Analysis of the Origin of Double Mosaic Aneuploidy in Two Cases

Takema Kato, Miki Kawai, Shunsuke Miyai, Fumihiko Suzuki, Makiko Tsutsumi, Seiji Mizuno, Toshiro Ikeda, Hiroki Kurahashi

Research output: Contribution to journalArticle

Abstract

We present 2 cases of double mosaic aneuploidy harboring 2 or more different aneuploid cell lines, but no line with a normal chromosome constitution. One of these cases presented mosaicism of sex chromosome aneuploid cell lines (47,XXX/45,X) along with another line containing an autosomal trisomy (47,XX,+8), while the other case showed mosaicism of 2 different autosomal trisomy cell lines (47,XY,+5 and 47,XY,+8). To elucidate the mechanisms underlying these mosaicisms, we conducted molecular cytogenetic analyses. Genotyping data from the SNP microarray indicated that 2 sequential meiotic or early postzygotic segregation errors likely had occurred followed by natural selection. These cases suggest that frequent segregation errors and selection events in the meiotic and early postzygotic stages lead to this condition.

Original languageEnglish
JournalCytogenetic and Genome Research
DOIs
Publication statusAccepted/In press - 01-01-2020

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All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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