Analysis of chronic graft-versus-host disease in patients after bone marrow transplantation from HLA-identical siblings

Yoshiki Akatsuka, S. Tsuzuki, T. Sugihara, S. Minami, Y. Kodera, N. Hirabayashi

Research output: Contribution to journalArticle

Abstract

The incidence of chronic GVHD, involved organs, and outcome were evaluated in 59 patients aged 15 years or more who survived for 2 months or more after HLA-matched bone marrow transplantation. The incidence of chronic GVHD was 65.3%. The incidence was not correlated with the age at the time of transplantation, underlying disease, or the method to prevent GVHD (group treated with MTX alone and CSP-treated group). Concerning the degree of organ involvement, the CSP-treated group more frequently showed slight involvement and, especially a significantly lower incidence of dryness of the eyeballs. According to organs, the oral cavity was most frequently involved (87%), followed in order by the liver (74%), skin (52%), and the eyes (30%). The oral cavity alone was involved in 6 patients, and the outcome was generally good. The outcome of multi-organ involvement of chronic GVHD was poor, and the major causes of death were interstitial pneumonia and sepsis. Even of patients who did not develop chronic GVHD, 25% showed dryness of the eyeballs and oral cavity. Biopsy and careful observation of the clinical course are needed for diagnosing GVHD.

Original languageEnglish
Pages (from-to)1517-1524
Number of pages8
Journal[Rinshō ketsueki] The Japanese journal of clinical hematology
Volume34
Issue number12
Publication statusPublished - 01-01-1993
Externally publishedYes

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Graft vs Host Disease
Bone Marrow Transplantation
Siblings
Mouth
Incidence
Interstitial Lung Diseases
Cause of Death
Sepsis
Transplantation
Observation
Biopsy
Skin
Liver

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Akatsuka, Yoshiki ; Tsuzuki, S. ; Sugihara, T. ; Minami, S. ; Kodera, Y. ; Hirabayashi, N. / Analysis of chronic graft-versus-host disease in patients after bone marrow transplantation from HLA-identical siblings. In: [Rinshō ketsueki] The Japanese journal of clinical hematology. 1993 ; Vol. 34, No. 12. pp. 1517-1524.
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Analysis of chronic graft-versus-host disease in patients after bone marrow transplantation from HLA-identical siblings. / Akatsuka, Yoshiki; Tsuzuki, S.; Sugihara, T.; Minami, S.; Kodera, Y.; Hirabayashi, N.

In: [Rinshō ketsueki] The Japanese journal of clinical hematology, Vol. 34, No. 12, 01.01.1993, p. 1517-1524.

Research output: Contribution to journalArticle

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AU - Sugihara, T.

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AU - Kodera, Y.

AU - Hirabayashi, N.

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