Amplification and overexpression of c-met gene in Epstein-Barr virus-associated gastric carcinomas

Yuko Kijima, Shuichi Hokita, Heiji Yoshinaka, Tetsuhiko Itoh, Chihaya Koriyama, Yoshito Eizuru, Suminori Akiba, Takashi Aikou

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

To reveal the role of oncogenes in Epstein-Barr virus (EBV)-positive gastric carcinomas, the amplification and overexpression of the c-met gene were examined by a competitive polymerase chain reaction and immunohistochemistry, respectively. The proportion of c-met amplification and overexpression in EBV-positive and -negative carcinomas did not differ significantly. The amplification and overexpression of the c-met gene in EBV-negative gastric carcinomas were significantly associated with upper location, deeper invasion and lymphatic invasion, while in EBV-positive gastric carcinomas a significant correlation with c-met activation was observed only in deeper invasion. However, none of the observed associations of c-met amplification or overexpression with clinicopathological features in the EBV-positive and -negative carcinomas differed significantly in their strength or direction. These results suggest that the amplification and overexpression of c-met gene do not play a different role in the progression and metastasis of EBV-positive and EBV-negative gastric carcinomas.

Original languageEnglish
Pages (from-to)60-65
Number of pages6
JournalOncology
Volume62
Issue number1
DOIs
Publication statusPublished - 14-02-2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Amplification and overexpression of c-met gene in Epstein-Barr virus-associated gastric carcinomas'. Together they form a unique fingerprint.

Cite this