An International Retrospective Observational Study of Liver Functional Deterioration after Repeat Liver Resection for Patients with Hepatocellular Carcinoma

Zenichi Morise; Luca Aldrighetti; Giulio Belli; Francesca Ratti; Tan To Cheung; Chung Mau Lo; Shogo Tanaka; Shoji Kubo; Yukiyasu Okamura; Katsuhiko Uesaka; Kazuteru Monden; Hiroshi Sadamori; Kazuki Hashida; Kazuyuki Kawamoto; Naoto Gotohda; Kuohsin Chen; Akishige Kanazawa; Yutaka Takeda; Yoshiaki Ohmura; Masaki Ueno; Toshiro Ogura; Kyung Suk Suh; Yutaro Kato; Atsushi Sugioka; Andrea Belli; Hiroyuki Nitta; Masafumi Yasunaga; Daniel Cherqui; Nasser Abdul Halim; Alexis Laurent; Hironori Kaneko; Yuichiro Otsuka; Ki Hun Kim; Hwui Dong Cho; Charles Chung Wei Lin; Yusuke Ome; Yasuji Seyama; Roberto I. Troisi; Giammauro Berardi; Fernando Rotellar; Gregory C. Wilson; David A. Geller; Olivier Soubrane; Tomoaki Yoh; Takashi Kaizu; Yusuke Kumamoto; Ho Seong Han; Ela Ekmekcigil; Ibrahim Dagher; David Fuks; Brice Gayet; Joseph F. Buell; Ruben Ciria; Javier Briceno; Nicholas O’rourke; Joel Lewin; Bjorn Edwin; Masahiro Shinoda; Yuta Abe; Mohammed Abu Hilal; Mohammad Alzoubi; Minoru Tanabe; Go Wakabayashi

doi:10.3390/cancers14112598

An International Retrospective Observational Study of Liver Functional Deterioration after Repeat Liver Resection for Patients with Hepatocellular Carcinoma

Zenichi Morise, Luca Aldrighetti, Giulio Belli, Francesca Ratti, Tan To Cheung, Chung Mau Lo, Shogo Tanaka, Shoji Kubo, Yukiyasu Okamura, Katsuhiko Uesaka, Kazuteru Monden, Hiroshi Sadamori, Kazuki Hashida, Kazuyuki Kawamoto, Naoto Gotohda, Kuohsin Chen, Akishige Kanazawa, Yutaka Takeda, Yoshiaki Ohmura, Masaki UenoToshiro Ogura, Kyung Suk Suh, Yutaro Kato, Atsushi Sugioka, Andrea Belli, Hiroyuki Nitta, Masafumi Yasunaga, Daniel Cherqui, Nasser Abdul Halim, Alexis Laurent, Hironori Kaneko, Yuichiro Otsuka, Ki Hun Kim, Hwui Dong Cho, Charles Chung Wei Lin, Yusuke Ome, Yasuji Seyama, Roberto I. Troisi, Giammauro Berardi, Fernando Rotellar, Gregory C. Wilson, David A. Geller, Olivier Soubrane, Tomoaki Yoh, Takashi Kaizu, Yusuke Kumamoto, Ho Seong Han, Ela Ekmekcigil, Ibrahim Dagher, David Fuks, Brice Gayet, Joseph F. Buell, Ruben Ciria, Javier Briceno, Nicholas O’rourke, Joel Lewin, Bjorn Edwin, Masahiro Shinoda, Yuta Abe, Mohammed Abu Hilal, Mohammad Alzoubi, Minoru Tanabe, Go Wakabayashi

