An evaluation of polymorphisms in casein kinase 1 delta and epsilon genes in major psychiatric disorders

Shinji Matsunaga, Masashi Ikeda, Taro Kishi, Yasuhisa Fukuo, Branko Aleksic, Reiji Yoshimura, Tomo Okochi, Yoshio Yamanouchi, Yoko Kinoshita, Kunihiro Kawashima, Wakako Umene-Nakano, Toshiya Inada, Hiroshi Kunugi, Tadafumi Kato, Takeo Yoshikawa, Hiroshi Ujike, Jun Nakamura, Norio Ozaki, Tsuyoshi Kitajima, Nakao Iwata

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Abstract

Disturbances of the circadian rhythm are involved in the pathophysiology of bipolar disorder (BD), schizophrenia (SCZ) and major depressive disorder (MDD). Specifically, because clock gene dysfunction is good candidate for enhancing the susceptibility to these psychiatric disorders, we selected two circadian rhythm-related genes (CSNK1D and CSNK1E) and investigated genetic associations of the genes with these three disorders. None of the SNPs showed a significant association with MDD, but a SNP (rs2075984) in CSNK1E and SNP (rs6502097) in CSNK1D were associated with SCZ (P= 0.0091, uncorrected) and BD (P= 0.030, uncorrected), respectively. To confirm these findings, we analyzed an independent dataset (maximum N= 3815) but found a lack of association (P= 0.63 for rs2075984 and P= 0.61 for rs6502097). The final meta-analysis showed no association between these SNPs with SCZ (P= 0.21) and BD (P= 0.53). These results do not support that genetic variation in CSNK1D and CSNK1E is a susceptibility factor for major psychiatric disorders in the Japanese population.

Original languageEnglish
Pages (from-to)66-69
Number of pages4
JournalNeuroscience Letters
Volume529
Issue number1
DOIs
Publication statusPublished - 31-10-2012

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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    Matsunaga, S., Ikeda, M., Kishi, T., Fukuo, Y., Aleksic, B., Yoshimura, R., Okochi, T., Yamanouchi, Y., Kinoshita, Y., Kawashima, K., Umene-Nakano, W., Inada, T., Kunugi, H., Kato, T., Yoshikawa, T., Ujike, H., Nakamura, J., Ozaki, N., Kitajima, T., & Iwata, N. (2012). An evaluation of polymorphisms in casein kinase 1 delta and epsilon genes in major psychiatric disorders. Neuroscience Letters, 529(1), 66-69. https://doi.org/10.1016/j.neulet.2012.08.070