An ultrastructural study of subacute necrotizing lymphadenitis

M. Imamura, H. Ueno, Akihiro Matsuura, H. Kamiya, T. Suzuki, K. Kikuchi, T. Onoe

Research output: Contribution to journalArticle

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Abstract

Fifteen cases of a unique lymphadenitis called subacute necrotizing lymphadenitis were studied electron-microscopically. The large lymphoreticular cells proliferating at cortical or paracortical areas of the lymph nodes mainly consisted of immunoblasts and histiocytoid cells, which were characterized by numerous intracytoplasmic myelinlike inclusions. Such histiocytoid cells seemed to be derived from the immunoblasts. Tubuloreticular structures, which had been often noticed within endothelial cells or lymphocytes of the patients with systemic lupus erythematosus (SLE) or SLE-related diseases, were also observed with high frequency in most cases examined. They were present within the cytoplasm of immunoblasts, endothelial cells, and histiocytoid cells. Immunoblasts in mitosis occasionally contained these structures. We offer the hypothesis that subacute necrotizing lymphadenitis with still unknown etiology may reflect a self-limited SLE-like autoimmune condition induced by virus-infected transformed lymphocytes.

Original languageEnglish
Pages (from-to)292-299
Number of pages8
JournalAmerican Journal of Pathology
Volume107
Issue number3
Publication statusPublished - 20-09-1982

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Lymphadenitis
Systemic Lupus Erythematosus
Endothelial Cells
Lymphocytes
Mitosis
Cytoplasm
Lymph Nodes
Electrons
Viruses

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Imamura, M., Ueno, H., Matsuura, A., Kamiya, H., Suzuki, T., Kikuchi, K., & Onoe, T. (1982). An ultrastructural study of subacute necrotizing lymphadenitis. American Journal of Pathology, 107(3), 292-299.
Imamura, M. ; Ueno, H. ; Matsuura, Akihiro ; Kamiya, H. ; Suzuki, T. ; Kikuchi, K. ; Onoe, T. / An ultrastructural study of subacute necrotizing lymphadenitis. In: American Journal of Pathology. 1982 ; Vol. 107, No. 3. pp. 292-299.
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Imamura, M, Ueno, H, Matsuura, A, Kamiya, H, Suzuki, T, Kikuchi, K & Onoe, T 1982, 'An ultrastructural study of subacute necrotizing lymphadenitis', American Journal of Pathology, vol. 107, no. 3, pp. 292-299.

An ultrastructural study of subacute necrotizing lymphadenitis. / Imamura, M.; Ueno, H.; Matsuura, Akihiro; Kamiya, H.; Suzuki, T.; Kikuchi, K.; Onoe, T.

In: American Journal of Pathology, Vol. 107, No. 3, 20.09.1982, p. 292-299.

Research output: Contribution to journalArticle

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Imamura M, Ueno H, Matsuura A, Kamiya H, Suzuki T, Kikuchi K et al. An ultrastructural study of subacute necrotizing lymphadenitis. American Journal of Pathology. 1982 Sep 20;107(3):292-299.