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Abstract

Whether albumin and bilirubin levels, platelet counts, ALBI, and ALPlat scores could be useful for the assessment of permanent liver functional deterioration after repeat liver resection was examined, and the deterioration after laparoscopic procedure was evaluated. For 657 patients with liver resection of segment or less in whom results of plasma albumin and bilirubin levels and platelet counts before and 3 months after surgery could be retrieved, liver functional indicators were compared before and after surgery. There were 268 patients who underwent open repeat after previous open liver resection, and 224 patients who underwent laparoscopic repeat after laparoscopic liver resection. The background factors, liver functional indicators before and after surgery and their changes were compared between both groups. Plasma levels of albumin (p = 0.006) and total bilirubin (p = 0.01) were decreased, and ALBI score (p = 0.001) indicated worse liver function after surgery. Laparoscopic group had poorer preoperative performance status and liver function. Changes of liver functional values before and after surgery and overall survivals were similar between laparoscopic and open groups. Plasma levels of albumin and bilirubin and ALBI score could be the indicators for permanent liver functional deterioration after liver resection. Laparoscopic group with poorer conditions showed the similar deterioration of liver function and overall survivals to open group.

Original language	English
Article number	2598
Journal	Cancers
Volume	14
Issue number	11
DOIs	https://doi.org/10.3390/cancers14112598
Publication status	Published - 01-06-2022

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/cancers14112598

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Morise, Z., Aldrighetti, L., Belli, G., Ratti, F., Cheung, T. T., Lo, C. M., Tanaka, S., Kubo, S., Okamura, Y., Uesaka, K., Monden, K., Sadamori, H., Hashida, K., Kawamoto, K., Gotohda, N., Chen, K., Kanazawa, A., Takeda, Y., Ohmura, Y., ... Wakabayashi, G. (2022). An International Retrospective Observational Study of Liver Functional Deterioration after Repeat Liver Resection for Patients with Hepatocellular Carcinoma. Cancers, 14(11), Article 2598. https://doi.org/10.3390/cancers14112598

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title = "An International Retrospective Observational Study of Liver Functional Deterioration after Repeat Liver Resection for Patients with Hepatocellular Carcinoma",

abstract = "Whether albumin and bilirubin levels, platelet counts, ALBI, and ALPlat scores could be useful for the assessment of permanent liver functional deterioration after repeat liver resection was examined, and the deterioration after laparoscopic procedure was evaluated. For 657 patients with liver resection of segment or less in whom results of plasma albumin and bilirubin levels and platelet counts before and 3 months after surgery could be retrieved, liver functional indicators were compared before and after surgery. There were 268 patients who underwent open repeat after previous open liver resection, and 224 patients who underwent laparoscopic repeat after laparoscopic liver resection. The background factors, liver functional indicators before and after surgery and their changes were compared between both groups. Plasma levels of albumin (p = 0.006) and total bilirubin (p = 0.01) were decreased, and ALBI score (p = 0.001) indicated worse liver function after surgery. Laparoscopic group had poorer preoperative performance status and liver function. Changes of liver functional values before and after surgery and overall survivals were similar between laparoscopic and open groups. Plasma levels of albumin and bilirubin and ALBI score could be the indicators for permanent liver functional deterioration after liver resection. Laparoscopic group with poorer conditions showed the similar deterioration of liver function and overall survivals to open group.",

keywords = "laparoscopic liver resection, liver function, liver functional deterioration, overall survival, repeat liver resection",

author = "Zenichi Morise and Luca Aldrighetti and Giulio Belli and Francesca Ratti and Cheung, {Tan To} and Lo, {Chung Mau} and Shogo Tanaka and Shoji Kubo and Yukiyasu Okamura and Katsuhiko Uesaka and Kazuteru Monden and Hiroshi Sadamori and Kazuki Hashida and Kazuyuki Kawamoto and Naoto Gotohda and Kuohsin Chen and Akishige Kanazawa and Yutaka Takeda and Yoshiaki Ohmura and Masaki Ueno and Toshiro Ogura and Suh, {Kyung Suk} and Yutaro Kato and Atsushi Sugioka and Andrea Belli and Hiroyuki Nitta and Masafumi Yasunaga and Daniel Cherqui and Halim, {Nasser Abdul} and Alexis Laurent and Hironori Kaneko and Yuichiro Otsuka and Kim, {Ki Hun} and Cho, {Hwui Dong} and Lin, {Charles Chung Wei} and Yusuke Ome and Yasuji Seyama and Troisi, {Roberto I.} and Giammauro Berardi and Fernando Rotellar and Wilson, {Gregory C.} and Geller, {David A.} and Olivier Soubrane and Tomoaki Yoh and Takashi Kaizu and Yusuke Kumamoto and Han, {Ho Seong} and Ela Ekmekcigil and Ibrahim Dagher and David Fuks and Brice Gayet and Buell, {Joseph F.} and Ruben Ciria and Javier Briceno and Nicholas O{\textquoteright}rourke and Joel Lewin and Bjorn Edwin and Masahiro Shinoda and Yuta Abe and Hilal, {Mohammed Abu} and Mohammad Alzoubi and Minoru Tanabe and Go Wakabayashi",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = jun,

