An evaluation of association between a novel hippocampal biology related SNP (rs7294919) and schizophrenia

Jiewei Liu, Shusuke Numata, Masashi Ikeda, Yuichiro Watanabe, Xue Bin Zheng, Xiongjian Luo, Makoto Kinoshita, Ayako Nunokawa, Toshiyuki Someya, Tetsuro Ohmori, Jin Xin Bei, Siow Ann Chong, Jimmy Lee, Zhiqiang Li, Jianjun Liu, Nakao Iwata, Yongyong Shi, Ming Li, Bing Su

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Abstract

Recent genetic analyses have implicated several candidate susceptibility variants for schizophrenia. The single nucleotide polymorphism (SNP) rs7294919 is likely a schizophrenia-susceptibility variant according to its significant association with hippocampal volume, hippocampus function, and cognitive performance as well as the nominal association with schizophrenia. However, all previous analyses were conducted only in Europeans, and whether rs7294919 is associated with schizophrenia in other populations are yet to be tested. Here, we conducted a case-control analysis of rs7294919 with schizophrenia in six independent Chinese (N = 3) and Japanese (N = 3) samples, including a total of 7,352 cases and 10,824 controls. The results of our association analysis were not able to confirm the association of rs7294919 with schizophrenia (p = 0.51 in total samples, odds ratio = 1.02 for allele[C]). The absence of rs7294919's association in Chinese and Japanese suggest a potential genetic heterogeneity in the susceptibility of schizophrenia on this locus and also demonstrate the difficulties in replicating associations of schizophrenia across different ethnic populations.

Original languageEnglish
Article numbere80696
JournalPLoS One
Volume8
Issue number11
DOIs
Publication statusPublished - 22-11-2013

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Polymorphism
single nucleotide polymorphism
Single Nucleotide Polymorphism
Schizophrenia
Nucleotides
Biological Sciences
Genetic Heterogeneity
schizophrenia
hippocampus
cognition
odds ratio
Cognition
Population
Hippocampus
Alleles
Odds Ratio
alleles
sampling
loci

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Liu, Jiewei ; Numata, Shusuke ; Ikeda, Masashi ; Watanabe, Yuichiro ; Zheng, Xue Bin ; Luo, Xiongjian ; Kinoshita, Makoto ; Nunokawa, Ayako ; Someya, Toshiyuki ; Ohmori, Tetsuro ; Bei, Jin Xin ; Chong, Siow Ann ; Lee, Jimmy ; Li, Zhiqiang ; Liu, Jianjun ; Iwata, Nakao ; Shi, Yongyong ; Li, Ming ; Su, Bing. / An evaluation of association between a novel hippocampal biology related SNP (rs7294919) and schizophrenia. In: PLoS One. 2013 ; Vol. 8, No. 11.
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abstract = "Recent genetic analyses have implicated several candidate susceptibility variants for schizophrenia. The single nucleotide polymorphism (SNP) rs7294919 is likely a schizophrenia-susceptibility variant according to its significant association with hippocampal volume, hippocampus function, and cognitive performance as well as the nominal association with schizophrenia. However, all previous analyses were conducted only in Europeans, and whether rs7294919 is associated with schizophrenia in other populations are yet to be tested. Here, we conducted a case-control analysis of rs7294919 with schizophrenia in six independent Chinese (N = 3) and Japanese (N = 3) samples, including a total of 7,352 cases and 10,824 controls. The results of our association analysis were not able to confirm the association of rs7294919 with schizophrenia (p = 0.51 in total samples, odds ratio = 1.02 for allele[C]). The absence of rs7294919's association in Chinese and Japanese suggest a potential genetic heterogeneity in the susceptibility of schizophrenia on this locus and also demonstrate the difficulties in replicating associations of schizophrenia across different ethnic populations.",
author = "Jiewei Liu and Shusuke Numata and Masashi Ikeda and Yuichiro Watanabe and Zheng, {Xue Bin} and Xiongjian Luo and Makoto Kinoshita and Ayako Nunokawa and Toshiyuki Someya and Tetsuro Ohmori and Bei, {Jin Xin} and Chong, {Siow Ann} and Jimmy Lee and Zhiqiang Li and Jianjun Liu and Nakao Iwata and Yongyong Shi and Ming Li and Bing Su",
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Liu, J, Numata, S, Ikeda, M, Watanabe, Y, Zheng, XB, Luo, X, Kinoshita, M, Nunokawa, A, Someya, T, Ohmori, T, Bei, JX, Chong, SA, Lee, J, Li, Z, Liu, J, Iwata, N, Shi, Y, Li, M & Su, B 2013, 'An evaluation of association between a novel hippocampal biology related SNP (rs7294919) and schizophrenia', PLoS One, vol. 8, no. 11, e80696. https://doi.org/10.1371/journal.pone.0080696

