An evolving web of signaling networks regulated by Cripto-1

Tadahiro Nagaoka, Hideaki Karasawa, Nadia Pereira Castro, Maria Cristina Rangel, David S. Salomon, Caterina Bianco

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Over the past few decades, our understanding of the embryonic gene Cripto-1 has considerably advanced through biochemical, cell biology, and animal studies. Cripto-1 performs key functions during embryonic development, while it dramatically disappears in adult tissues, except possibly in adult tissue stem cells. Cripto-1 is re-expressed in human tumors promoting cell proliferation, migration, invasion, epithelial to mesenchymal transition, and tumor angiogenesis. This diversity of biological effects is dependent upon interaction of Cripto-1 with an extensive array of signaling molecules. In fact, Cripto-1 modulates signaling of transforming growth factor-β family members, including Nodal, GDF-1/-3, Activin, and TGF-β1, activates c-src/MAPK/Protein Kinase B (AKT) pathway in a Glypican-1 and GRP78-dependent manner, and cross-talks with erbB4, Wnt/β-catenin, Notch, Caveolin-1, and Apelin/putative receptor protein related to Angiotensin-type I receptor (APJ) pathways. This article provides an updated survey of the various signaling pathways modulated by Cripto-1 with a focus on mechanistic insights in our understanding of the biological function of Cripto-1 in eukaryotic cells.

Original languageEnglish
Pages (from-to)13-21
Number of pages9
JournalGrowth Factors
Volume30
Issue number1
DOIs
Publication statusPublished - 01-02-2012

Fingerprint

Growth Differentiation Factor 3
Growth Differentiation Factor 1
Glypicans
Caveolin 1
Catenins
Activins
Angiotensin I
Proto-Oncogene Proteins c-akt
Adult Stem Cells
Angiotensin Receptors
Epithelial-Mesenchymal Transition
Tumors
Biodiversity
Mitogen-Activated Protein Kinase Kinases
Transforming Growth Factors
Eukaryotic Cells
Cytology
Tissue
Embryonic Development
Cell Movement

All Science Journal Classification (ASJC) codes

  • Endocrinology
  • Clinical Biochemistry
  • Cell Biology

Cite this

Nagaoka, T., Karasawa, H., Castro, N. P., Rangel, M. C., Salomon, D. S., & Bianco, C. (2012). An evolving web of signaling networks regulated by Cripto-1. Growth Factors, 30(1), 13-21. https://doi.org/10.3109/08977194.2011.641962
Nagaoka, Tadahiro ; Karasawa, Hideaki ; Castro, Nadia Pereira ; Rangel, Maria Cristina ; Salomon, David S. ; Bianco, Caterina. / An evolving web of signaling networks regulated by Cripto-1. In: Growth Factors. 2012 ; Vol. 30, No. 1. pp. 13-21.
@article{a991c555f2ca47a287fca7aa56d8d292,
title = "An evolving web of signaling networks regulated by Cripto-1",
abstract = "Over the past few decades, our understanding of the embryonic gene Cripto-1 has considerably advanced through biochemical, cell biology, and animal studies. Cripto-1 performs key functions during embryonic development, while it dramatically disappears in adult tissues, except possibly in adult tissue stem cells. Cripto-1 is re-expressed in human tumors promoting cell proliferation, migration, invasion, epithelial to mesenchymal transition, and tumor angiogenesis. This diversity of biological effects is dependent upon interaction of Cripto-1 with an extensive array of signaling molecules. In fact, Cripto-1 modulates signaling of transforming growth factor-β family members, including Nodal, GDF-1/-3, Activin, and TGF-β1, activates c-src/MAPK/Protein Kinase B (AKT) pathway in a Glypican-1 and GRP78-dependent manner, and cross-talks with erbB4, Wnt/β-catenin, Notch, Caveolin-1, and Apelin/putative receptor protein related to Angiotensin-type I receptor (APJ) pathways. This article provides an updated survey of the various signaling pathways modulated by Cripto-1 with a focus on mechanistic insights in our understanding of the biological function of Cripto-1 in eukaryotic cells.",
author = "Tadahiro Nagaoka and Hideaki Karasawa and Castro, {Nadia Pereira} and Rangel, {Maria Cristina} and Salomon, {David S.} and Caterina Bianco",
year = "2012",
month = "2",
day = "1",
doi = "10.3109/08977194.2011.641962",
language = "English",
volume = "30",
pages = "13--21",
journal = "Growth Factors",
issn = "0897-7194",
publisher = "Informa Healthcare",
number = "1",

