Abstract
Genomic imprinting is defined as a gamete-specific modification causing differential expression of the two alleles of a gene in somatic cells. While insulin-like growth factor 2 (IGF2) and H19 both at 11p15 are imprinted in normal lung, we observed frequent loss of imprinting (LOI) of the IGF2 and H19 genes in the lung cancer. While genomic imprinting is thought to play an important role in embryonal development and possibly in the development of certain embryonal tumors such as Wilms' tumor, these results suggest that altered imprinting may also play a role in the oncogenesis of this common cancer of adults, lung cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 492-496 |
| Number of pages | 5 |
| Journal | Nippon rinsho. Japanese journal of clinical medicine |
| Volume | 54 |
| Issue number | 2 |
| Publication status | Published - 01-01-1996 |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
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Altered genomic imprinting in the IGF2 and H19 genes in human lung cancer. / Kondo, Masashi; Takahashi, T.
In: Nippon rinsho. Japanese journal of clinical medicine, Vol. 54, No. 2, 01.01.1996, p. 492-496.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Altered genomic imprinting in the IGF2 and H19 genes in human lung cancer
AU - Kondo, Masashi
AU - Takahashi, T.
PY - 1996/1/1
Y1 - 1996/1/1
N2 - Genomic imprinting is defined as a gamete-specific modification causing differential expression of the two alleles of a gene in somatic cells. While insulin-like growth factor 2 (IGF2) and H19 both at 11p15 are imprinted in normal lung, we observed frequent loss of imprinting (LOI) of the IGF2 and H19 genes in the lung cancer. While genomic imprinting is thought to play an important role in embryonal development and possibly in the development of certain embryonal tumors such as Wilms' tumor, these results suggest that altered imprinting may also play a role in the oncogenesis of this common cancer of adults, lung cancer.
AB - Genomic imprinting is defined as a gamete-specific modification causing differential expression of the two alleles of a gene in somatic cells. While insulin-like growth factor 2 (IGF2) and H19 both at 11p15 are imprinted in normal lung, we observed frequent loss of imprinting (LOI) of the IGF2 and H19 genes in the lung cancer. While genomic imprinting is thought to play an important role in embryonal development and possibly in the development of certain embryonal tumors such as Wilms' tumor, these results suggest that altered imprinting may also play a role in the oncogenesis of this common cancer of adults, lung cancer.
UR - http://www.scopus.com/inward/record.url?scp=0030074674&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030074674&partnerID=8YFLogxK
M3 - Review article
C2 - 8838103
AN - SCOPUS:0030074674
VL - 54
SP - 492
EP - 496
JO - Nippon rinsho. Japanese journal of clinical medicine
JF - Nippon rinsho. Japanese journal of clinical medicine
SN - 0047-1852
IS - 2
ER -