@article{02e9b5b05b784c1b9a1d91ec2a7baec1,
title = "Analysis of mitochondrial DNA variants in Japanese patients with schizophrenia",
abstract = "To test the hypothesis that mitochondrial DNA (mtDNA) variants contribute to the susceptibility to schizophrenia, we sequenced the entire mtDNAs from 93 Japanese schizophrenic patients. Three non-synonymous homoplasmic variants in subunit six of the ATP synthase (MT-ATP6) gene that were detected only in patients but not in controls were suggested to be slightly deleterious, because (1) their original amino acid residues (AA) were highly conserved and (2) the physicochemical differences between the original and altered AA were relatively high. In addition, we detected three novel heteroplasmic variants that were potentially pathogenic. Although functional analysis is needed, rare variants in the mtDNA may convey susceptibility to schizophrenia.",
author = "Hitomi Ueno and Yutaka Nishigaki and Kong, {Qing Peng} and Noriyuki Fuku and Shuji Kojima and Nakao Iwata and Norio Ozaki and Masashi Tanaka",
note = "Funding Information: This work was supported in part by the Support Project for Database Development from the Japan Science and Technology Corporation (to M.T.); a Grant-in-Aid for Scientific Research [C-18590317 to Y.N., and C2-10832009 and A (2)-15200051 to M.T.], a Grant-in-Aid for Young Scientists (B-18700541 to N.F.), and a Grant-in-Aid for Exploratory Research (20650113 to N.F.) from the Ministry of Education, Culture, Sports, Science and Technology; by a grant from the Third-Term Comprehensive 10-year Strategy for Cancer Control (to M.T.); by Grant 20B-13 from the program Research Grants for Nervous and Mental Disorders of the Ministry of Health, Labour, and Welfare (to M.T.); and by grants for scientific research from the Kao Research Council for the study of Healthcare Science (to Y.N.) and from the Takeda Science Foundation (to Y.N. and to M.T.) and Sankyo Foundation of Life Science (to Y.N.).",
year = "2009",
month = nov,
doi = "10.1016/j.mito.2009.06.003",
language = "English",
volume = "9",
pages = "385--393",
journal = "Mitochondrion",
issn = "1567-7249",
publisher = "Elsevier B.V.",
number = "6",
}