Anticancer Effects of Adriamycin-Loaded Hydroxyapatite Implants Determined in a Swarm Rat Chondrosarcoma Model

Keiko Yamamura, Takashi Osada, Toshitaka Nabeshima, Hisashi Iwata, Toshihisa Yotsuyanagi

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We investigated the antitumor effects of adriamycin (ADR)-loaded hydroxyapatite (HAP) beads in a Swarm rat chondrosarcoma model. When one ADR-loaded HAP bead (ADR: 0.8 mg/bead) was implanted into the central portion of a rat bearing tumor, the ADR-loaded HAP beads showed good therapeutic effects, increasing the life span (ILS) by 90%. Significantly, leukopenia and diarrhea were not observed. These results suggest that HAP delivery offers an interesting and a potentially effective method.

Original languageEnglish
Pages (from-to)289-291
Number of pages3
JournalThe Japanese Journal of Pharmacology
Issue number3
Publication statusPublished - 01-01-1994
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Pharmacology

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