An epilepsy-associated glioneuronal tumor with mixed morphology harboring FGFR1 mutation

Seiji Yamada, Sumihito Nobusawa, Tatsuya Yamazaki, Takao Teranishi, Sadayoshi Watanabe, Kazuhiro Murayama, Shigeo Ohba, Asako Okabe, Kohei Sakurai, Makoto Urano, Tetsuya Tsukamoto, Hideaki Yokoo, Yuichi Hirose, Masato Abe

Research output: Contribution to journalArticle

Abstract

Glioneuronal tumor (GNT) is a rare central nervous system neoplasm composed of glial and neuronal components. Making the specific diagnosis of GNT can be challenging due to histopathological and genetical similarities among some GNTs and low-grade gliomas. We report a case of GNT with rosette-forming glioneuronal tumor, dysembryoplastic neuroepithelial tumor, and pilocytic astrocytoma-like morphology harboring FGFR1 mutation. A 16-year-old female presented with absence seizures. Magnetic resonance imaging revealed a right temporal lobe mass with multinodular enhancement by gadolinium administration. The tumor was mostly composed of oligodendrocyte-like cells (OLCs) with variable perinuclear haloes. Abundant Rosenthal fibers and eosinophilic granular bodies were identified. Neither mitotic figures nor areas of necrosis were seen. Focal neurocytic rosette features, involving ring-like arrays of OLCs around eosinophilic cores, were observed. Direct sequencing showed a missense mutation in FGFR1 K656E, whereas FGFR1 N546K, PIK3CA, and BRAF V600E were intact. KIAA1549-BRAF fusion was not detected by fluorescence in situ hybridization analysis.

Original languageEnglish
Pages (from-to)372-377
Number of pages6
JournalPathology International
Volume69
Issue number6
DOIs
Publication statusPublished - 01-01-2019

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Epilepsy
Mutation
Oligodendroglia
Neoplasms
Neuroepithelial Neoplasms
Absence Epilepsy
Central Nervous System Neoplasms
Astrocytoma
Gadolinium
Missense Mutation
Temporal Lobe
Fluorescence In Situ Hybridization
Glioma
Neuroglia
Necrosis
Magnetic Resonance Imaging

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Yamada, S., Nobusawa, S., Yamazaki, T., Teranishi, T., Watanabe, S., Murayama, K., ... Abe, M. (2019). An epilepsy-associated glioneuronal tumor with mixed morphology harboring FGFR1 mutation. Pathology International, 69(6), 372-377. https://doi.org/10.1111/pin.12799
Yamada, Seiji ; Nobusawa, Sumihito ; Yamazaki, Tatsuya ; Teranishi, Takao ; Watanabe, Sadayoshi ; Murayama, Kazuhiro ; Ohba, Shigeo ; Okabe, Asako ; Sakurai, Kohei ; Urano, Makoto ; Tsukamoto, Tetsuya ; Yokoo, Hideaki ; Hirose, Yuichi ; Abe, Masato. / An epilepsy-associated glioneuronal tumor with mixed morphology harboring FGFR1 mutation. In: Pathology International. 2019 ; Vol. 69, No. 6. pp. 372-377.
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Yamada, S, Nobusawa, S, Yamazaki, T, Teranishi, T, Watanabe, S, Murayama, K, Ohba, S, Okabe, A, Sakurai, K, Urano, M, Tsukamoto, T, Yokoo, H, Hirose, Y & Abe, M 2019, 'An epilepsy-associated glioneuronal tumor with mixed morphology harboring FGFR1 mutation', Pathology International, vol. 69, no. 6, pp. 372-377. https://doi.org/10.1111/pin.12799

An epilepsy-associated glioneuronal tumor with mixed morphology harboring FGFR1 mutation. / Yamada, Seiji; Nobusawa, Sumihito; Yamazaki, Tatsuya; Teranishi, Takao; Watanabe, Sadayoshi; Murayama, Kazuhiro; Ohba, Shigeo; Okabe, Asako; Sakurai, Kohei; Urano, Makoto; Tsukamoto, Tetsuya; Yokoo, Hideaki; Hirose, Yuichi; Abe, Masato.

In: Pathology International, Vol. 69, No. 6, 01.01.2019, p. 372-377.

Research output: Contribution to journalArticle

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AU - Yamada, Seiji

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AU - Yamazaki, Tatsuya

AU - Teranishi, Takao

AU - Watanabe, Sadayoshi

AU - Murayama, Kazuhiro

AU - Ohba, Shigeo

AU - Okabe, Asako

AU - Sakurai, Kohei

AU - Urano, Makoto

AU - Tsukamoto, Tetsuya

AU - Yokoo, Hideaki

AU - Hirose, Yuichi

AU - Abe, Masato

PY - 2019/1/1

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N2 - Glioneuronal tumor (GNT) is a rare central nervous system neoplasm composed of glial and neuronal components. Making the specific diagnosis of GNT can be challenging due to histopathological and genetical similarities among some GNTs and low-grade gliomas. We report a case of GNT with rosette-forming glioneuronal tumor, dysembryoplastic neuroepithelial tumor, and pilocytic astrocytoma-like morphology harboring FGFR1 mutation. A 16-year-old female presented with absence seizures. Magnetic resonance imaging revealed a right temporal lobe mass with multinodular enhancement by gadolinium administration. The tumor was mostly composed of oligodendrocyte-like cells (OLCs) with variable perinuclear haloes. Abundant Rosenthal fibers and eosinophilic granular bodies were identified. Neither mitotic figures nor areas of necrosis were seen. Focal neurocytic rosette features, involving ring-like arrays of OLCs around eosinophilic cores, were observed. Direct sequencing showed a missense mutation in FGFR1 K656E, whereas FGFR1 N546K, PIK3CA, and BRAF V600E were intact. KIAA1549-BRAF fusion was not detected by fluorescence in situ hybridization analysis.

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Yamada S, Nobusawa S, Yamazaki T, Teranishi T, Watanabe S, Murayama K et al. An epilepsy-associated glioneuronal tumor with mixed morphology harboring FGFR1 mutation. Pathology International. 2019 Jan 1;69(6):372-377. https://doi.org/10.1111/pin.12799