Anticoagulant-induced pseudothrombocytopenia occurring after transcatheter arterial embolization for hepatocellular carcinoma

Takeshi Yoshikawa; Kayo Nakanishi; Tsutomu Maruta; Daisuke Takenaka; Shozo Hirota; Shinichi Matsumoto; Katsuyasu Saigo; Yoshiharu Ohno; Masahiko Fujii; Kazuro Sugimura

doi:10.1093/jjco/hyl054

Anticoagulant-induced pseudothrombocytopenia occurring after transcatheter arterial embolization for hepatocellular carcinoma

Takeshi Yoshikawa, Kayo Nakanishi, Tsutomu Maruta, Daisuke Takenaka, Shozo Hirota, Shinichi Matsumoto, Katsuyasu Saigo, Yoshiharu Ohno, Masahiko Fujii, Kazuro Sugimura

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Pseudothrombocytopenia (PTCP) is the in vitro phenomenon of anticoagulant-activated platelet agglutination that results in spuriously low platelet counts. We report the case of a 65-year-old man with EDTA- and sodium citrate-dependent PTCP occurring after transcatheter arterial embolization (TAE) for hepatocellular carcinoma (HCC) due to hepatitis C cirrhosis. Invasion of the portal and hepatic veins by HCC formed severe trans-tumoral arterio-venous shunts that were effectively treated by TAE. Two days after the therapy, PTCP was seen on blood count and continued for 4 months. The patient received unnecessary treatment for disseminated intravascular coagulation (DIC) until the diagnosis of PTCP was established. PTCP is a rare complication but should be considered after TAE for HCC; lack of recognition may lead the physician to misdiagnosis and patient mismanagement.

Original language	English
Pages (from-to)	527-531
Number of pages	5
Journal	Japanese journal of clinical oncology
Volume	36
Issue number	8
DOIs	https://doi.org/10.1093/jjco/hyl054
Publication status	Published - 08-2006
Externally published	Yes

All Science Journal Classification (ASJC) codes

Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/jjco/hyl054

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title = "Anticoagulant-induced pseudothrombocytopenia occurring after transcatheter arterial embolization for hepatocellular carcinoma",

abstract = "Pseudothrombocytopenia (PTCP) is the in vitro phenomenon of anticoagulant-activated platelet agglutination that results in spuriously low platelet counts. We report the case of a 65-year-old man with EDTA- and sodium citrate-dependent PTCP occurring after transcatheter arterial embolization (TAE) for hepatocellular carcinoma (HCC) due to hepatitis C cirrhosis. Invasion of the portal and hepatic veins by HCC formed severe trans-tumoral arterio-venous shunts that were effectively treated by TAE. Two days after the therapy, PTCP was seen on blood count and continued for 4 months. The patient received unnecessary treatment for disseminated intravascular coagulation (DIC) until the diagnosis of PTCP was established. PTCP is a rare complication but should be considered after TAE for HCC; lack of recognition may lead the physician to misdiagnosis and patient mismanagement.",

author = "Takeshi Yoshikawa and Kayo Nakanishi and Tsutomu Maruta and Daisuke Takenaka and Shozo Hirota and Shinichi Matsumoto and Katsuyasu Saigo and Yoshiharu Ohno and Masahiko Fujii and Kazuro Sugimura",

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doi = "10.1093/jjco/hyl054",

language = "English",

volume = "36",

pages = "527--531",

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issn = "0368-2811",

publisher = "Oxford University Press",

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T1 - Anticoagulant-induced pseudothrombocytopenia occurring after transcatheter arterial embolization for hepatocellular carcinoma

AU - Yoshikawa, Takeshi

AU - Nakanishi, Kayo

AU - Maruta, Tsutomu

AU - Takenaka, Daisuke

AU - Hirota, Shozo

AU - Matsumoto, Shinichi

AU - Saigo, Katsuyasu

AU - Ohno, Yoshiharu

AU - Fujii, Masahiko

AU - Sugimura, Kazuro

PY - 2006/8

Y1 - 2006/8

N2 - Pseudothrombocytopenia (PTCP) is the in vitro phenomenon of anticoagulant-activated platelet agglutination that results in spuriously low platelet counts. We report the case of a 65-year-old man with EDTA- and sodium citrate-dependent PTCP occurring after transcatheter arterial embolization (TAE) for hepatocellular carcinoma (HCC) due to hepatitis C cirrhosis. Invasion of the portal and hepatic veins by HCC formed severe trans-tumoral arterio-venous shunts that were effectively treated by TAE. Two days after the therapy, PTCP was seen on blood count and continued for 4 months. The patient received unnecessary treatment for disseminated intravascular coagulation (DIC) until the diagnosis of PTCP was established. PTCP is a rare complication but should be considered after TAE for HCC; lack of recognition may lead the physician to misdiagnosis and patient mismanagement.

AB - Pseudothrombocytopenia (PTCP) is the in vitro phenomenon of anticoagulant-activated platelet agglutination that results in spuriously low platelet counts. We report the case of a 65-year-old man with EDTA- and sodium citrate-dependent PTCP occurring after transcatheter arterial embolization (TAE) for hepatocellular carcinoma (HCC) due to hepatitis C cirrhosis. Invasion of the portal and hepatic veins by HCC formed severe trans-tumoral arterio-venous shunts that were effectively treated by TAE. Two days after the therapy, PTCP was seen on blood count and continued for 4 months. The patient received unnecessary treatment for disseminated intravascular coagulation (DIC) until the diagnosis of PTCP was established. PTCP is a rare complication but should be considered after TAE for HCC; lack of recognition may lead the physician to misdiagnosis and patient mismanagement.

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DO - 10.1093/jjco/hyl054

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AN - SCOPUS:33750105331

SN - 0368-2811

VL - 36

SP - 527

EP - 531

JO - Japanese journal of clinical oncology

JF - Japanese journal of clinical oncology

IS - 8

ER -

Anticoagulant-induced pseudothrombocytopenia occurring after transcatheter arterial embolization for hepatocellular carcinoma

Abstract

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