Amelanotic Malignant Melanoma with a BRAF V600E Mutation Mimicking Primary Lung Cancer

Reiko Matsuzawa, Masahiro Morise, Ichidai Tanaka, Shunsaku Hayai, Yutaro Tamiya, Junji Koyama, Tetsunari Hase, Keiko Wakahara, Deoksu Kim, Yoshie Shimoyama, Naozumi Hashimoto

Research output: Contribution to journalArticlepeer-review


Amelanotic melanoma is a rare type of melanoma that shows little or no melanin pigmentation. When tumor lesions are not detected in cutaneous sites, the presence of melanin is the hallmark sign of malignant melanoma. We herein report a case of amelanotic melanoma with a BRAF V600E mutation mimicking primary lung cancer that was finally diagnosed on an autopsy. The current case suggests important caveats for the differential diagnosis of patients with BRAF V600E mutation-positive poorly differentiated lung tumors. In terms of the pathological diagnosis, routine immunohistochemical staining may be useful, especially in patients with a poorly differentiated lung tumor without TTF-1 expression.

Original languageEnglish
Pages (from-to)703-708
Number of pages6
JournalInternal Medicine
Issue number5
Publication statusPublished - 2022
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Internal Medicine


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