Amyloid β-peptide induces cholinergic dysfunction and cognitive deficits: A minireview

Manh Hung Tran, Kiyofumi Yamada, Toshitaka Nabeshima

Research output: Contribution to journalReview article

52 Citations (Scopus)

Abstract

Amyloid β-peptide (Aβ) plays a critical role in the development of Alzheimer's disease (AD). Much progress has been made in understanding this age-related neurodegenerative disorder, thus an insight into the cellular actions of Aβ and resulting functional consequences may contribute to preventive and therapeutic approaches for AD. In this review, recent evidence of Aβ-induced brain dysfunction, particularly of cholinergic impairment and memory deficits is summarized. Moreover, proposed mechanisms for Aβ-induced neurotoxicity such as oxidative stress, ion-channel formation, and Aβ-receptor interaction are discussed.

Original languageEnglish
Pages (from-to)1271-1283
Number of pages13
JournalPeptides
Volume23
Issue number7
DOIs
Publication statusPublished - 01-01-2002

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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