Amplified association between blood pressure and albuminuria in overweight patients with biopsy-proven hypertensive nephrosclerosis

Research Group of Diabetic Nephropathy and Nephrosclerosis, Ministry of Health, Labour and Welfare of Japan, Japan Agency for Medical Research and Development

Research output: Contribution to journalArticle

Abstract

BACKGROUND An overweight person is at high risk for hypertensive renal damage. The effect of weight on the association between systolic blood pressure (SBP) and albuminuria remains unknown in patients with histologically diagnosed hypertensive nephrosclerosis. METHODS A total of 97 patients with biopsy-confirmed hypertensive nephrosclerosis were recruited from 13 centers throughout Japan. We examined the relationship between SBP and proteinuria among those who were overweight, which is defined as a body mass index ≥25 kg/m2, and those who were not. We examined the interaction of weight and SBP with albuminuria at baseline and with the changes in estimated glomerular filtration rate (eGFR) during the observational period. RESULTS Our results included mean age (54 years old), blood pressure (138/80), eGFR (53 ml/min/1.73 m2), and urine albumin levels (0.2 g/day). SBP was significantly correlated with log-transformed urine albumin levels (r = 0.4, P = 0.01) in patients who were overweight (n = 38) compared with patients who were not overweight (n = 59). Multiple regression analysis revealed that the interaction between being overweight and SBP with respect to albuminuria was significantly correlated with the log-transformed urine albumin level (β = 0.39, P = 0.047) and was independent of age, sex, and potential confounding factors. The interaction between weight and SBP ≥140 mm Hg was significantly associated with a greater decrease in eGFR in the following 3 years. CONCLUSIONS Being overweight may enhance susceptibility to hypertensive glomerular damage and may eventually lead to renal progression in patients with hypertensive nephrosclerosis.

Original languageEnglish
Pages (from-to)486-491
Number of pages6
JournalAmerican Journal of Hypertension
Volume32
Issue number5
DOIs
Publication statusPublished - 01-01-2019

Fingerprint

Nephrosclerosis
Albuminuria
Blood Pressure
Biopsy
Glomerular Filtration Rate
Albumins
Urine
Weights and Measures
Kidney
Proteinuria

