Anti-annexin V antibodies and digital ischemia in patients with scleroderma

Kazumitsu Sugiura, Yoshinao Muro

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)


Objective. To elucidate the frequency and clinical significance of anti- annexin V antibodies in patients with scleroderma. Methods. The study population consisted of 66 patients with scleroderma. Their sera were examined for IgG anti-annexin V antibodies by ELISA and immunoblotting. Results. IgG anti-annexin V antibodies were detected by ELISA in 12 patients (18.2%) with scleroderma. Anti-annexin V antibodies were associated with digital ischemia in the patients with scleroderma. Only one patient of the 12 had anticardiolipin antibodies. Although 6 patients with anti-annexin V antibodies were also examined for activated partial thromboplastin time (APTT), none showed prolonged APTT. No IgG anti-annexin V antibodies were detected by immunoblotting. Conclusion. Anti-annexin V antibodies in scleroderma are related to digital ischemia. These antibodies may be associated with the pathogenesis of vascular involvement in scleroderma.

Original languageEnglish
Pages (from-to)2168-2172
Number of pages5
JournalJournal of Rheumatology
Issue number10
Publication statusPublished - 27-10-1999
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Rheumatology
  • Immunology


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