Amyloid βprotein precursors with kunitz‐type inhibitor domains and acetyl‐cholinesterase in cerebrospinal fluid from patients with dementia of the Alzheimer type

K. Urakami, K. Takahashi, H. Saito, A. Okada, S. Nakamura, S. Tanaka, Nobuya Kitaguchi, Y. Tokushima, S. Yamamoto

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We used the ELISA to measure the concentration of amyloid protein precursor with Kunitz type trypsin inhibitor domains (APPI) in CSF of dementia of the Alzheimer type (DAT) and examined the correlation of APPI with acetylcholinesterase (AChE) and somatostatin (SRIF). We found the APPI concentration in CSF of DAT to be significantly elevated compared with that of multi‐infarct dementia and controls. We could significantly correlate APPI with AChE, but not correlate APPI with SRIF. The present results suggest that measurement of CSF APPI levels may be useful for diagnosis of DAT and the change of APPI may closely be associated with abnormality of acetylcholine system in DAT that has been reported.

Original languageEnglish
Pages (from-to)343-346
Number of pages4
JournalActa Neurologica Scandinavica
Volume85
Issue number5
DOIs
Publication statusPublished - 01-01-1992

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Amyloid beta-Protein Precursor
Cholinesterase Inhibitors
Cerebrospinal Fluid
Alzheimer Disease
Acetylcholinesterase
Multi-Infarct Dementia
Trypsin Inhibitors
Somatostatin
Acetylcholine
Enzyme-Linked Immunosorbent Assay

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Urakami, K. ; Takahashi, K. ; Saito, H. ; Okada, A. ; Nakamura, S. ; Tanaka, S. ; Kitaguchi, Nobuya ; Tokushima, Y. ; Yamamoto, S. / Amyloid βprotein precursors with kunitz‐type inhibitor domains and acetyl‐cholinesterase in cerebrospinal fluid from patients with dementia of the Alzheimer type. In: Acta Neurologica Scandinavica. 1992 ; Vol. 85, No. 5. pp. 343-346.
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Amyloid βprotein precursors with kunitz‐type inhibitor domains and acetyl‐cholinesterase in cerebrospinal fluid from patients with dementia of the Alzheimer type. / Urakami, K.; Takahashi, K.; Saito, H.; Okada, A.; Nakamura, S.; Tanaka, S.; Kitaguchi, Nobuya; Tokushima, Y.; Yamamoto, S.

In: Acta Neurologica Scandinavica, Vol. 85, No. 5, 01.01.1992, p. 343-346.

Research output: Contribution to journalArticle

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AU - Urakami, K.

AU - Takahashi, K.

AU - Saito, H.

AU - Okada, A.

AU - Nakamura, S.

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AU - Kitaguchi, Nobuya

AU - Tokushima, Y.

AU - Yamamoto, S.

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AB - We used the ELISA to measure the concentration of amyloid protein precursor with Kunitz type trypsin inhibitor domains (APPI) in CSF of dementia of the Alzheimer type (DAT) and examined the correlation of APPI with acetylcholinesterase (AChE) and somatostatin (SRIF). We found the APPI concentration in CSF of DAT to be significantly elevated compared with that of multi‐infarct dementia and controls. We could significantly correlate APPI with AChE, but not correlate APPI with SRIF. The present results suggest that measurement of CSF APPI levels may be useful for diagnosis of DAT and the change of APPI may closely be associated with abnormality of acetylcholine system in DAT that has been reported.

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