Yasuko; Suzuki, Eiji; Tsuda, Moe; Kataoka, Tatsuki R.; Hirata, Masahiro; Nishie, Mariko; Nojiri, Takashi; Kumazoe, Motofumi; Saito, Kuniaki; Toi, Masakazu.

In: Scientific Reports, Vol. 9, No. 1, 2924, 01.12.2019.

Research output: Contribution to journalArticle

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AU - Saito, Kuniaki

AU - Toi, Masakazu

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