Amelanotic Malignant Melanoma with a BRAF V600E Mutation Mimicking Primary Lung Cancer

Reiko Matsuzawa; Masahiro Morise; Ichidai Tanaka; Shunsaku Hayai; Yutaro Tamiya; Junji Koyama; Tetsunari Hase; Keiko Wakahara; Deoksu Kim; Yoshie Shimoyama; Naozumi Hashimoto

doi:10.2169/internalmedicine.6657-20

Amelanotic Malignant Melanoma with a BRAF V600E Mutation Mimicking Primary Lung Cancer

Reiko Matsuzawa, Masahiro Morise, Ichidai Tanaka, Shunsaku Hayai, Yutaro Tamiya, Junji Koyama, Tetsunari Hase, Keiko Wakahara, Deoksu Kim, Yoshie Shimoyama, Naozumi Hashimoto

Research output: Contribution to journal › Article › peer-review

Abstract

Amelanotic melanoma is a rare type of melanoma that shows little or no melanin pigmentation. When tumor lesions are not detected in cutaneous sites, the presence of melanin is the hallmark sign of malignant melanoma. We herein report a case of amelanotic melanoma with a BRAF V600E mutation mimicking primary lung cancer that was finally diagnosed on an autopsy. The current case suggests important caveats for the differential diagnosis of patients with BRAF V600E mutation-positive poorly differentiated lung tumors. In terms of the pathological diagnosis, routine immunohistochemical staining may be useful, especially in patients with a poorly differentiated lung tumor without TTF-1 expression.

Original language	English
Pages (from-to)	703-708
Number of pages	6
Journal	Internal Medicine
Volume	61
Issue number	5
DOIs	https://doi.org/10.2169/internalmedicine.6657-20
Publication status	Published - 2022
Externally published	Yes

All Science Journal Classification (ASJC) codes

Internal Medicine

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10.2169/internalmedicine.6657-20

Cite this

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title = "Amelanotic Malignant Melanoma with a BRAF V600E Mutation Mimicking Primary Lung Cancer",

abstract = "Amelanotic melanoma is a rare type of melanoma that shows little or no melanin pigmentation. When tumor lesions are not detected in cutaneous sites, the presence of melanin is the hallmark sign of malignant melanoma. We herein report a case of amelanotic melanoma with a BRAF V600E mutation mimicking primary lung cancer that was finally diagnosed on an autopsy. The current case suggests important caveats for the differential diagnosis of patients with BRAF V600E mutation-positive poorly differentiated lung tumors. In terms of the pathological diagnosis, routine immunohistochemical staining may be useful, especially in patients with a poorly differentiated lung tumor without TTF-1 expression.",

author = "Reiko Matsuzawa and Masahiro Morise and Ichidai Tanaka and Shunsaku Hayai and Yutaro Tamiya and Junji Koyama and Tetsunari Hase and Keiko Wakahara and Deoksu Kim and Yoshie Shimoyama and Naozumi Hashimoto",

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doi = "10.2169/internalmedicine.6657-20",

language = "English",

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T1 - Amelanotic Malignant Melanoma with a BRAF V600E Mutation Mimicking Primary Lung Cancer

AU - Matsuzawa, Reiko

AU - Morise, Masahiro

AU - Tanaka, Ichidai

AU - Hayai, Shunsaku

AU - Tamiya, Yutaro

AU - Koyama, Junji

AU - Hase, Tetsunari

AU - Wakahara, Keiko

AU - Kim, Deoksu

AU - Shimoyama, Yoshie

AU - Hashimoto, Naozumi

PY - 2022

Y1 - 2022

N2 - Amelanotic melanoma is a rare type of melanoma that shows little or no melanin pigmentation. When tumor lesions are not detected in cutaneous sites, the presence of melanin is the hallmark sign of malignant melanoma. We herein report a case of amelanotic melanoma with a BRAF V600E mutation mimicking primary lung cancer that was finally diagnosed on an autopsy. The current case suggests important caveats for the differential diagnosis of patients with BRAF V600E mutation-positive poorly differentiated lung tumors. In terms of the pathological diagnosis, routine immunohistochemical staining may be useful, especially in patients with a poorly differentiated lung tumor without TTF-1 expression.

AB - Amelanotic melanoma is a rare type of melanoma that shows little or no melanin pigmentation. When tumor lesions are not detected in cutaneous sites, the presence of melanin is the hallmark sign of malignant melanoma. We herein report a case of amelanotic melanoma with a BRAF V600E mutation mimicking primary lung cancer that was finally diagnosed on an autopsy. The current case suggests important caveats for the differential diagnosis of patients with BRAF V600E mutation-positive poorly differentiated lung tumors. In terms of the pathological diagnosis, routine immunohistochemical staining may be useful, especially in patients with a poorly differentiated lung tumor without TTF-1 expression.

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Amelanotic Malignant Melanoma with a BRAF V600E Mutation Mimicking Primary Lung Cancer

Abstract

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