TY - JOUR
T1 - Analysis of gene-expression profiles by oligonucleotide microarray in children with influenza
AU - Kawada, Jun Ichi
AU - Kimura, Hiroshi
AU - Kamachi, Yoshiro
AU - Nishikawa, Kazuo
AU - Taniguchi, Mariko
AU - Nagaoka, Kayuri
AU - Kurahashi, Hiroki
AU - Kojima, Seiji
AU - Morishima, Tsuneo
PY - 2006/6
Y1 - 2006/6
N2 - In order to clarify the mechanism of the host response to influenza virus, gene-expression profiles of peripheral blood obtained from paediatric patients with influenza were investigated by oligonucleotide microarray. In the acute phase of influenza, 200 genes were upregulated and 20 genes were downregulated compared with their expression in the convalescent phase. Interferon-regulated genes, such as interferon-induced protein with tetratricopeptide repeats 2 (IFIT2) and vipirin, were strongly upregulated in the acute phase. Gene ontology analysis showed that immune response genes were highly overrepresented among the upregulated genes. Gene-expression profiles of influenza patients with and without febrile convulsion were also studied. In patients with febrile convulsion, 22 genes were upregulated and five were downregulated compared with their expression in patients without febrile convulsion. These results should help to clarify the pathogenesis of influenza and its neurological complications.
AB - In order to clarify the mechanism of the host response to influenza virus, gene-expression profiles of peripheral blood obtained from paediatric patients with influenza were investigated by oligonucleotide microarray. In the acute phase of influenza, 200 genes were upregulated and 20 genes were downregulated compared with their expression in the convalescent phase. Interferon-regulated genes, such as interferon-induced protein with tetratricopeptide repeats 2 (IFIT2) and vipirin, were strongly upregulated in the acute phase. Gene ontology analysis showed that immune response genes were highly overrepresented among the upregulated genes. Gene-expression profiles of influenza patients with and without febrile convulsion were also studied. In patients with febrile convulsion, 22 genes were upregulated and five were downregulated compared with their expression in patients without febrile convulsion. These results should help to clarify the pathogenesis of influenza and its neurological complications.
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U2 - 10.1099/vir.0.81670-0
DO - 10.1099/vir.0.81670-0
M3 - Article
C2 - 16690933
AN - SCOPUS:33744807432
SN - 0022-1317
VL - 87
SP - 1677
EP - 1683
JO - Journal of General Virology
JF - Journal of General Virology
IS - 6
ER -