An evaluation of association between a novel hippocampal biology related SNP (rs7294919) and schizophrenia

Jiewei Liu, Shusuke Numata, Masashi Ikeda, Yuichiro Watanabe, Xue Bin Zheng, Xiongjian Luo, Makoto Kinoshita, Ayako Nunokawa, Toshiyuki Someya, Tetsuro Ohmori, Jin Xin Bei, Siow Ann Chong, Jimmy Lee, Zhiqiang Li, Jianjun Liu, Nakao Iwata, Yongyong Shi, Ming Li, Bing Su

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Abstract

Recent genetic analyses have implicated several candidate susceptibility variants for schizophrenia. The single nucleotide polymorphism (SNP) rs7294919 is likely a schizophrenia-susceptibility variant according to its significant association with hippocampal volume, hippocampus function, and cognitive performance as well as the nominal association with schizophrenia. However, all previous analyses were conducted only in Europeans, and whether rs7294919 is associated with schizophrenia in other populations are yet to be tested. Here, we conducted a case-control analysis of rs7294919 with schizophrenia in six independent Chinese (N = 3) and Japanese (N = 3) samples, including a total of 7,352 cases and 10,824 controls. The results of our association analysis were not able to confirm the association of rs7294919 with schizophrenia (p = 0.51 in total samples, odds ratio = 1.02 for allele[C]). The absence of rs7294919's association in Chinese and Japanese suggest a potential genetic heterogeneity in the susceptibility of schizophrenia on this locus and also demonstrate the difficulties in replicating associations of schizophrenia across different ethnic populations.

Original languageEnglish
Article numbere80696
JournalPloS one
Volume8
Issue number11
DOIs
Publication statusPublished - 22-11-2013

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All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Liu, J., Numata, S., Ikeda, M., Watanabe, Y., Zheng, X. B., Luo, X., Kinoshita, M., Nunokawa, A., Someya, T., Ohmori, T., Bei, J. X., Chong, S. A., Lee, J., Li, Z., Liu, J., Iwata, N., Shi, Y., Li, M., & Su, B. (2013). An evaluation of association between a novel hippocampal biology related SNP (rs7294919) and schizophrenia. PloS one, 8(11), [e80696]. https://doi.org/10.1371/journal.pone.0080696