Alterations in Cognition-Related Cerebello-Cerebral Networks in Multiple System Atrophy

Kazuya Kawabata, Kazuhiro Hara, Hirohisa Watanabe, Epifanio Bagarinao, Aya Ogura, Michihito Masuda, Takamasa Yokoi, Toshiyasu Kato, Reiko Ohdake, Mizuki Ito, Masahisa Katsuno, Gen Sobue

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3 Citations (Scopus)

Abstract

We aimed to elucidate the effect of cerebellar degeneration in relation to cognition in multiple system atrophy (MSA). Thirty-two patients diagnosed with probable MSA and 32 age- and gender-matched healthy controls (HCs) were enrolled. We conducted voxel-based morphometry (VBM) for anatomical images and independent component analysis (ICA), dual-regression analysis, and seed-based analysis for functional images with voxel-wise gray matter correction. In the MSA group, a widespread cerebellar volume loss was observed. ICA and dual-regression analysis showed lower functional connectivity (FC) in the left executive control and salience networks in regions located in the cerebellum. Seed-based analysis using the identified cerebellar regions as seeds showed extensive disruptions in cerebello-cerebral networks. Global cognitive scores correlated with the FC values between the right lobules VI/crus I and the medial prefrontal/anterior cingulate cortices and between the same region and the amygdala/parahippocampal gyrus. Our study indicates that cerebellar degeneration in MSA causes segregation of cerebellar-cerebral networks. Furthermore, the cognitive deficits in MSA may be driven by decreased cerebello-prefrontal and cerebello-amygdaloid functional connections.

Original languageEnglish
Pages (from-to)770-780
Number of pages11
JournalCerebellum
Volume18
Issue number4
DOIs
Publication statusPublished - 15-08-2019
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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  • Cite this

    Kawabata, K., Hara, K., Watanabe, H., Bagarinao, E., Ogura, A., Masuda, M., Yokoi, T., Kato, T., Ohdake, R., Ito, M., Katsuno, M., & Sobue, G. (2019). Alterations in Cognition-Related Cerebello-Cerebral Networks in Multiple System Atrophy. Cerebellum, 18(4), 770-780. https://doi.org/10.1007/s12311-019-01031-7