Analgesic effect of oral tramadol on transrectal ultrasound-guided needle biopsy of the prostate in a randomized double-blind study

Hayahito Nomi, Haruhito Azuma, Naoki Segawa, Teruo Inamoto, Kiyoshi Takahara, Kazumasa Komura, Kohei Koyama, Takanobu Ubai, Yoji Katsuoka

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Abstract

A total of 121 Japanese patients scheduled for prostate biopsy were randomly and double-blindly assigned to be given a single oral dose of 100 mg Tramadol mixed with 20 ml of sugar syrup or placebo, 30 minutes before the procedure. Pain severity was measured by verbal rating scale (VRS) and visual analog scales (VAS). We also analyzed cardio-respiratory parameters and complications. Of 121 patients, 117 replied validly to VRS and VAS ; and 91 of 117 patients replied to the cohort questionnaire for analysis of the late disorder, patient's impression, prolonged pain and past history of hemorrhoid treatment. Tramadol showed no significant effect on pain severity indicated by VRS and VAS, and no change in cardio-respiratory parameters. Furthermore, 70 patients without a history of hemorrhoid treatment, showed no significant analgesic benefits of Tramadol during the biopsy. In total, 3 patients had side effects of vomiting (CTCAE : grade 1)6), which subsided spontaneously. The oral administration of a single dose of 100 mg Tramadol 30 minutes before a transrectal needle biopsy of the prostate was safe, but was not effective to calm down the pain severity.

Original languageEnglish
Pages (from-to)425-428
Number of pages4
JournalActa Urologica Japonica
Volume57
Issue number8
Publication statusPublished - 31-08-2011

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Tramadol
Needle Biopsy
Double-Blind Method
Analgesics
Prostate
Visual Analog Scale
Pain
Hemorrhoids
Biopsy
Vomiting
Oral Administration
Cohort Studies
Placebos
Therapeutics

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Nomi, Hayahito ; Azuma, Haruhito ; Segawa, Naoki ; Inamoto, Teruo ; Takahara, Kiyoshi ; Komura, Kazumasa ; Koyama, Kohei ; Ubai, Takanobu ; Katsuoka, Yoji. / Analgesic effect of oral tramadol on transrectal ultrasound-guided needle biopsy of the prostate in a randomized double-blind study. In: Acta Urologica Japonica. 2011 ; Vol. 57, No. 8. pp. 425-428.
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abstract = "A total of 121 Japanese patients scheduled for prostate biopsy were randomly and double-blindly assigned to be given a single oral dose of 100 mg Tramadol mixed with 20 ml of sugar syrup or placebo, 30 minutes before the procedure. Pain severity was measured by verbal rating scale (VRS) and visual analog scales (VAS). We also analyzed cardio-respiratory parameters and complications. Of 121 patients, 117 replied validly to VRS and VAS ; and 91 of 117 patients replied to the cohort questionnaire for analysis of the late disorder, patient's impression, prolonged pain and past history of hemorrhoid treatment. Tramadol showed no significant effect on pain severity indicated by VRS and VAS, and no change in cardio-respiratory parameters. Furthermore, 70 patients without a history of hemorrhoid treatment, showed no significant analgesic benefits of Tramadol during the biopsy. In total, 3 patients had side effects of vomiting (CTCAE : grade 1)6), which subsided spontaneously. The oral administration of a single dose of 100 mg Tramadol 30 minutes before a transrectal needle biopsy of the prostate was safe, but was not effective to calm down the pain severity.",
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Nomi, H, Azuma, H, Segawa, N, Inamoto, T, Takahara, K, Komura, K, Koyama, K, Ubai, T & Katsuoka, Y 2011, 'Analgesic effect of oral tramadol on transrectal ultrasound-guided needle biopsy of the prostate in a randomized double-blind study', Acta Urologica Japonica, vol. 57, no. 8, pp. 425-428.

Analgesic effect of oral tramadol on transrectal ultrasound-guided needle biopsy of the prostate in a randomized double-blind study. / Nomi, Hayahito; Azuma, Haruhito; Segawa, Naoki; Inamoto, Teruo; Takahara, Kiyoshi; Komura, Kazumasa; Koyama, Kohei; Ubai, Takanobu; Katsuoka, Yoji.

In: Acta Urologica Japonica, Vol. 57, No. 8, 31.08.2011, p. 425-428.

Research output: Contribution to journalArticle

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T1 - Analgesic effect of oral tramadol on transrectal ultrasound-guided needle biopsy of the prostate in a randomized double-blind study

AU - Nomi, Hayahito

AU - Azuma, Haruhito

AU - Segawa, Naoki

AU - Inamoto, Teruo

AU - Takahara, Kiyoshi

AU - Komura, Kazumasa

AU - Koyama, Kohei

AU - Ubai, Takanobu

AU - Katsuoka, Yoji

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Y1 - 2011/8/31

N2 - A total of 121 Japanese patients scheduled for prostate biopsy were randomly and double-blindly assigned to be given a single oral dose of 100 mg Tramadol mixed with 20 ml of sugar syrup or placebo, 30 minutes before the procedure. Pain severity was measured by verbal rating scale (VRS) and visual analog scales (VAS). We also analyzed cardio-respiratory parameters and complications. Of 121 patients, 117 replied validly to VRS and VAS ; and 91 of 117 patients replied to the cohort questionnaire for analysis of the late disorder, patient's impression, prolonged pain and past history of hemorrhoid treatment. Tramadol showed no significant effect on pain severity indicated by VRS and VAS, and no change in cardio-respiratory parameters. Furthermore, 70 patients without a history of hemorrhoid treatment, showed no significant analgesic benefits of Tramadol during the biopsy. In total, 3 patients had side effects of vomiting (CTCAE : grade 1)6), which subsided spontaneously. The oral administration of a single dose of 100 mg Tramadol 30 minutes before a transrectal needle biopsy of the prostate was safe, but was not effective to calm down the pain severity.

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