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Research Group of Diabetic Nephropathy and Nephrosclerosis, Ministry of Health, Labour and Welfare of Japan, & Japan Agency for Medical Research and Development (2019). Amplified association between blood pressure and albuminuria in overweight patients with biopsy-proven hypertensive nephrosclerosis. American Journal of Hypertension, 32(5), 486-491. https://doi.org/10.1093/ajh/hpz010
Research Group of Diabetic Nephropathy and Nephrosclerosis ; Ministry of Health, Labour and Welfare of Japan ; Japan Agency for Medical Research and Development. / Amplified association between blood pressure and albuminuria in overweight patients with biopsy-proven hypertensive nephrosclerosis. In: American Journal of Hypertension. 2019 ; Vol. 32, No. 5. pp. 486-491.
@article{d5416ffbccb347619b5e8dfb0e9d21d9,
title = "Amplified association between blood pressure and albuminuria in overweight patients with biopsy-proven hypertensive nephrosclerosis",
abstract = "BACKGROUND An overweight person is at high risk for hypertensive renal damage. The effect of weight on the association between systolic blood pressure (SBP) and albuminuria remains unknown in patients with histologically diagnosed hypertensive nephrosclerosis. METHODS A total of 97 patients with biopsy-confirmed hypertensive nephrosclerosis were recruited from 13 centers throughout Japan. We examined the relationship between SBP and proteinuria among those who were overweight, which is defined as a body mass index ≥25 kg/m2, and those who were not. We examined the interaction of weight and SBP with albuminuria at baseline and with the changes in estimated glomerular filtration rate (eGFR) during the observational period. RESULTS Our results included mean age (54 years old), blood pressure (138/80), eGFR (53 ml/min/1.73 m2), and urine albumin levels (0.2 g/day). SBP was significantly correlated with log-transformed urine albumin levels (r = 0.4, P = 0.01) in patients who were overweight (n = 38) compared with patients who were not overweight (n = 59). Multiple regression analysis revealed that the interaction between being overweight and SBP with respect to albuminuria was significantly correlated with the log-transformed urine albumin level (β = 0.39, P = 0.047) and was independent of age, sex, and potential confounding factors. The interaction between weight and SBP ≥140 mm Hg was significantly associated with a greater decrease in eGFR in the following 3 years. CONCLUSIONS Being overweight may enhance susceptibility to hypertensive glomerular damage and may eventually lead to renal progression in patients with hypertensive nephrosclerosis.",
author = "{Research Group of Diabetic Nephropathy and Nephrosclerosis} and {Ministry of Health, Labour and Welfare of Japan} and {Japan Agency for Medical Research and Development} and Kentaro Kohagura and Kengo Furuichi and Masako Kochi and Miho Shimizu and Yukio Yuzawa and Akinori Hara and Tadashi Toyama and Hiroshi Kitamura and Yoshiki Suzuki and Hiroshi Sato and Noriko Uesugi and Yoshifumi Ubara and Junichi Hoshino and Yukio Yuzawa and Yoshihiko Ueda and Shinichi Nishi and Hitoshi Yokoyama and Tomoya Nishino and Daisuke Ogawa and Koki Mise and Yugo Shibagaki and Kenjiro Kimura and Masakazu Haneda and Hirofumi Makino and Seiichi Matsuo and Takashi Wada",
year = "2019",
month = "1",
day = "1",
doi = "10.1093/ajh/hpz010",
language = "English",
volume = "32",
pages = "486--491",
journal = "American Journal of Hypertension",
issn = "0895-7061",
publisher = "Oxford University Press",
number = "5",

}

Research Group of Diabetic Nephropathy and Nephrosclerosis, Ministry of Health, Labour and Welfare of Japan & Japan Agency for Medical Research and Development 2019, 'Amplified association between blood pressure and albuminuria in overweight patients with biopsy-proven hypertensive nephrosclerosis', American Journal of Hypertension, vol. 32, no. 5, pp. 486-491. https://doi.org/10.1093/ajh/hpz010

Amplified association between blood pressure and albuminuria in overweight patients with biopsy-proven hypertensive nephrosclerosis. / Research Group of Diabetic Nephropathy and Nephrosclerosis; Ministry of Health, Labour and Welfare of Japan; Japan Agency for Medical Research and Development.

In: American Journal of Hypertension, Vol. 32, No. 5, 01.01.2019, p. 486-491.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Amplified association between blood pressure and albuminuria in overweight patients with biopsy-proven hypertensive nephrosclerosis

