Amyloid pathology and protein kinase C (PKC): Possible therapeutics effects of PKC activators

Ana Olariu, Kiyofumi Yamada, Toshitaka Nabeshima

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

Amyloid β-protein (Aβ) is one of the most studied peptides in human neurodegenerative disorders. Although much has been learned about the biochemistry of this peptide, fundamental questions such as when and how the Aβ becomes pathologic remain unanswered. In this article we review the recent findings on the biology and pathology of Aβ and the role protein kinase C (PKC) plays in these processes. The potential neuroprotective role of PKC and the possible therapeutic effects of PKC activators in Alzheimer's disease (AD) will be discussed. Briefly, comments will be also addressed on the role of PKC in cell death and neurogenesis in AD.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalJournal of Pharmacological Sciences
Volume97
Issue number1
DOIs
Publication statusPublished - 01-01-2005

Fingerprint

Amyloidogenic Proteins
Therapeutic Uses
Protein Kinase C
Pathology
Alzheimer Disease
Serum Amyloid A Protein
Peptides
Neurogenesis
Neurodegenerative Diseases
Biochemistry
Cell Death

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

Cite this

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Amyloid pathology and protein kinase C (PKC) : Possible therapeutics effects of PKC activators. / Olariu, Ana; Yamada, Kiyofumi; Nabeshima, Toshitaka.

In: Journal of Pharmacological Sciences, Vol. 97, No. 1, 01.01.2005, p. 1-5.

Research output: Contribution to journalReview article

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