Analysis of chronic graft-versus-host disease in patients after bone marrow transplantation from HLA-identical siblings

Y. Akatsuka, S. Tsuzuki, T. Sugihara, S. Minami, Y. Kodera, N. Hirabayashi

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Abstract

The incidence of chronic GVHD, involved organs, and outcome were evaluated in 59 patients aged 15 years or more who survived for 2 months or more after HLA-matched bone marrow transplantation. The incidence of chronic GVHD was 65.3%. The incidence was not correlated with the age at the time of transplantation, underlying disease, or the method to prevent GVHD (group treated with MTX alone and CSP-treated group). Concerning the degree of organ involvement, the CSP-treated group more frequently showed slight involvement and, especially a significantly lower incidence of dryness of the eyeballs. According to organs, the oral cavity was most frequently involved (87%), followed in order by the liver (74%), skin (52%), and the eyes (30%). The oral cavity alone was involved in 6 patients, and the outcome was generally good. The outcome of multi-organ involvement of chronic GVHD was poor, and the major causes of death were interstitial pneumonia and sepsis. Even of patients who did not develop chronic GVHD, 25% showed dryness of the eyeballs and oral cavity. Biopsy and careful observation of the clinical course are needed for diagnosing GVHD.

Original languageEnglish
Pages (from-to)1517-1524
Number of pages8
Journal[Rinshō ketsueki] The Japanese journal of clinical hematology
Volume34
Issue number12
Publication statusPublished - 12-1993

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

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