AU - Research Group of Diabetic Nephropathy and Nephrosclerosis

AU - Ministry of Health, Labour and Welfare of Japan

AU - Japan Agency for Medical Research and Development

AU - Kohagura, Kentaro

AU - Furuichi, Kengo

AU - Kochi, Masako

AU - Shimizu, Miho

AU - Yuzawa, Yukio

AU - Hara, Akinori

AU - Toyama, Tadashi

AU - Kitamura, Hiroshi

AU - Suzuki, Yoshiki

AU - Sato, Hiroshi

AU - Uesugi, Noriko

AU - Ubara, Yoshifumi

AU - Hoshino, Junichi

AU - Yuzawa, Yukio

AU - Ueda, Yoshihiko

AU - Nishi, Shinichi

AU - Yokoyama, Hitoshi

AU - Nishino, Tomoya

AU - Ogawa, Daisuke

AU - Mise, Koki

AU - Shibagaki, Yugo

AU - Kimura, Kenjiro

AU - Haneda, Masakazu

AU - Makino, Hirofumi

AU - Matsuo, Seiichi

AU - Wada, Takashi

PY - 2019/1/1

Y1 - 2019/1/1

N2 - BACKGROUND An overweight person is at high risk for hypertensive renal damage. The effect of weight on the association between systolic blood pressure (SBP) and albuminuria remains unknown in patients with histologically diagnosed hypertensive nephrosclerosis. METHODS A total of 97 patients with biopsy-confirmed hypertensive nephrosclerosis were recruited from 13 centers throughout Japan. We examined the relationship between SBP and proteinuria among those who were overweight, which is defined as a body mass index ≥25 kg/m2, and those who were not. We examined the interaction of weight and SBP with albuminuria at baseline and with the changes in estimated glomerular filtration rate (eGFR) during the observational period. RESULTS Our results included mean age (54 years old), blood pressure (138/80), eGFR (53 ml/min/1.73 m2), and urine albumin levels (0.2 g/day). SBP was significantly correlated with log-transformed urine albumin levels (r = 0.4, P = 0.01) in patients who were overweight (n = 38) compared with patients who were not overweight (n = 59). Multiple regression analysis revealed that the interaction between being overweight and SBP with respect to albuminuria was significantly correlated with the log-transformed urine albumin level (β = 0.39, P = 0.047) and was independent of age, sex, and potential confounding factors. The interaction between weight and SBP ≥140 mm Hg was significantly associated with a greater decrease in eGFR in the following 3 years. CONCLUSIONS Being overweight may enhance susceptibility to hypertensive glomerular damage and may eventually lead to renal progression in patients with hypertensive nephrosclerosis.

AB - BACKGROUND An overweight person is at high risk for hypertensive renal damage. The effect of weight on the association between systolic blood pressure (SBP) and albuminuria remains unknown in patients with histologically diagnosed hypertensive nephrosclerosis. METHODS A total of 97 patients with biopsy-confirmed hypertensive nephrosclerosis were recruited from 13 centers throughout Japan. We examined the relationship between SBP and proteinuria among those who were overweight, which is defined as a body mass index ≥25 kg/m2, and those who were not. We examined the interaction of weight and SBP with albuminuria at baseline and with the changes in estimated glomerular filtration rate (eGFR) during the observational period. RESULTS Our results included mean age (54 years old), blood pressure (138/80), eGFR (53 ml/min/1.73 m2), and urine albumin levels (0.2 g/day). SBP was significantly correlated with log-transformed urine albumin levels (r = 0.4, P = 0.01) in patients who were overweight (n = 38) compared with patients who were not overweight (n = 59). Multiple regression analysis revealed that the interaction between being overweight and SBP with respect to albuminuria was significantly correlated with the log-transformed urine albumin level (β = 0.39, P = 0.047) and was independent of age, sex, and potential confounding factors. The interaction between weight and SBP ≥140 mm Hg was significantly associated with a greater decrease in eGFR in the following 3 years. CONCLUSIONS Being overweight may enhance susceptibility to hypertensive glomerular damage and may eventually lead to renal progression in patients with hypertensive nephrosclerosis.

UR - http://www.scopus.com/inward/record.url?scp=85065086895&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85065086895&partnerID=8YFLogxK

U2 - 10.1093/ajh/hpz010

DO - 10.1093/ajh/hpz010

M3 - Article

C2 - 30689693

AN - SCOPUS:85065086895

VL - 32

SP - 486

EP - 491

JO - American Journal of Hypertension

JF - American Journal of Hypertension

SN - 0895-7061

IS - 5

ER -

Research Group of Diabetic Nephropathy and Nephrosclerosis, Ministry of Health, Labour and Welfare of Japan, Japan Agency for Medical Research and Development. Amplified association between blood pressure and albuminuria in overweight patients with biopsy-proven hypertensive nephrosclerosis. American Journal of Hypertension. 2019 Jan 1;32(5):486-491. https://doi.org/10.1093/ajh/hpz010