An ischemic opening of the blood-brain barrier may deteriorate brain stem auditory evoked potentials following transient hindbrain ischemia in gerbils.

Ryuji Hata, M. Matsumoto, K. Yamamoto, T. Ohtsuki, S. Ogawa, N. Handa, T. Kubo, T. Matsunaga, T. Nishimura, T. Kamada

Research output: Contribution to journalArticle

Abstract

To clarify the effect of vasogenic brain edema on the brainstem, the relationships between waveform changes in brainstem auditory evoked potentials (BAEP) and blood-brain barrier (BBB) disturbance following transient hindbrain ischemia were investigated. Hindbrain ischemia was induced in gerbils by bilateral occlusion of the vertebral arteries. The animals were divided into three groups subjected to 0, 5, and 30 min of bilateral vertebral occlusion (BVO-0',-5', and -30' groups; n = 4 in each group). Two hours after recirculation, Evans blue (EB) solution was injected into the saphenous vein. The brains were removed after 30 min of circulation, and all areas stained macroscopically by EB were noted and recorded. During hindbrain ischemia, BAEP disappeared within 3 min. In the BVO-5' group, BAEP reappeared and returned to normal within 10 min after reperfusion, whereas in the BVO-30' group, BAEP never returned to normal and finally disappeared within 30 min after reperfusion. In the BVO-5' group, no EB staining was visible. On the other hand, in the BVO-30' group, EB staining was seen in the medial part of the tegmentum in the midbrain in two animals, and around the vestibular nucleus in the lateral parts of the pons in three. These results demonstrate the close relationship between the reversibility of ischemia-induced changes in BAEP and BBB disturbance in the brainstem.

Original languageEnglish
Pages (from-to)197-199
Number of pages3
JournalActa neurochirurgica. Supplementum
Volume60
Publication statusPublished - 01-01-1994

Fingerprint

Rhombencephalon
Brain Stem Auditory Evoked Potentials
Gerbillinae
Blood-Brain Barrier
Evans Blue
Ischemia
Brain Stem
Reperfusion
Lateral Vestibular Nucleus
Tegmentum Mesencephali
Staining and Labeling
Pons
Vertebral Artery
Brain Edema
Saphenous Vein
Brain

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

Cite this

Hata, Ryuji ; Matsumoto, M. ; Yamamoto, K. ; Ohtsuki, T. ; Ogawa, S. ; Handa, N. ; Kubo, T. ; Matsunaga, T. ; Nishimura, T. ; Kamada, T. / An ischemic opening of the blood-brain barrier may deteriorate brain stem auditory evoked potentials following transient hindbrain ischemia in gerbils. In: Acta neurochirurgica. Supplementum. 1994 ; Vol. 60. pp. 197-199.
@article{8acb931011fb4843a814f293b8885a91,
title = "An ischemic opening of the blood-brain barrier may deteriorate brain stem auditory evoked potentials following transient hindbrain ischemia in gerbils.",
abstract = "To clarify the effect of vasogenic brain edema on the brainstem, the relationships between waveform changes in brainstem auditory evoked potentials (BAEP) and blood-brain barrier (BBB) disturbance following transient hindbrain ischemia were investigated. Hindbrain ischemia was induced in gerbils by bilateral occlusion of the vertebral arteries. The animals were divided into three groups subjected to 0, 5, and 30 min of bilateral vertebral occlusion (BVO-0',-5', and -30' groups; n = 4 in each group). Two hours after recirculation, Evans blue (EB) solution was injected into the saphenous vein. The brains were removed after 30 min of circulation, and all areas stained macroscopically by EB were noted and recorded. During hindbrain ischemia, BAEP disappeared within 3 min. In the BVO-5' group, BAEP reappeared and returned to normal within 10 min after reperfusion, whereas in the BVO-30' group, BAEP never returned to normal and finally disappeared within 30 min after reperfusion. In the BVO-5' group, no EB staining was visible. On the other hand, in the BVO-30' group, EB staining was seen in the medial part of the tegmentum in the midbrain in two animals, and around the vestibular nucleus in the lateral parts of the pons in three. These results demonstrate the close relationship between the reversibility of ischemia-induced changes in BAEP and BBB disturbance in the brainstem.",
author = "Ryuji Hata and M. Matsumoto and K. Yamamoto and T. Ohtsuki and S. Ogawa and N. Handa and T. Kubo and T. Matsunaga and T. Nishimura and T. Kamada",
year = "1994",
month = "1",
day = "1",
language = "English",
volume = "60",
pages = "197--199",
journal = "Acta Neurochirurgica, Supplement",
issn = "0065-1419",
publisher = "Springer Wien",

}

Hata, R, Matsumoto, M, Yamamoto, K, Ohtsuki, T, Ogawa, S, Handa, N, Kubo, T, Matsunaga, T, Nishimura, T & Kamada, T 1994, 'An ischemic opening of the blood-brain barrier may deteriorate brain stem auditory evoked potentials following transient hindbrain ischemia in gerbils.', Acta neurochirurgica. Supplementum, vol. 60, pp. 197-199.

