An association between central aortic pressure and subclinical organ damage of the heart among a general Japanese cohort: Circulatory Risk in Communities Study (CIRCS)

Renzhe Cui, Yuanying Li, Gero Krisztina, Kazumasa Yamagishi, Mitsumasa Umesawa, Hironori Imano, Tetsuya Ohira, Masahiko Kiyama, Takeo Okada, Akihiko Kitamura, Shinichi Hitsumoto, Takeshi Tanigawa, Hiroyasu Iso

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Abstract

Background: This study aimed to investigate associations between central aortic pressure (CAP) and subclinical organ damage of the heart amongst the general population. Methods: We conducted a cross-sectional study in a community-based population, consisting of 3002 men and women aged between 40 and 79 years. The CAP was measured using the HEM-9000AI device, an automated tonometer. Electrocardiograms (ECG) were read according to the Minnesota Code. Subclinical organ damage in the heart was defined as measurable left high amplitude R waves (LHAR), major and minor ST-T abnormalities, and left ventricular hypertrophy (LVH). Results: Age- and sex-adjusted prevalence of LHAR, major and minor ST-T abnormalities, and LVH was higher for subjects in the highest tertile of CAP levels than those in the lowest tertile. After further adjustments for other cardiovascular risk factors, these associations did not change substantially. The multivariable odds ratios (ORs) (95% CI) of LHAR, major and minor ST-T abnormalities, and LVH for the highest tertile of CAP levels compared to the lowest tertile were 2.7(1.9-3.9), 1.8(1.1-2.9), 1.7(1.3-2.3) and 3.2(1.3-8.1), respectively. The positive associations with LHAR and minor ST-T abnormalities were observed primarily among non-hypertensive subjects. The respective corresponding ORs were 2.8(1.7-4.6) and 1.7(1.2-2.4) for non-hypertensive subjects, and 1.7(0.9-3.3) and 1.1(0.7-1.8) for hypertensive subjects. Conclusion: CAP levels were associated with subclinical organ damage of the heart independent of cardiovascular risk factors, and these associations were primarily seen in non-hypertensive subjects.

Original languageEnglish
Pages (from-to)94-98
Number of pages5
JournalAtherosclerosis
Volume232
Issue number1
DOIs
Publication statusPublished - 01-01-2014

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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    Cui, R., Li, Y., Krisztina, G., Yamagishi, K., Umesawa, M., Imano, H., Ohira, T., Kiyama, M., Okada, T., Kitamura, A., Hitsumoto, S., Tanigawa, T., & Iso, H. (2014). An association between central aortic pressure and subclinical organ damage of the heart among a general Japanese cohort: Circulatory Risk in Communities Study (CIRCS). Atherosclerosis, 232(1), 94-98. https://doi.org/10.1016/j.atherosclerosis.2013.10.012