TY - JOUR
T1 - Amplitude decrease of photopic ERG b-wave at higher stimulus intensities in humans
AU - Kondo, Mineo
AU - Piao, Chang Hua
AU - Tanikawa, Atsuhiro
AU - Horiguchi, Masayuki
AU - Terasaki, Hiroko
AU - Miyake, Yozo
N1 - Funding Information:
The authors thank Masao Yoshikawa, Hideaki Funada, and Eiichiro Nagasaka of the Tomey Company (Nagoya) for their excellent technical help. This research was supported by Grant-in-Aid No. 08457462 from the Ministry of Education, Science, Sports and Culture, Japan.
PY - 2000/1
Y1 - 2000/1
N2 - Purpose: The b-wave of the human photopic electroretinogram (ERG) elicited by a short-flash increases in amplitude with increasing stimulus intensities at lower stimulus levels, but then decreases at higher stimulus intensities. The purpose of the present study was to explore this phenomenon in more detail, using short- and long-flash stimuli. Methods: The intensity-response functions of the b-wave elicited by short- and long-flashes were compared from threshold to higher stimulus intensities in 5 normal subjects. Short- and long-flash ERGs were elicited under rod-saturating background levels using white light-emitting diodes built into a contact lens electrode. Results: Whereas the amplitude of the short-flash b-wave decreased at higher intensities, the amplitude of the long-flash ERG b-wave did not decrease but plateaued. The long-flash ERG d-wave or OFF-response decreased at higher stimulus levels as did the short-flash elicited b-wave.Conclusions: Because it is widely accepted that the b-wave and the OFF-response d-wave interact to produce a single positive response, our results suggest that the decrease in the b-wave amplitude at high stimulus intensity is caused by the decrease of the d-wave at the higher stimulus intensities. Copyright (C) 2000 Japanese Ophthalmological Society.
AB - Purpose: The b-wave of the human photopic electroretinogram (ERG) elicited by a short-flash increases in amplitude with increasing stimulus intensities at lower stimulus levels, but then decreases at higher stimulus intensities. The purpose of the present study was to explore this phenomenon in more detail, using short- and long-flash stimuli. Methods: The intensity-response functions of the b-wave elicited by short- and long-flashes were compared from threshold to higher stimulus intensities in 5 normal subjects. Short- and long-flash ERGs were elicited under rod-saturating background levels using white light-emitting diodes built into a contact lens electrode. Results: Whereas the amplitude of the short-flash b-wave decreased at higher intensities, the amplitude of the long-flash ERG b-wave did not decrease but plateaued. The long-flash ERG d-wave or OFF-response decreased at higher stimulus levels as did the short-flash elicited b-wave.Conclusions: Because it is widely accepted that the b-wave and the OFF-response d-wave interact to produce a single positive response, our results suggest that the decrease in the b-wave amplitude at high stimulus intensity is caused by the decrease of the d-wave at the higher stimulus intensities. Copyright (C) 2000 Japanese Ophthalmological Society.
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U2 - 10.1016/S0021-5155(99)00172-0
DO - 10.1016/S0021-5155(99)00172-0
M3 - Article
C2 - 10698021
AN - SCOPUS:0033970961
SN - 0021-5155
VL - 44
SP - 20
EP - 28
JO - Japanese Journal of Ophthalmology
JF - Japanese Journal of Ophthalmology
IS - 1
ER -