Angiogenesis in response to hypoxia

Y. Ozawa; K. Tsubota; H. Okano

doi:10.1016/B978-0-12-374203-2.00122-6

Angiogenesis in response to hypoxia

Y. Ozawa, K. Tsubota, H. Okano

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Angiogenesis is regulated by the balance of angiogenic and anti-angiogenic factors through multiple pathways. In this article, we focus on hypoxia that regulates angiogenic factors. Two potent angiogenic factors - vascular endothelial growth factor (VEGF) and erythropoietin (Epo) - are regulated by transcription factors called hypoxia-inducible factors (HIFs). Several pathways that regulate the HIFs under hypoxic conditions are described. Then, we review the mechanisms, that is, involvement of VEGF and Epo, in pathological angiogenesis in the retina and describe supporting experimental data obtained from model animals, in addition to human clinical data. We also discuss how hypoxia regulates vascular development in the retina.

Original language	English
Title of host publication	Encyclopedia of the Eye
Publisher	Elsevier
Pages	88-92
Number of pages	5
ISBN (Electronic)	9780123742032
ISBN (Print)	9780123741981
DOIs	https://doi.org/10.1016/B978-0-12-374203-2.00122-6
Publication status	Published - 01-01-2010
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Medicine

Access to Document

10.1016/B978-0-12-374203-2.00122-6

Cite this

@inbook{d7704745eea149729b008cccf62df3af,

title = "Angiogenesis in response to hypoxia",

abstract = "Angiogenesis is regulated by the balance of angiogenic and anti-angiogenic factors through multiple pathways. In this article, we focus on hypoxia that regulates angiogenic factors. Two potent angiogenic factors - vascular endothelial growth factor (VEGF) and erythropoietin (Epo) - are regulated by transcription factors called hypoxia-inducible factors (HIFs). Several pathways that regulate the HIFs under hypoxic conditions are described. Then, we review the mechanisms, that is, involvement of VEGF and Epo, in pathological angiogenesis in the retina and describe supporting experimental data obtained from model animals, in addition to human clinical data. We also discuss how hypoxia regulates vascular development in the retina.",

author = "Y. Ozawa and K. Tsubota and H. Okano",

year = "2010",

month = jan,

day = "1",

doi = "10.1016/B978-0-12-374203-2.00122-6",

language = "English",

isbn = "9780123741981",

pages = "88--92",

booktitle = "Encyclopedia of the Eye",

publisher = "Elsevier",

address = "Netherlands",

}

TY - CHAP

T1 - Angiogenesis in response to hypoxia

AU - Ozawa, Y.

AU - Tsubota, K.

AU - Okano, H.

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Angiogenesis is regulated by the balance of angiogenic and anti-angiogenic factors through multiple pathways. In this article, we focus on hypoxia that regulates angiogenic factors. Two potent angiogenic factors - vascular endothelial growth factor (VEGF) and erythropoietin (Epo) - are regulated by transcription factors called hypoxia-inducible factors (HIFs). Several pathways that regulate the HIFs under hypoxic conditions are described. Then, we review the mechanisms, that is, involvement of VEGF and Epo, in pathological angiogenesis in the retina and describe supporting experimental data obtained from model animals, in addition to human clinical data. We also discuss how hypoxia regulates vascular development in the retina.

AB - Angiogenesis is regulated by the balance of angiogenic and anti-angiogenic factors through multiple pathways. In this article, we focus on hypoxia that regulates angiogenic factors. Two potent angiogenic factors - vascular endothelial growth factor (VEGF) and erythropoietin (Epo) - are regulated by transcription factors called hypoxia-inducible factors (HIFs). Several pathways that regulate the HIFs under hypoxic conditions are described. Then, we review the mechanisms, that is, involvement of VEGF and Epo, in pathological angiogenesis in the retina and describe supporting experimental data obtained from model animals, in addition to human clinical data. We also discuss how hypoxia regulates vascular development in the retina.

UR - http://www.scopus.com/inward/record.url?scp=85079822323&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85079822323&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-374203-2.00122-6

DO - 10.1016/B978-0-12-374203-2.00122-6

M3 - Chapter

AN - SCOPUS:85079822323

SN - 9780123741981

SP - 88

EP - 92

BT - Encyclopedia of the Eye

PB - Elsevier

ER -

Angiogenesis in response to hypoxia

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this