Altered genomic imprinting in the IGF2 and H19 genes in human lung cancer

Masashi Kondo, T. Takahashi

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Genomic imprinting is defined as a gamete-specific modification causing differential expression of the two alleles of a gene in somatic cells. While insulin-like growth factor 2 (IGF2) and H19 both at 11p15 are imprinted in normal lung, we observed frequent loss of imprinting (LOI) of the IGF2 and H19 genes in the lung cancer. While genomic imprinting is thought to play an important role in embryonal development and possibly in the development of certain embryonal tumors such as Wilms' tumor, these results suggest that altered imprinting may also play a role in the oncogenesis of this common cancer of adults, lung cancer.

Original languageEnglish
Pages (from-to)492-496
Number of pages5
JournalNippon rinsho. Japanese journal of clinical medicine
Volume54
Issue number2
Publication statusPublished - 01-01-1996

Fingerprint

Genomic Imprinting
Somatomedins
Lung Neoplasms
Genes
Wilms Tumor
Germ Cells
Carcinogenesis
Alleles
Lung
Neoplasms

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

@article{edee7a2f129a4122bef3561fa491483d,
title = "Altered genomic imprinting in the IGF2 and H19 genes in human lung cancer",
abstract = "Genomic imprinting is defined as a gamete-specific modification causing differential expression of the two alleles of a gene in somatic cells. While insulin-like growth factor 2 (IGF2) and H19 both at 11p15 are imprinted in normal lung, we observed frequent loss of imprinting (LOI) of the IGF2 and H19 genes in the lung cancer. While genomic imprinting is thought to play an important role in embryonal development and possibly in the development of certain embryonal tumors such as Wilms' tumor, these results suggest that altered imprinting may also play a role in the oncogenesis of this common cancer of adults, lung cancer.",
author = "Masashi Kondo and T. Takahashi",
year = "1996",
month = "1",
day = "1",
language = "English",
volume = "54",
pages = "492--496",
journal = "Nippon rinsho. Japanese journal of clinical medicine",
issn = "0047-1852",
publisher = "Nipponrinsho Co., Inc.",
number = "2",

}

Altered genomic imprinting in the IGF2 and H19 genes in human lung cancer. / Kondo, Masashi; Takahashi, T.

In: Nippon rinsho. Japanese journal of clinical medicine, Vol. 54, No. 2, 01.01.1996, p. 492-496.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Altered genomic imprinting in the IGF2 and H19 genes in human lung cancer

AU - Kondo, Masashi

AU - Takahashi, T.

PY - 1996/1/1

Y1 - 1996/1/1

N2 - Genomic imprinting is defined as a gamete-specific modification causing differential expression of the two alleles of a gene in somatic cells. While insulin-like growth factor 2 (IGF2) and H19 both at 11p15 are imprinted in normal lung, we observed frequent loss of imprinting (LOI) of the IGF2 and H19 genes in the lung cancer. While genomic imprinting is thought to play an important role in embryonal development and possibly in the development of certain embryonal tumors such as Wilms' tumor, these results suggest that altered imprinting may also play a role in the oncogenesis of this common cancer of adults, lung cancer.

AB - Genomic imprinting is defined as a gamete-specific modification causing differential expression of the two alleles of a gene in somatic cells. While insulin-like growth factor 2 (IGF2) and H19 both at 11p15 are imprinted in normal lung, we observed frequent loss of imprinting (LOI) of the IGF2 and H19 genes in the lung cancer. While genomic imprinting is thought to play an important role in embryonal development and possibly in the development of certain embryonal tumors such as Wilms' tumor, these results suggest that altered imprinting may also play a role in the oncogenesis of this common cancer of adults, lung cancer.

UR - http://www.scopus.com/inward/record.url?scp=0030074674&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030074674&partnerID=8YFLogxK

M3 - Review article

C2 - 8838103

AN - SCOPUS:0030074674

VL - 54

SP - 492

EP - 496

JO - Nippon rinsho. Japanese journal of clinical medicine

JF - Nippon rinsho. Japanese journal of clinical medicine

SN - 0047-1852

IS - 2

ER -