Animal models of vascular dementia

Translational potential at the present time and in 2050

Hidekazu Tomimoto, Hideaki Wakita

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Vascular dementia is a heterogeneous syndrome, and includes subcortical ischemic vascular dementia. For translational research, subcortical ischemic vascular dementia is an appropriate target since this is the most prevalent subtype and exhibits relatively uniform clinical and neuropathological changes. These changes consist of hypertensive arteriolar changes, lacunar infarctions, hypertensive hemorrhage and white matter lesions. Among various species, rodents are most frequently used, but their small volume of white matter may impede analysis of white matter lesions. Primate models have a larger volume, but the degree of white matter lesions is inconsistent. Animal models should accommodate the effect of aging and comorbidities, and in the case of primate models, low accessibility should be overcome by repeated and quantitative examinations using modern neuroimaging techniques and functional measures, especially for memory and motor function. There is no model that replicates all features of subcortical ischemic vascular dementia and, therefore, rodent and primate models should be selected appropriately for translational research.

Original languageEnglish
Pages (from-to)163-172
Number of pages10
JournalFuture Neurology
Volume9
Issue number2
DOIs
Publication statusPublished - 01-01-2014

Fingerprint

Vascular Dementia
Animal Models
Primates
Translational Medical Research
Rodentia
Lacunar Stroke
Functional Neuroimaging
Comorbidity
Hemorrhage
White Matter

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

@article{ffee64c8a152426fa755176eb6eefad5,
title = "Animal models of vascular dementia: Translational potential at the present time and in 2050",
abstract = "Vascular dementia is a heterogeneous syndrome, and includes subcortical ischemic vascular dementia. For translational research, subcortical ischemic vascular dementia is an appropriate target since this is the most prevalent subtype and exhibits relatively uniform clinical and neuropathological changes. These changes consist of hypertensive arteriolar changes, lacunar infarctions, hypertensive hemorrhage and white matter lesions. Among various species, rodents are most frequently used, but their small volume of white matter may impede analysis of white matter lesions. Primate models have a larger volume, but the degree of white matter lesions is inconsistent. Animal models should accommodate the effect of aging and comorbidities, and in the case of primate models, low accessibility should be overcome by repeated and quantitative examinations using modern neuroimaging techniques and functional measures, especially for memory and motor function. There is no model that replicates all features of subcortical ischemic vascular dementia and, therefore, rodent and primate models should be selected appropriately for translational research.",
author = "Hidekazu Tomimoto and Hideaki Wakita",
year = "2014",
month = "1",
day = "1",
doi = "10.2217/fnl.13.71",
language = "English",
volume = "9",
pages = "163--172",
journal = "Future Neurology",
issn = "1479-6708",
publisher = "Future Medicine Ltd.",
number = "2",

}

Animal models of vascular dementia : Translational potential at the present time and in 2050. / Tomimoto, Hidekazu; Wakita, Hideaki.

In: Future Neurology, Vol. 9, No. 2, 01.01.2014, p. 163-172.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Animal models of vascular dementia

T2 - Translational potential at the present time and in 2050

AU - Tomimoto, Hidekazu

AU - Wakita, Hideaki

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Vascular dementia is a heterogeneous syndrome, and includes subcortical ischemic vascular dementia. For translational research, subcortical ischemic vascular dementia is an appropriate target since this is the most prevalent subtype and exhibits relatively uniform clinical and neuropathological changes. These changes consist of hypertensive arteriolar changes, lacunar infarctions, hypertensive hemorrhage and white matter lesions. Among various species, rodents are most frequently used, but their small volume of white matter may impede analysis of white matter lesions. Primate models have a larger volume, but the degree of white matter lesions is inconsistent. Animal models should accommodate the effect of aging and comorbidities, and in the case of primate models, low accessibility should be overcome by repeated and quantitative examinations using modern neuroimaging techniques and functional measures, especially for memory and motor function. There is no model that replicates all features of subcortical ischemic vascular dementia and, therefore, rodent and primate models should be selected appropriately for translational research.

AB - Vascular dementia is a heterogeneous syndrome, and includes subcortical ischemic vascular dementia. For translational research, subcortical ischemic vascular dementia is an appropriate target since this is the most prevalent subtype and exhibits relatively uniform clinical and neuropathological changes. These changes consist of hypertensive arteriolar changes, lacunar infarctions, hypertensive hemorrhage and white matter lesions. Among various species, rodents are most frequently used, but their small volume of white matter may impede analysis of white matter lesions. Primate models have a larger volume, but the degree of white matter lesions is inconsistent. Animal models should accommodate the effect of aging and comorbidities, and in the case of primate models, low accessibility should be overcome by repeated and quantitative examinations using modern neuroimaging techniques and functional measures, especially for memory and motor function. There is no model that replicates all features of subcortical ischemic vascular dementia and, therefore, rodent and primate models should be selected appropriately for translational research.

UR - http://www.scopus.com/inward/record.url?scp=84895810055&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84895810055&partnerID=8YFLogxK

U2 - 10.2217/fnl.13.71

DO - 10.2217/fnl.13.71

M3 - Review article

VL - 9

SP - 163

EP - 172

JO - Future Neurology

JF - Future Neurology

SN - 1479-6708

IS - 2

ER -