Aminoglycoside Resistance: The Emergence of Acquired 16S Ribosomal RNA Methyltransferases

Yohei Doi, Jun ichi Wachino, Yoshichika Arakawa

Research output: Contribution to journalReview article

73 Citations (Scopus)

Abstract

Aminoglycoside-producing Actinobacteria are known to protect themselves from their own aminoglycoside metabolites by producing 16S ribosomal RNA methyltransferase (16S-RMTase), which prevents them from binding to the 16S rRNA targets. Ten acquired 16S-RMTases have been reported from gram-negative pathogens. Most of them posttranscriptionally methylate residue G1405 of 16S rRNA resulting in high-level resistance to gentamicin, tobramycin, amikacin, and plazomicin. Strains that produce 16S-RMTase are frequently multidrug-resistant or even extensively drug-resistant. Although the direct clinical impact of high-level aminoglycoside resistance resulting from production of 16S-RMTase is yet to be determined, ongoing spread of this mechanism will further limit treatment options for multidrug-resistant and extensively drug-resistant gram-negative infections.

Original languageEnglish
Pages (from-to)523-537
Number of pages15
JournalInfectious Disease Clinics of North America
Volume30
Issue number2
DOIs
Publication statusPublished - 01-06-2016
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

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