Anticancer Effects of Adriamycin-Loaded Hydroxyapatite Implants Determined in a Swarm Rat Chondrosarcoma Model

Keiko Yamamura, Takashi Osada, Toshitaka Nabeshima, Hisashi Iwata, Toshihisa Yotsuyanagi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We investigated the antitumor effects of adriamycin (ADR)-loaded hydroxyapatite (HAP) beads in a Swarm rat chondrosarcoma model. When one ADR-loaded HAP bead (ADR: 0.8 mg/bead) was implanted into the central portion of a rat bearing tumor, the ADR-loaded HAP beads showed good therapeutic effects, increasing the life span (ILS) by 90%. Significantly, leukopenia and diarrhea were not observed. These results suggest that HAP delivery offers an interesting and a potentially effective method.

Original languageEnglish
Pages (from-to)289-291
Number of pages3
JournalThe Japanese Journal of Pharmacology
Volume65
Issue number3
DOIs
Publication statusPublished - 01-01-1994
Externally publishedYes

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Chondrosarcoma
Durapatite
Doxorubicin
Leukopenia
Therapeutic Uses
Diarrhea
Neoplasms

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Yamamura, Keiko ; Osada, Takashi ; Nabeshima, Toshitaka ; Iwata, Hisashi ; Yotsuyanagi, Toshihisa. / Anticancer Effects of Adriamycin-Loaded Hydroxyapatite Implants Determined in a Swarm Rat Chondrosarcoma Model. In: The Japanese Journal of Pharmacology. 1994 ; Vol. 65, No. 3. pp. 289-291.
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Anticancer Effects of Adriamycin-Loaded Hydroxyapatite Implants Determined in a Swarm Rat Chondrosarcoma Model. / Yamamura, Keiko; Osada, Takashi; Nabeshima, Toshitaka; Iwata, Hisashi; Yotsuyanagi, Toshihisa.

In: The Japanese Journal of Pharmacology, Vol. 65, No. 3, 01.01.1994, p. 289-291.

Research output: Contribution to journalArticle

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