Analysis of rotavirus antigenemia in hematopoietic stem cell transplant recipients

K. Sugata, K. Taniguchi, A. Yui, H. Nakai, Y. Asano, Shuji Hashimoto, Masaru Ihira, H. Yagasaki, Y. Takahashi, S. Kojima, K. Matsumoto, K. Kato, Tetsushi Yoshikawa

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Systemic rotavirus infection, such as rotavirus antigenemia, has been found in immunocompetent rotavirus gastroenteritis patients. However, the pathogenesis of rotavirus infection in immunocompromised transplant recipients remains unclear. Enzyme-linked immunosorbent assay was used to measure rotavirus antigen levels in serially collected serum samples obtained from 62 pediatric patients receiving allogeneic hematopoietic stem cell transplants (HSCT). Rotavirus antigen was detected in 43 (6.8%) of 633 serum samples (8 of 62 patients). The duration of rotavirus antigenemia ranged between 1 and 10 weeks, and diarrhea was concurrent with rotavirus antigenemia in Cases 3, 6, 7, and 8. The level of viral antigen in the transplant recipients (0.19 ± 0.20) was significantly lower than that observed in serum samples collected from immunocompetent patients on either day 1 (0.49 ± 0.18, P = 0.0011) or day 3 (0.63 ± 0.09, P = 0.0005). A patient who received a graft from a human leukocyte antigen (HLA)-mismatched donor was at significant risk for rotavirus antigenemia (P = 0.024; odds ratio = 9.44) in comparison to patients who received grafts from HLA-matched donors. Although the duration of antigenemia was clearly longer in HSCT patients than in immunocompetent rotavirus gastroenteritis patients, the levels of viral antigen were not as high. Therefore, mismatched HLA may be a risk factor for rotavirus antigenemia after HSCT.

Original languageEnglish
Pages (from-to)49-56
Number of pages8
JournalTransplant Infectious Disease
Volume14
Issue number1
DOIs
Publication statusPublished - 01-02-2012

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Rotavirus
Hematopoietic Stem Cells
Transplants
HLA Antigens
Rotavirus Infections
Viral Antigens
Gastroenteritis
Serum
Tissue Donors
Transplant Recipients
Antigens
Diarrhea
Enzyme-Linked Immunosorbent Assay
Odds Ratio
Pediatrics

All Science Journal Classification (ASJC) codes

  • Transplantation
  • Infectious Diseases

Cite this

Sugata, K. ; Taniguchi, K. ; Yui, A. ; Nakai, H. ; Asano, Y. ; Hashimoto, Shuji ; Ihira, Masaru ; Yagasaki, H. ; Takahashi, Y. ; Kojima, S. ; Matsumoto, K. ; Kato, K. ; Yoshikawa, Tetsushi. / Analysis of rotavirus antigenemia in hematopoietic stem cell transplant recipients. In: Transplant Infectious Disease. 2012 ; Vol. 14, No. 1. pp. 49-56.
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Sugata, K, Taniguchi, K, Yui, A, Nakai, H, Asano, Y, Hashimoto, S, Ihira, M, Yagasaki, H, Takahashi, Y, Kojima, S, Matsumoto, K, Kato, K & Yoshikawa, T 2012, 'Analysis of rotavirus antigenemia in hematopoietic stem cell transplant recipients', Transplant Infectious Disease, vol. 14, no. 1, pp. 49-56. https://doi.org/10.1111/j.1399-3062.2011.00668.x

Analysis of rotavirus antigenemia in hematopoietic stem cell transplant recipients. / Sugata, K.; Taniguchi, K.; Yui, A.; Nakai, H.; Asano, Y.; Hashimoto, Shuji; Ihira, Masaru; Yagasaki, H.; Takahashi, Y.; Kojima, S.; Matsumoto, K.; Kato, K.; Yoshikawa, Tetsushi.

In: Transplant Infectious Disease, Vol. 14, No. 1, 01.02.2012, p. 49-56.

Research output: Contribution to journalArticle

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AU - Taniguchi, K.

AU - Yui, A.

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AU - Asano, Y.

AU - Hashimoto, Shuji

AU - Ihira, Masaru

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AU - Takahashi, Y.

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AU - Kato, K.

AU - Yoshikawa, Tetsushi

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