Amines and pteridines

K. Shimpo, T. Chihara, M. Hibiya, S. Ito, T. Nagatsu

Research output: Contribution to journalReview article


Polyamines (putrescine, spermidine and spermine) play important roles in cell proliferation and differentiation, and have been established as tumors markers. We and other workers have confirmed that N1-acetylspermidine in tumor tissues, spermidine and spermine in erythrocytes, and N1,N12-diacetylspermine in urine might be the most sensitive indicators for various forms of tumors. Neopterin is a marker of cell-mediated immunostimulation, and may be a helpful marker in monitoring cancer patients. HPLC and immunological assays of neopterin, biopterin, and N2-(3-aminopropyl)biopterin(oncopterin) in urine might be useful in the clinical study of pteridines, as cancer markers. Serum 5-S-cysteinyldopa level is a useful and specific biochemical marker for malignant melanoma.

Original languageEnglish
Pages (from-to)1515-1520
Number of pages6
JournalNippon rinsho. Japanese journal of clinical medicine
Issue number6
Publication statusPublished - 06-1996

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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    Shimpo, K., Chihara, T., Hibiya, M., Ito, S., & Nagatsu, T. (1996). Amines and pteridines. Nippon rinsho. Japanese journal of clinical medicine, 54(6), 1515-1520.