TY - JOUR
T1 - Amplified association between blood pressure and albuminuria in overweight patients with biopsy-proven hypertensive nephrosclerosis
AU - Research Group of Diabetic Nephropathy and Nephrosclerosis
AU - Ministry of Health, Labour and Welfare of Japan
AU - Japan Agency for Medical Research and Development
AU - Kohagura, Kentaro
AU - Furuichi, Kengo
AU - Kochi, Masako
AU - Shimizu, Miho
AU - Yuzawa, Yukio
AU - Hara, Akinori
AU - Toyama, Tadashi
AU - Kitamura, Hiroshi
AU - Suzuki, Yoshiki
AU - Sato, Hiroshi
AU - Uesugi, Noriko
AU - Ubara, Yoshifumi
AU - Hoshino, Junichi
AU - Hisano, Satoshi
AU - Ueda, Yoshihiko
AU - Nishi, Shinichi
AU - Yokoyama, Hitoshi
AU - Nishino, Tomoya
AU - Ogawa, Daisuke
AU - Mise, Koki
AU - Shibagaki, Yugo
AU - Kimura, Kenjiro
AU - Haneda, Masakazu
AU - Makino, Hirofumi
AU - Matsuo, Seiichi
AU - Wada, Takashi
N1 - Publisher Copyright:
© American Journal of Hypertension, Ltd 2019. All rights reserved.
PY - 2019/4/22
Y1 - 2019/4/22
N2 - BACKGROUND An overweight person is at high risk for hypertensive renal damage. The effect of weight on the association between systolic blood pressure (SBP) and albuminuria remains unknown in patients with histologically diagnosed hypertensive nephrosclerosis. METHODS A total of 97 patients with biopsy-confirmed hypertensive nephrosclerosis were recruited from 13 centers throughout Japan. We examined the relationship between SBP and proteinuria among those who were overweight, which is defined as a body mass index ≥25 kg/m2, and those who were not. We examined the interaction of weight and SBP with albuminuria at baseline and with the changes in estimated glomerular filtration rate (eGFR) during the observational period. RESULTS Our results included mean age (54 years old), blood pressure (138/80), eGFR (53 ml/min/1.73 m2), and urine albumin levels (0.2 g/day). SBP was significantly correlated with log-transformed urine albumin levels (r = 0.4, P = 0.01) in patients who were overweight (n = 38) compared with patients who were not overweight (n = 59). Multiple regression analysis revealed that the interaction between being overweight and SBP with respect to albuminuria was significantly correlated with the log-transformed urine albumin level (β = 0.39, P = 0.047) and was independent of age, sex, and potential confounding factors. The interaction between weight and SBP ≥140 mm Hg was significantly associated with a greater decrease in eGFR in the following 3 years. CONCLUSIONS Being overweight may enhance susceptibility to hypertensive glomerular damage and may eventually lead to renal progression in patients with hypertensive nephrosclerosis.
AB - BACKGROUND An overweight person is at high risk for hypertensive renal damage. The effect of weight on the association between systolic blood pressure (SBP) and albuminuria remains unknown in patients with histologically diagnosed hypertensive nephrosclerosis. METHODS A total of 97 patients with biopsy-confirmed hypertensive nephrosclerosis were recruited from 13 centers throughout Japan. We examined the relationship between SBP and proteinuria among those who were overweight, which is defined as a body mass index ≥25 kg/m2, and those who were not. We examined the interaction of weight and SBP with albuminuria at baseline and with the changes in estimated glomerular filtration rate (eGFR) during the observational period. RESULTS Our results included mean age (54 years old), blood pressure (138/80), eGFR (53 ml/min/1.73 m2), and urine albumin levels (0.2 g/day). SBP was significantly correlated with log-transformed urine albumin levels (r = 0.4, P = 0.01) in patients who were overweight (n = 38) compared with patients who were not overweight (n = 59). Multiple regression analysis revealed that the interaction between being overweight and SBP with respect to albuminuria was significantly correlated with the log-transformed urine albumin level (β = 0.39, P = 0.047) and was independent of age, sex, and potential confounding factors. The interaction between weight and SBP ≥140 mm Hg was significantly associated with a greater decrease in eGFR in the following 3 years. CONCLUSIONS Being overweight may enhance susceptibility to hypertensive glomerular damage and may eventually lead to renal progression in patients with hypertensive nephrosclerosis.
KW - Blood pressure
KW - Hypertension
KW - Hypertensive renal damage
KW - Nephrosclerosis
KW - Overweight
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U2 - 10.1093/ajh/hpz010
DO - 10.1093/ajh/hpz010
M3 - Article
C2 - 30689693
AN - SCOPUS:85065086895
SN - 0895-7061
VL - 32
SP - 486
EP - 491
JO - American Journal of Hypertension
JF - American Journal of Hypertension
IS - 5
ER -