An association study of monoamine oxidase A (MAOA) gene polymorphism in methamphetamine psychosis

Kazuhiko Nakamura, Yoshimoto Sekine, Noriyoshi Takei, Yasuhide Iwata, Katsuaki Suzuki, Ayyappan Anitha, Toshiya Inada, Mutsuo Harano, Tokutaro Komiyama, Mitsuhiko Yamada, Nakao Iwata, Masaomi Iyo, Ichiro Sora, Norio Ozaki, Hiroshi Ujike, Norio Mori

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Methamphetamine continues to be the most widely abused drug in Japan. Chronic methamphetamine users show psychiatric signs, including methamphetamine psychosis. Monoamine oxidase A (MAOA) is one of the major enzymes responsible for the degradation of neurotransmitters. Abnormalities in MAO levels have been related to a wide range of psychiatric disorders. We examined whether or not the MAOA-u variable-number tandem repeat (VNTR) has a functional polymorphism in methamphetamine psychosis and whether or not such a polymorphism is related to the prolongation of psychosis. As expected, there was a significant difference in the MAOA-u VNTR between males with persistent versus transient methamphetamine psychosis (p = 0.018, odds ratio (OR) = 2.76, 95% CI: 1.18-6.46). Our results suggest that the high-activity allele class of MAOA-u VNTR in males may be involved in susceptibility to a persistent course of methamphetamine psychosis. We found no differences among females. The sample size of females with methamphetamine psychosis was too small to have significant analysis.

Original languageEnglish
Pages (from-to)120-123
Number of pages4
JournalNeuroscience Letters
Volume455
Issue number2
DOIs
Publication statusPublished - 15-05-2009

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Methamphetamine
Monoamine Oxidase
Psychotic Disorders
Minisatellite Repeats
Genes
Psychiatry
Sample Size
Neurotransmitter Agents
Japan
Alleles
Odds Ratio
Enzymes
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Nakamura, K., Sekine, Y., Takei, N., Iwata, Y., Suzuki, K., Anitha, A., ... Mori, N. (2009). An association study of monoamine oxidase A (MAOA) gene polymorphism in methamphetamine psychosis. Neuroscience Letters, 455(2), 120-123. https://doi.org/10.1016/j.neulet.2009.02.048
Nakamura, Kazuhiko ; Sekine, Yoshimoto ; Takei, Noriyoshi ; Iwata, Yasuhide ; Suzuki, Katsuaki ; Anitha, Ayyappan ; Inada, Toshiya ; Harano, Mutsuo ; Komiyama, Tokutaro ; Yamada, Mitsuhiko ; Iwata, Nakao ; Iyo, Masaomi ; Sora, Ichiro ; Ozaki, Norio ; Ujike, Hiroshi ; Mori, Norio. / An association study of monoamine oxidase A (MAOA) gene polymorphism in methamphetamine psychosis. In: Neuroscience Letters. 2009 ; Vol. 455, No. 2. pp. 120-123.
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abstract = "Methamphetamine continues to be the most widely abused drug in Japan. Chronic methamphetamine users show psychiatric signs, including methamphetamine psychosis. Monoamine oxidase A (MAOA) is one of the major enzymes responsible for the degradation of neurotransmitters. Abnormalities in MAO levels have been related to a wide range of psychiatric disorders. We examined whether or not the MAOA-u variable-number tandem repeat (VNTR) has a functional polymorphism in methamphetamine psychosis and whether or not such a polymorphism is related to the prolongation of psychosis. As expected, there was a significant difference in the MAOA-u VNTR between males with persistent versus transient methamphetamine psychosis (p = 0.018, odds ratio (OR) = 2.76, 95{\%} CI: 1.18-6.46). Our results suggest that the high-activity allele class of MAOA-u VNTR in males may be involved in susceptibility to a persistent course of methamphetamine psychosis. We found no differences among females. The sample size of females with methamphetamine psychosis was too small to have significant analysis.",
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Nakamura, K, Sekine, Y, Takei, N, Iwata, Y, Suzuki, K, Anitha, A, Inada, T, Harano, M, Komiyama, T, Yamada, M, Iwata, N, Iyo, M, Sora, I, Ozaki, N, Ujike, H & Mori, N 2009, 'An association study of monoamine oxidase A (MAOA) gene polymorphism in methamphetamine psychosis', Neuroscience Letters, vol. 455, no. 2, pp. 120-123. https://doi.org/10.1016/j.neulet.2009.02.048