An ischemic opening of the blood-brain barrier may deteriorate brain stem auditory evoked potentials following transient hindbrain ischemia in gerbils. / Hata, Ryuji; Matsumoto, M.; Yamamoto, K.; Ohtsuki, T.; Ogawa, S.; Handa, N.; Kubo, T.; Matsunaga, T.; Nishimura, T.; Kamada, T.

In: Acta neurochirurgica. Supplementum, Vol. 60, 01.01.1994, p. 197-199.

Research output: Contribution to journalArticle

TY - JOUR

T1 - An ischemic opening of the blood-brain barrier may deteriorate brain stem auditory evoked potentials following transient hindbrain ischemia in gerbils.

AU - Hata, Ryuji

AU - Matsumoto, M.

AU - Yamamoto, K.

AU - Ohtsuki, T.

AU - Ogawa, S.

AU - Handa, N.

AU - Kubo, T.

AU - Matsunaga, T.

AU - Nishimura, T.

AU - Kamada, T.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - To clarify the effect of vasogenic brain edema on the brainstem, the relationships between waveform changes in brainstem auditory evoked potentials (BAEP) and blood-brain barrier (BBB) disturbance following transient hindbrain ischemia were investigated. Hindbrain ischemia was induced in gerbils by bilateral occlusion of the vertebral arteries. The animals were divided into three groups subjected to 0, 5, and 30 min of bilateral vertebral occlusion (BVO-0',-5', and -30' groups; n = 4 in each group). Two hours after recirculation, Evans blue (EB) solution was injected into the saphenous vein. The brains were removed after 30 min of circulation, and all areas stained macroscopically by EB were noted and recorded. During hindbrain ischemia, BAEP disappeared within 3 min. In the BVO-5' group, BAEP reappeared and returned to normal within 10 min after reperfusion, whereas in the BVO-30' group, BAEP never returned to normal and finally disappeared within 30 min after reperfusion. In the BVO-5' group, no EB staining was visible. On the other hand, in the BVO-30' group, EB staining was seen in the medial part of the tegmentum in the midbrain in two animals, and around the vestibular nucleus in the lateral parts of the pons in three. These results demonstrate the close relationship between the reversibility of ischemia-induced changes in BAEP and BBB disturbance in the brainstem.

AB - To clarify the effect of vasogenic brain edema on the brainstem, the relationships between waveform changes in brainstem auditory evoked potentials (BAEP) and blood-brain barrier (BBB) disturbance following transient hindbrain ischemia were investigated. Hindbrain ischemia was induced in gerbils by bilateral occlusion of the vertebral arteries. The animals were divided into three groups subjected to 0, 5, and 30 min of bilateral vertebral occlusion (BVO-0',-5', and -30' groups; n = 4 in each group). Two hours after recirculation, Evans blue (EB) solution was injected into the saphenous vein. The brains were removed after 30 min of circulation, and all areas stained macroscopically by EB were noted and recorded. During hindbrain ischemia, BAEP disappeared within 3 min. In the BVO-5' group, BAEP reappeared and returned to normal within 10 min after reperfusion, whereas in the BVO-30' group, BAEP never returned to normal and finally disappeared within 30 min after reperfusion. In the BVO-5' group, no EB staining was visible. On the other hand, in the BVO-30' group, EB staining was seen in the medial part of the tegmentum in the midbrain in two animals, and around the vestibular nucleus in the lateral parts of the pons in three. These results demonstrate the close relationship between the reversibility of ischemia-induced changes in BAEP and BBB disturbance in the brainstem.

UR - http://www.scopus.com/inward/record.url?scp=0028189687&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028189687&partnerID=8YFLogxK

M3 - Article

C2 - 7976544

AN - SCOPUS:0028189687

VL - 60

SP - 197

EP - 199

JO - Acta Neurochirurgica, Supplement

JF - Acta Neurochirurgica, Supplement

SN - 0065-1419

ER -