Amines and pteridines

K. Shimpo, T. Chihara, M. Hibiya, S. Ito, T. Nagatsu

Research output: Contribution to journalReview articlepeer-review


Polyamines (putrescine, spermidine and spermine) play important roles in cell proliferation and differentiation, and have been established as tumors markers. We and other workers have confirmed that N1-acetylspermidine in tumor tissues, spermidine and spermine in erythrocytes, and N1,N12-diacetylspermine in urine might be the most sensitive indicators for various forms of tumors. Neopterin is a marker of cell-mediated immunostimulation, and may be a helpful marker in monitoring cancer patients. HPLC and immunological assays of neopterin, biopterin, and N2-(3-aminopropyl)biopterin(oncopterin) in urine might be useful in the clinical study of pteridines, as cancer markers. Serum 5-S-cysteinyldopa level is a useful and specific biochemical marker for malignant melanoma.

Original languageEnglish
Pages (from-to)1515-1520
Number of pages6
JournalNippon rinsho. Japanese journal of clinical medicine
Issue number6
Publication statusPublished - 06-1996

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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