}

Nagaoka, T, Karasawa, H, Castro, NP, Rangel, MC, Salomon, DS & Bianco, C 2012, 'An evolving web of signaling networks regulated by Cripto-1', Growth Factors, vol. 30, no. 1, pp. 13-21. https://doi.org/10.3109/08977194.2011.641962

An evolving web of signaling networks regulated by Cripto-1. / Nagaoka, Tadahiro; Karasawa, Hideaki; Castro, Nadia Pereira; Rangel, Maria Cristina; Salomon, David S.; Bianco, Caterina.

In: Growth Factors, Vol. 30, No. 1, 01.02.2012, p. 13-21.

Research output: Contribution to journalArticle

TY - JOUR

T1 - An evolving web of signaling networks regulated by Cripto-1

AU - Nagaoka, Tadahiro

AU - Karasawa, Hideaki

AU - Castro, Nadia Pereira

AU - Rangel, Maria Cristina

AU - Salomon, David S.

AU - Bianco, Caterina

PY - 2012/2/1

Y1 - 2012/2/1

N2 - Over the past few decades, our understanding of the embryonic gene Cripto-1 has considerably advanced through biochemical, cell biology, and animal studies. Cripto-1 performs key functions during embryonic development, while it dramatically disappears in adult tissues, except possibly in adult tissue stem cells. Cripto-1 is re-expressed in human tumors promoting cell proliferation, migration, invasion, epithelial to mesenchymal transition, and tumor angiogenesis. This diversity of biological effects is dependent upon interaction of Cripto-1 with an extensive array of signaling molecules. In fact, Cripto-1 modulates signaling of transforming growth factor-β family members, including Nodal, GDF-1/-3, Activin, and TGF-β1, activates c-src/MAPK/Protein Kinase B (AKT) pathway in a Glypican-1 and GRP78-dependent manner, and cross-talks with erbB4, Wnt/β-catenin, Notch, Caveolin-1, and Apelin/putative receptor protein related to Angiotensin-type I receptor (APJ) pathways. This article provides an updated survey of the various signaling pathways modulated by Cripto-1 with a focus on mechanistic insights in our understanding of the biological function of Cripto-1 in eukaryotic cells.

AB - Over the past few decades, our understanding of the embryonic gene Cripto-1 has considerably advanced through biochemical, cell biology, and animal studies. Cripto-1 performs key functions during embryonic development, while it dramatically disappears in adult tissues, except possibly in adult tissue stem cells. Cripto-1 is re-expressed in human tumors promoting cell proliferation, migration, invasion, epithelial to mesenchymal transition, and tumor angiogenesis. This diversity of biological effects is dependent upon interaction of Cripto-1 with an extensive array of signaling molecules. In fact, Cripto-1 modulates signaling of transforming growth factor-β family members, including Nodal, GDF-1/-3, Activin, and TGF-β1, activates c-src/MAPK/Protein Kinase B (AKT) pathway in a Glypican-1 and GRP78-dependent manner, and cross-talks with erbB4, Wnt/β-catenin, Notch, Caveolin-1, and Apelin/putative receptor protein related to Angiotensin-type I receptor (APJ) pathways. This article provides an updated survey of the various signaling pathways modulated by Cripto-1 with a focus on mechanistic insights in our understanding of the biological function of Cripto-1 in eukaryotic cells.

UR - http://www.scopus.com/inward/record.url?scp=84855847198&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84855847198&partnerID=8YFLogxK

U2 - 10.3109/08977194.2011.641962

DO - 10.3109/08977194.2011.641962

M3 - Article

C2 - 22149969

AN - SCOPUS:84855847198

VL - 30

SP - 13

EP - 21

JO - Growth Factors

JF - Growth Factors

SN - 0897-7194

IS - 1

ER -

Nagaoka T, Karasawa H, Castro NP, Rangel MC, Salomon DS, Bianco C. An evolving web of signaling networks regulated by Cripto-1. Growth Factors. 2012 Feb 1;30(1):13-21. https://doi.org/10.3109/08977194.2011.641962