Anticonvulsant effects of new morphinan derivatives

Hyoung Chun Kim, Toshitaka Nabeshima, Wang Kee Jhoo, Kwang Ho Ko, Won Ki Kim, Eun Joo Shin, Minkyoung Cho, Phil Ho Lee

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

We synthesized a series of compounds that are modified in positions 3 and 17 of the morphinan ring system, with the intention of developing ideal anticonvulsant agents. We examined the effects of these compounds on kainic acid (KA)-induced seizures, and on locomotor patterns in rats. We found that compounds 5, 6, and 8 exhibit novel anticonvulsant effects, with negligible psychotropic effects.

Original languageEnglish
Pages (from-to)1651-1654
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume11
Issue number13
DOIs
Publication statusPublished - 09-07-2001

Fingerprint

Morphinans
Anticonvulsants
Derivatives
Kainic Acid
Rats
Seizures

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Kim, H. C., Nabeshima, T., Jhoo, W. K., Ko, K. H., Kim, W. K., Shin, E. J., ... Lee, P. H. (2001). Anticonvulsant effects of new morphinan derivatives. Bioorganic and Medicinal Chemistry Letters, 11(13), 1651-1654. https://doi.org/10.1016/S0960-894X(01)00262-1
Kim, Hyoung Chun ; Nabeshima, Toshitaka ; Jhoo, Wang Kee ; Ko, Kwang Ho ; Kim, Won Ki ; Shin, Eun Joo ; Cho, Minkyoung ; Lee, Phil Ho. / Anticonvulsant effects of new morphinan derivatives. In: Bioorganic and Medicinal Chemistry Letters. 2001 ; Vol. 11, No. 13. pp. 1651-1654.
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Kim, HC, Nabeshima, T, Jhoo, WK, Ko, KH, Kim, WK, Shin, EJ, Cho, M & Lee, PH 2001, 'Anticonvulsant effects of new morphinan derivatives', Bioorganic and Medicinal Chemistry Letters, vol. 11, no. 13, pp. 1651-1654. https://doi.org/10.1016/S0960-894X(01)00262-1

Anticonvulsant effects of new morphinan derivatives. / Kim, Hyoung Chun; Nabeshima, Toshitaka; Jhoo, Wang Kee; Ko, Kwang Ho; Kim, Won Ki; Shin, Eun Joo; Cho, Minkyoung; Lee, Phil Ho.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 11, No. 13, 09.07.2001, p. 1651-1654.

Research output: Contribution to journalArticle

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