Anti-dementia activity of nobiletin, a citrus flavonoid: A review of animal studies

Akira Nakajima, Yasushi Ohizumi, Kiyofumi Yamada

Research output: Contribution to journalReview articlepeer-review

66 Citations (Scopus)

Abstract

Alzheimer's disease (AD), the most common form of dementia among the elderly, is characterized by the progressive decline of cognitive function and has a detrimental impact worldwide. Despite intensive laboratory and clinical research over the last three decades, pharmacological options for the prevention and effective long-term treatment of AD are not currently available. Consequently, successful therapeutic and preventive treatments for AD are needed. When researching materials from natural resources having anti-dementia drug activity, we identified nobiletin, a polymethoxylated flavone from the peel of Citrus depressa. Nobiletin exhibited memory-improving effects in various animal models of dementia and exerted a wide range of beneficial effects against pathological features of AD including amyloid-β (Aβ) pathology, tau hyperphosphorylation, oxidative stress, cholinergic neurodegeneration and dysfunction of synaptic plasticity-related signaling, suggesting this natural compound could become a novel drug for the treatment and prevention of AD. Copyright

Original languageEnglish
Pages (from-to)75-82
Number of pages8
JournalClinical Psychopharmacology and Neuroscience
Volume12
Issue number2
DOIs
Publication statusPublished - 08-2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Pharmacology (medical)

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