Altered genomic imprinting in the IGF2 and H19 genes in human lung cancer

M. Kondo, T. Takahashi

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12 Citations (Scopus)


Genomic imprinting is defined as a gamete-specific modification causing differential expression of the two alleles of a gene in somatic cells. While insulin-like growth factor 2 (IGF2) and H19 both at 11p15 are imprinted in normal lung, we observed frequent loss of imprinting (LOI) of the IGF2 and H19 genes in the lung cancer. While genomic imprinting is thought to play an important role in embryonal development and possibly in the development of certain embryonal tumors such as Wilms' tumor, these results suggest that altered imprinting may also play a role in the oncogenesis of this common cancer of adults, lung cancer.

Original languageEnglish
Pages (from-to)492-496
Number of pages5
JournalNippon rinsho. Japanese journal of clinical medicine
Issue number2
Publication statusPublished - 02-1996
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Medicine


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