An association between serotonin receptor 3B gene (HTR3B) and treatment-resistant schizophrenia (TRS) in a Japanese population.

Xiaofei Ji, Nagahide Takahashi, Aleksic Branko, Ryoko Ishihara, Taku Nagai, Akihiro Mouri, Shinichi Saito, Nobuhisa Maeno, Toshiya Inada, Norio Ozaki

Research output: Contribution to journalArticle

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Abstract

Genetic factors are thought to be involved in the development of treatment-resistant schizophrenia (TRS). Since several antipsychotic drugs inhibit the release of neurotransmitters via the serotonin receptors 3 (5-HT3), a dysfunction of this kind of receptor might be associated with the development of TRS. Thus, single-marker and haplotype analyses of the tag-single nucleotide polymorphisms (SNPs) of the 5-HT3B subunit gene (HTR3B) were performed in TRS (n = 101) and non-TRS (n = 244) patients. The deletion allele at the 3 bp-insertion/deletion polymorphism site (-100_-102delAAG) located in the putative HTR3B promoter region is significantly more frequent in the TRS group than the insertion allele by a single-marker comparison (p = 0.031). In addition, luciferase promoter assays showed that the deletion allele exhibited significantly higher transcriptional activity than the insertion allele in COS7 cells (p < 0.05). These results suggest that HTR3B is involved in the development of TRS in the Japanese population.

Original languageEnglish
Pages (from-to)11-17
Number of pages7
JournalNagoya Journal of Medical Science
Volume70
Issue number1-2
Publication statusPublished - 01-01-2008

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Serotonin Receptors
Schizophrenia
Alleles
Population
Genes
Therapeutics
Receptors, Serotonin, 5-HT3
Luciferases
Genetic Promoter Regions
Haplotypes
Antipsychotic Agents
Single Nucleotide Polymorphism
Neurotransmitter Agents

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Ji, Xiaofei ; Takahashi, Nagahide ; Branko, Aleksic ; Ishihara, Ryoko ; Nagai, Taku ; Mouri, Akihiro ; Saito, Shinichi ; Maeno, Nobuhisa ; Inada, Toshiya ; Ozaki, Norio. / An association between serotonin receptor 3B gene (HTR3B) and treatment-resistant schizophrenia (TRS) in a Japanese population. In: Nagoya Journal of Medical Science. 2008 ; Vol. 70, No. 1-2. pp. 11-17.
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abstract = "Genetic factors are thought to be involved in the development of treatment-resistant schizophrenia (TRS). Since several antipsychotic drugs inhibit the release of neurotransmitters via the serotonin receptors 3 (5-HT3), a dysfunction of this kind of receptor might be associated with the development of TRS. Thus, single-marker and haplotype analyses of the tag-single nucleotide polymorphisms (SNPs) of the 5-HT3B subunit gene (HTR3B) were performed in TRS (n = 101) and non-TRS (n = 244) patients. The deletion allele at the 3 bp-insertion/deletion polymorphism site (-100_-102delAAG) located in the putative HTR3B promoter region is significantly more frequent in the TRS group than the insertion allele by a single-marker comparison (p = 0.031). In addition, luciferase promoter assays showed that the deletion allele exhibited significantly higher transcriptional activity than the insertion allele in COS7 cells (p < 0.05). These results suggest that HTR3B is involved in the development of TRS in the Japanese population.",
author = "Xiaofei Ji and Nagahide Takahashi and Aleksic Branko and Ryoko Ishihara and Taku Nagai and Akihiro Mouri and Shinichi Saito and Nobuhisa Maeno and Toshiya Inada and Norio Ozaki",
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Ji, X, Takahashi, N, Branko, A, Ishihara, R, Nagai, T, Mouri, A, Saito, S, Maeno, N, Inada, T & Ozaki, N 2008, 'An association between serotonin receptor 3B gene (HTR3B) and treatment-resistant schizophrenia (TRS) in a Japanese population.', Nagoya Journal of Medical Science, vol. 70, no. 1-2, pp. 11-17.

An association between serotonin receptor 3B gene (HTR3B) and treatment-resistant schizophrenia (TRS) in a Japanese population. / Ji, Xiaofei; Takahashi, Nagahide; Branko, Aleksic; Ishihara, Ryoko; Nagai, Taku; Mouri, Akihiro; Saito, Shinichi; Maeno, Nobuhisa; Inada, Toshiya; Ozaki, Norio.

In: Nagoya Journal of Medical Science, Vol. 70, No. 1-2, 01.01.2008, p. 11-17.

Research output: Contribution to journalArticle

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AU - Ji, Xiaofei

AU - Takahashi, Nagahide

AU - Branko, Aleksic

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AU - Nagai, Taku

AU - Mouri, Akihiro

AU - Saito, Shinichi

AU - Maeno, Nobuhisa

AU - Inada, Toshiya

AU - Ozaki, Norio

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N2 - Genetic factors are thought to be involved in the development of treatment-resistant schizophrenia (TRS). Since several antipsychotic drugs inhibit the release of neurotransmitters via the serotonin receptors 3 (5-HT3), a dysfunction of this kind of receptor might be associated with the development of TRS. Thus, single-marker and haplotype analyses of the tag-single nucleotide polymorphisms (SNPs) of the 5-HT3B subunit gene (HTR3B) were performed in TRS (n = 101) and non-TRS (n = 244) patients. The deletion allele at the 3 bp-insertion/deletion polymorphism site (-100_-102delAAG) located in the putative HTR3B promoter region is significantly more frequent in the TRS group than the insertion allele by a single-marker comparison (p = 0.031). In addition, luciferase promoter assays showed that the deletion allele exhibited significantly higher transcriptional activity than the insertion allele in COS7 cells (p < 0.05). These results suggest that HTR3B is involved in the development of TRS in the Japanese population.

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