day = "1",

doi = "10.3390/cancers14112598",

language = "English",

volume = "14",

journal = "Cancers",

issn = "2072-6694",

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number = "11",

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Morise, Z, Aldrighetti, L, Belli, G, Ratti, F, Cheung, TT, Lo, CM, Tanaka, S, Kubo, S, Okamura, Y, Uesaka, K, Monden, K, Sadamori, H, Hashida, K, Kawamoto, K, Gotohda, N, Chen, K, Kanazawa, A, Takeda, Y, Ohmura, Y, Ueno, M, Ogura, T, Suh, KS, Kato, Y , Sugioka, A, Belli, A, Nitta, H, Yasunaga, M, Cherqui, D, Halim, NA, Laurent, A, Kaneko, H, Otsuka, Y, Kim, KH, Cho, HD, Lin, CCW, Ome, Y, Seyama, Y, Troisi, RI, Berardi, G, Rotellar, F, Wilson, GC, Geller, DA, Soubrane, O, Yoh, T, Kaizu, T, Kumamoto, Y, Han, HS, Ekmekcigil, E, Dagher, I, Fuks, D, Gayet, B, Buell, JF, Ciria, R, Briceno, J, O’rourke, N, Lewin, J, Edwin, B, Shinoda, M, Abe, Y, Hilal, MA, Alzoubi, M, Tanabe, M & Wakabayashi, G 2022, 'An International Retrospective Observational Study of Liver Functional Deterioration after Repeat Liver Resection for Patients with Hepatocellular Carcinoma', Cancers, vol. 14, no. 11, 2598. https://doi.org/10.3390/cancers14112598

TY - JOUR

T1 - An International Retrospective Observational Study of Liver Functional Deterioration after Repeat Liver Resection for Patients with Hepatocellular Carcinoma

AU - Morise, Zenichi

AU - Aldrighetti, Luca

AU - Belli, Giulio

AU - Ratti, Francesca

AU - Cheung, Tan To

AU - Lo, Chung Mau

AU - Tanaka, Shogo

AU - Kubo, Shoji

AU - Okamura, Yukiyasu

AU - Uesaka, Katsuhiko

AU - Monden, Kazuteru

AU - Sadamori, Hiroshi

AU - Hashida, Kazuki

AU - Kawamoto, Kazuyuki

AU - Gotohda, Naoto

AU - Chen, Kuohsin

AU - Kanazawa, Akishige

AU - Takeda, Yutaka

AU - Ohmura, Yoshiaki

AU - Ueno, Masaki

AU - Ogura, Toshiro

AU - Suh, Kyung Suk

AU - Kato, Yutaro

AU - Sugioka, Atsushi

AU - Belli, Andrea

AU - Nitta, Hiroyuki

AU - Yasunaga, Masafumi

AU - Cherqui, Daniel

AU - Halim, Nasser Abdul

AU - Laurent, Alexis

AU - Kaneko, Hironori

AU - Otsuka, Yuichiro

AU - Kim, Ki Hun

AU - Cho, Hwui Dong

AU - Lin, Charles Chung Wei

AU - Ome, Yusuke

AU - Seyama, Yasuji

AU - Troisi, Roberto I.

