Aminoglycoside Resistance: Updates with a Focus on Acquired 16S Ribosomal RNA Methyltransferases

Jun Ichi Wachino, Yohei Doi, Yoshichika Arakawa

Research output: Contribution to journalReview articlepeer-review

35 Citations (Scopus)


The clinical usefulness of aminoglycosides has been revisited as an effective choice against β-lactam–resistant and fluoroquinolone-resistant gram-negative bacterial infections. Plazomicin, a next-generation aminoglycoside, was introduced for the treatment of complicated urinary tract infections and acute pyelonephritis. In contrast, bacteria have resisted aminoglycosides, including plazomicin, by producing 16S ribosomal RNA (rRNA) methyltransferases (MTases) that confer high-level and broad-range aminoglycoside resistance. Aminoglycoside-resistant 16S rRNA MTase-producing gram-negative pathogens are widespread in various settings and are becoming a grave concern. This article provides up-to-date information with a focus on aminoglycoside-resistant 16S rRNA MTases.

Original languageEnglish
Pages (from-to)887-902
Number of pages16
JournalInfectious Disease Clinics of North America
Issue number4
Publication statusPublished - 12-2020

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases


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