An association study of monoamine oxidase A (MAOA) gene polymorphism in methamphetamine psychosis. / Nakamura, Kazuhiko; Sekine, Yoshimoto; Takei, Noriyoshi; Iwata, Yasuhide; Suzuki, Katsuaki; Anitha, Ayyappan; Inada, Toshiya; Harano, Mutsuo; Komiyama, Tokutaro; Yamada, Mitsuhiko; Iwata, Nakao; Iyo, Masaomi; Sora, Ichiro; Ozaki, Norio; Ujike, Hiroshi; Mori, Norio.

In: Neuroscience Letters, Vol. 455, No. 2, 15.05.2009, p. 120-123.

Research output: Contribution to journalArticle

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T1 - An association study of monoamine oxidase A (MAOA) gene polymorphism in methamphetamine psychosis

AU - Nakamura, Kazuhiko

AU - Sekine, Yoshimoto

AU - Takei, Noriyoshi

AU - Iwata, Yasuhide

AU - Suzuki, Katsuaki

AU - Anitha, Ayyappan

AU - Inada, Toshiya

AU - Harano, Mutsuo

AU - Komiyama, Tokutaro

AU - Yamada, Mitsuhiko

AU - Iwata, Nakao

AU - Iyo, Masaomi

AU - Sora, Ichiro

AU - Ozaki, Norio

AU - Ujike, Hiroshi

AU - Mori, Norio

PY - 2009/5/15

Y1 - 2009/5/15

N2 - Methamphetamine continues to be the most widely abused drug in Japan. Chronic methamphetamine users show psychiatric signs, including methamphetamine psychosis. Monoamine oxidase A (MAOA) is one of the major enzymes responsible for the degradation of neurotransmitters. Abnormalities in MAO levels have been related to a wide range of psychiatric disorders. We examined whether or not the MAOA-u variable-number tandem repeat (VNTR) has a functional polymorphism in methamphetamine psychosis and whether or not such a polymorphism is related to the prolongation of psychosis. As expected, there was a significant difference in the MAOA-u VNTR between males with persistent versus transient methamphetamine psychosis (p = 0.018, odds ratio (OR) = 2.76, 95% CI: 1.18-6.46). Our results suggest that the high-activity allele class of MAOA-u VNTR in males may be involved in susceptibility to a persistent course of methamphetamine psychosis. We found no differences among females. The sample size of females with methamphetamine psychosis was too small to have significant analysis.

AB - Methamphetamine continues to be the most widely abused drug in Japan. Chronic methamphetamine users show psychiatric signs, including methamphetamine psychosis. Monoamine oxidase A (MAOA) is one of the major enzymes responsible for the degradation of neurotransmitters. Abnormalities in MAO levels have been related to a wide range of psychiatric disorders. We examined whether or not the MAOA-u variable-number tandem repeat (VNTR) has a functional polymorphism in methamphetamine psychosis and whether or not such a polymorphism is related to the prolongation of psychosis. As expected, there was a significant difference in the MAOA-u VNTR between males with persistent versus transient methamphetamine psychosis (p = 0.018, odds ratio (OR) = 2.76, 95% CI: 1.18-6.46). Our results suggest that the high-activity allele class of MAOA-u VNTR in males may be involved in susceptibility to a persistent course of methamphetamine psychosis. We found no differences among females. The sample size of females with methamphetamine psychosis was too small to have significant analysis.

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