TY - JOUR
T1 - An evaluation of polymorphisms in casein kinase 1 delta and epsilon genes in major psychiatric disorders
AU - Matsunaga, Shinji
AU - Ikeda, Masashi
AU - Kishi, Taro
AU - Fukuo, Yasuhisa
AU - Aleksic, Branko
AU - Yoshimura, Reiji
AU - Okochi, Tomo
AU - Yamanouchi, Yoshio
AU - Kinoshita, Yoko
AU - Kawashima, Kunihiro
AU - Umene-Nakano, Wakako
AU - Inada, Toshiya
AU - Kunugi, Hiroshi
AU - Kato, Tadafumi
AU - Yoshikawa, Takeo
AU - Ujike, Hiroshi
AU - Nakamura, Jun
AU - Ozaki, Norio
AU - Kitajima, Tsuyoshi
AU - Iwata, Nakao
N1 - Funding Information:
We thank Ms. M. Miyata and Ms. M. Aizawa for their technical support. This work was supported by research grants from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan ; Ministry of Health, Labor and Welfare of Japan ; Academic Frontier Project for Private Universities, Comparative Cognitive Science Institutes ; Core Research for Evolutional Science and Technology ; Uehara Memorial Foundation; SENSHIN Medical Research Foundation ; Takeda Science Foundation ; Novartis Foundation, Japan ; and Strategic Research Program for Brain Sciences of the MEXT of Japan .
PY - 2012/10/31
Y1 - 2012/10/31
N2 - Disturbances of the circadian rhythm are involved in the pathophysiology of bipolar disorder (BD), schizophrenia (SCZ) and major depressive disorder (MDD). Specifically, because clock gene dysfunction is good candidate for enhancing the susceptibility to these psychiatric disorders, we selected two circadian rhythm-related genes (CSNK1D and CSNK1E) and investigated genetic associations of the genes with these three disorders. None of the SNPs showed a significant association with MDD, but a SNP (rs2075984) in CSNK1E and SNP (rs6502097) in CSNK1D were associated with SCZ (P= 0.0091, uncorrected) and BD (P= 0.030, uncorrected), respectively. To confirm these findings, we analyzed an independent dataset (maximum N= 3815) but found a lack of association (P= 0.63 for rs2075984 and P= 0.61 for rs6502097). The final meta-analysis showed no association between these SNPs with SCZ (P= 0.21) and BD (P= 0.53). These results do not support that genetic variation in CSNK1D and CSNK1E is a susceptibility factor for major psychiatric disorders in the Japanese population.
AB - Disturbances of the circadian rhythm are involved in the pathophysiology of bipolar disorder (BD), schizophrenia (SCZ) and major depressive disorder (MDD). Specifically, because clock gene dysfunction is good candidate for enhancing the susceptibility to these psychiatric disorders, we selected two circadian rhythm-related genes (CSNK1D and CSNK1E) and investigated genetic associations of the genes with these three disorders. None of the SNPs showed a significant association with MDD, but a SNP (rs2075984) in CSNK1E and SNP (rs6502097) in CSNK1D were associated with SCZ (P= 0.0091, uncorrected) and BD (P= 0.030, uncorrected), respectively. To confirm these findings, we analyzed an independent dataset (maximum N= 3815) but found a lack of association (P= 0.63 for rs2075984 and P= 0.61 for rs6502097). The final meta-analysis showed no association between these SNPs with SCZ (P= 0.21) and BD (P= 0.53). These results do not support that genetic variation in CSNK1D and CSNK1E is a susceptibility factor for major psychiatric disorders in the Japanese population.
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U2 - 10.1016/j.neulet.2012.08.070
DO - 10.1016/j.neulet.2012.08.070
M3 - Article
C2 - 22981886
AN - SCOPUS:84867705767
SN - 0304-3940
VL - 529
SP - 66
EP - 69
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1
ER -