An immunocompetent child with chromosomally integrated human herpesvirus 6B accidentally identified during the care of Mycoplasma pneumoniae infection

Junko Oikawa, Junko Tanaka, Tetsushi Yoshikawa, Yoshinori Morita, Haruka Hishiki, Naruhiko Ishiwada, Tamae Oe, Hiroki Kurahashi, Yoichi Kohno

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Human herpesvirus 6 (HHV-6) is the only virus known to integrate into human chromosomes and be transmitted from parents to offspring. Less than 1% of the population carries integrated HHV-6 in their genomes. Here,wereport the case of a 9-year-old Japanese girl with an extraordinarily high copynumber of HHV-6B in her genome. The integrated virus genomewas detected by real-time polymerase chain reaction (PCR) in cerebrospinal fluid and serum during the treatment of meningoencephalitis and pneumonia caused by Mycoplasma pneumoniae infection. Furthermore, the HHV-6B genome was detected in hair follicle, plasma, and whole blood in the patient and her mother, but not in the patient's father. Fluorescence in situ hybridization revealed that the viral genome was integrated into chromosome 22. Therefore, these results emphasize the importance of screening for chromosomally integrated HHV-6 prior to starting unnecessary antiviral therapies, particularly for patients harboring HHV-6 with a high copy number.

Original languageEnglish
Pages (from-to)65-67
Number of pages3
JournalJournal of Infection and Chemotherapy
Issue number1
Publication statusPublished - 01-01-2014


All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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