An evaluation of association between a novel hippocampal biology related SNP (rs7294919) and schizophrenia. / Liu, Jiewei; Numata, Shusuke; Ikeda, Masashi; Watanabe, Yuichiro; Zheng, Xue Bin; Luo, Xiongjian; Kinoshita, Makoto; Nunokawa, Ayako; Someya, Toshiyuki; Ohmori, Tetsuro; Bei, Jin Xin; Chong, Siow Ann; Lee, Jimmy; Li, Zhiqiang; Liu, Jianjun; Iwata, Nakao; Shi, Yongyong; Li, Ming; Su, Bing.

In: PLoS One, Vol. 8, No. 11, e80696, 22.11.2013.

Research output: Contribution to journalArticle

TY - JOUR

T1 - An evaluation of association between a novel hippocampal biology related SNP (rs7294919) and schizophrenia

AU - Liu, Jiewei

AU - Numata, Shusuke

AU - Ikeda, Masashi

AU - Watanabe, Yuichiro

AU - Zheng, Xue Bin

AU - Luo, Xiongjian

AU - Kinoshita, Makoto

AU - Nunokawa, Ayako

AU - Someya, Toshiyuki

AU - Ohmori, Tetsuro

AU - Bei, Jin Xin

AU - Chong, Siow Ann

AU - Lee, Jimmy

AU - Li, Zhiqiang

AU - Liu, Jianjun

AU - Iwata, Nakao

AU - Shi, Yongyong

AU - Li, Ming

AU - Su, Bing

PY - 2013/11/22

Y1 - 2013/11/22

N2 - Recent genetic analyses have implicated several candidate susceptibility variants for schizophrenia. The single nucleotide polymorphism (SNP) rs7294919 is likely a schizophrenia-susceptibility variant according to its significant association with hippocampal volume, hippocampus function, and cognitive performance as well as the nominal association with schizophrenia. However, all previous analyses were conducted only in Europeans, and whether rs7294919 is associated with schizophrenia in other populations are yet to be tested. Here, we conducted a case-control analysis of rs7294919 with schizophrenia in six independent Chinese (N = 3) and Japanese (N = 3) samples, including a total of 7,352 cases and 10,824 controls. The results of our association analysis were not able to confirm the association of rs7294919 with schizophrenia (p = 0.51 in total samples, odds ratio = 1.02 for allele[C]). The absence of rs7294919's association in Chinese and Japanese suggest a potential genetic heterogeneity in the susceptibility of schizophrenia on this locus and also demonstrate the difficulties in replicating associations of schizophrenia across different ethnic populations.

AB - Recent genetic analyses have implicated several candidate susceptibility variants for schizophrenia. The single nucleotide polymorphism (SNP) rs7294919 is likely a schizophrenia-susceptibility variant according to its significant association with hippocampal volume, hippocampus function, and cognitive performance as well as the nominal association with schizophrenia. However, all previous analyses were conducted only in Europeans, and whether rs7294919 is associated with schizophrenia in other populations are yet to be tested. Here, we conducted a case-control analysis of rs7294919 with schizophrenia in six independent Chinese (N = 3) and Japanese (N = 3) samples, including a total of 7,352 cases and 10,824 controls. The results of our association analysis were not able to confirm the association of rs7294919 with schizophrenia (p = 0.51 in total samples, odds ratio = 1.02 for allele[C]). The absence of rs7294919's association in Chinese and Japanese suggest a potential genetic heterogeneity in the susceptibility of schizophrenia on this locus and also demonstrate the difficulties in replicating associations of schizophrenia across different ethnic populations.

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U2 - 10.1371/journal.pone.0080696

DO - 10.1371/journal.pone.0080696

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