AU - Berardi, Giammauro

AU - Rotellar, Fernando

AU - Wilson, Gregory C.

AU - Geller, David A.

AU - Soubrane, Olivier

AU - Yoh, Tomoaki

AU - Kaizu, Takashi

AU - Kumamoto, Yusuke

AU - Han, Ho Seong

AU - Ekmekcigil, Ela

AU - Dagher, Ibrahim

AU - Fuks, David

AU - Gayet, Brice

AU - Buell, Joseph F.

AU - Ciria, Ruben

AU - Briceno, Javier

AU - O’rourke, Nicholas

AU - Lewin, Joel

AU - Edwin, Bjorn

AU - Shinoda, Masahiro

AU - Abe, Yuta

AU - Hilal, Mohammed Abu

AU - Alzoubi, Mohammad

AU - Tanabe, Minoru

AU - Wakabayashi, Go

PY - 2022/6/1

Y1 - 2022/6/1

N2 - Whether albumin and bilirubin levels, platelet counts, ALBI, and ALPlat scores could be useful for the assessment of permanent liver functional deterioration after repeat liver resection was examined, and the deterioration after laparoscopic procedure was evaluated. For 657 patients with liver resection of segment or less in whom results of plasma albumin and bilirubin levels and platelet counts before and 3 months after surgery could be retrieved, liver functional indicators were compared before and after surgery. There were 268 patients who underwent open repeat after previous open liver resection, and 224 patients who underwent laparoscopic repeat after laparoscopic liver resection. The background factors, liver functional indicators before and after surgery and their changes were compared between both groups. Plasma levels of albumin (p = 0.006) and total bilirubin (p = 0.01) were decreased, and ALBI score (p = 0.001) indicated worse liver function after surgery. Laparoscopic group had poorer preoperative performance status and liver function. Changes of liver functional values before and after surgery and overall survivals were similar between laparoscopic and open groups. Plasma levels of albumin and bilirubin and ALBI score could be the indicators for permanent liver functional deterioration after liver resection. Laparoscopic group with poorer conditions showed the similar deterioration of liver function and overall survivals to open group.

AB - Whether albumin and bilirubin levels, platelet counts, ALBI, and ALPlat scores could be useful for the assessment of permanent liver functional deterioration after repeat liver resection was examined, and the deterioration after laparoscopic procedure was evaluated. For 657 patients with liver resection of segment or less in whom results of plasma albumin and bilirubin levels and platelet counts before and 3 months after surgery could be retrieved, liver functional indicators were compared before and after surgery. There were 268 patients who underwent open repeat after previous open liver resection, and 224 patients who underwent laparoscopic repeat after laparoscopic liver resection. The background factors, liver functional indicators before and after surgery and their changes were compared between both groups. Plasma levels of albumin (p = 0.006) and total bilirubin (p = 0.01) were decreased, and ALBI score (p = 0.001) indicated worse liver function after surgery. Laparoscopic group had poorer preoperative performance status and liver function. Changes of liver functional values before and after surgery and overall survivals were similar between laparoscopic and open groups. Plasma levels of albumin and bilirubin and ALBI score could be the indicators for permanent liver functional deterioration after liver resection. Laparoscopic group with poorer conditions showed the similar deterioration of liver function and overall survivals to open group.

KW - laparoscopic liver resection

KW - liver function

KW - liver functional deterioration

KW - overall survival

KW - repeat liver resection

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UR - http://www.scopus.com/inward/citedby.url?scp=85130813390&partnerID=8YFLogxK

U2 - 10.3390/cancers14112598

DO - 10.3390/cancers14112598

M3 - Article

AN - SCOPUS:85130813390

SN - 2072-6694

VL - 14

JO - Cancers

JF - Cancers

IS - 11

M1 - 2598

ER -

An International Retrospective Observational Study of Liver Functional Deterioration after Repeat Liver Resection for Patients with Hepatocellular Carcinoma

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