Amines and pteridines

K. Shimpo, Takeshi Chihara, M. Hibiya, S. Ito, T. Nagatsu

Research output: Contribution to journalReview article

Abstract

Polyamines (putrescine, spermidine and spermine) play important roles in cell proliferation and differentiation, and have been established as tumors markers. We and other workers have confirmed that N1-acetylspermidine in tumor tissues, spermidine and spermine in erythrocytes, and N1,N12-diacetylspermine in urine might be the most sensitive indicators for various forms of tumors. Neopterin is a marker of cell-mediated immunostimulation, and may be a helpful marker in monitoring cancer patients. HPLC and immunological assays of neopterin, biopterin, and N2-(3-aminopropyl)biopterin(oncopterin) in urine might be useful in the clinical study of pteridines, as cancer markers. Serum 5-S-cysteinyldopa level is a useful and specific biochemical marker for malignant melanoma.

Original languageEnglish
Pages (from-to)1515-1520
Number of pages6
JournalNippon rinsho. Japanese journal of clinical medicine
Volume54
Issue number6
Publication statusPublished - 01-01-1996

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Pteridines
Amines
Biopterin
Neopterin
Spermidine
Spermine
Neoplasms
Cysteinyldopa
Urine
Putrescine
Polyamines
Physiologic Monitoring
Tumor Biomarkers
Cell Differentiation
Melanoma
Immunization
Erythrocytes
Biomarkers
High Pressure Liquid Chromatography
Cell Proliferation

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Shimpo, K., Chihara, T., Hibiya, M., Ito, S., & Nagatsu, T. (1996). Amines and pteridines. Nippon rinsho. Japanese journal of clinical medicine, 54(6), 1515-1520.
Shimpo, K. ; Chihara, Takeshi ; Hibiya, M. ; Ito, S. ; Nagatsu, T. / Amines and pteridines. In: Nippon rinsho. Japanese journal of clinical medicine. 1996 ; Vol. 54, No. 6. pp. 1515-1520.
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Shimpo, K, Chihara, T, Hibiya, M, Ito, S & Nagatsu, T 1996, 'Amines and pteridines', Nippon rinsho. Japanese journal of clinical medicine, vol. 54, no. 6, pp. 1515-1520.

Amines and pteridines. / Shimpo, K.; Chihara, Takeshi; Hibiya, M.; Ito, S.; Nagatsu, T.

In: Nippon rinsho. Japanese journal of clinical medicine, Vol. 54, No. 6, 01.01.1996, p. 1515-1520.

Research output: Contribution to journalReview article

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T1 - Amines and pteridines

AU - Shimpo, K.

AU - Chihara, Takeshi

AU - Hibiya, M.

AU - Ito, S.

AU - Nagatsu, T.

PY - 1996/1/1

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AB - Polyamines (putrescine, spermidine and spermine) play important roles in cell proliferation and differentiation, and have been established as tumors markers. We and other workers have confirmed that N1-acetylspermidine in tumor tissues, spermidine and spermine in erythrocytes, and N1,N12-diacetylspermine in urine might be the most sensitive indicators for various forms of tumors. Neopterin is a marker of cell-mediated immunostimulation, and may be a helpful marker in monitoring cancer patients. HPLC and immunological assays of neopterin, biopterin, and N2-(3-aminopropyl)biopterin(oncopterin) in urine might be useful in the clinical study of pteridines, as cancer markers. Serum 5-S-cysteinyldopa level is a useful and specific biochemical marker for malignant melanoma.

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Shimpo K, Chihara T, Hibiya M, Ito S, Nagatsu T. Amines and pteridines. Nippon rinsho. Japanese journal of clinical medicine. 1996 Jan 1;54(6):1515-1520.