An investigation of Japanese neonatal and maternal antibody status against pertussis

Koji Takemoto, Naoko Nishimura, Mako Hasegawa, Takuya Akano, Hiroki Takao, Yuto Fukuda, Ayami Yoshikane, Takuto Ito, Shuta Kito, Tomoyasu Noguchi, Kensei Gotoh, Takao Ozaki

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3 Citations (Scopus)


To clarify the pertussis immune status of the Japanese population, we investigated levels of serum pertussis toxin (PT)-specific immunoglobulin G (IgG) antibody in infants and mothers between April 2016 and March 2018. A total of 206 infants (n = 22, < 32 weeks of gestational age [wGA]; n = 70, 32–36 wGA; n = 114, ≥ 37 wGA) and 170 mothers were enrolled. The maternal seroprevalence and antibody geometric mean titer (GMT) were 52.4% and 10.7 EU/mL, respectively. The antibody GMT, seroprevalence, and mean ratio of infant to maternal antibody titers of infants at < 32 wGA were 3.2 EU/mL, 13.6%, and 42.5%, respectively, and were significantly lower than those of infants at 32–36 wGA (9.7 EU/mL, 54.3%, and 110.2%) and infants at ≥ 37 wGA (12.1 EU/ mL, 57.9%, and 112.6%). Of the 21 infants who underwent a second examination, five were positive in the first examination. Of those five, the GMT for PT had decreased by an average of 52.6% at 4.3-week intervals. In the second examination, two infants were seropositive. Approximately half of the mothers and infants were negative for anti-PT antibody. Thus, new vaccination strategies, such as the vaccination of pregnant women, are needed to prevent pertussis infection in early infancy.

Original languageEnglish
Pages (from-to)231-234
Number of pages4
JournalJapanese journal of infectious diseases
Issue number3
Publication statusPublished - 2020

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases


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