Anticonvulsant effects of new morphinan derivatives

Hyoung Chun Kim, Toshitaka Nabeshima, Wang Kee Jhoo, Kwang Ho Ko, Won Ki Kim, Eun Joo Shin, Minkyoung Cho, Phil Ho Lee

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23 Citations (Scopus)

Abstract

We synthesized a series of compounds that are modified in positions 3 and 17 of the morphinan ring system, with the intention of developing ideal anticonvulsant agents. We examined the effects of these compounds on kainic acid (KA)-induced seizures, and on locomotor patterns in rats. We found that compounds 5, 6, and 8 exhibit novel anticonvulsant effects, with negligible psychotropic effects.

Original languageEnglish
Pages (from-to)1651-1654
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume11
Issue number13
DOIs
Publication statusPublished - 09-07-2001

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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  • Cite this

    Kim, H. C., Nabeshima, T., Jhoo, W. K., Ko, K. H., Kim, W. K., Shin, E. J., Cho, M., & Lee, P. H. (2001). Anticonvulsant effects of new morphinan derivatives. Bioorganic and Medicinal Chemistry Letters, 11(13), 1651-1654. https://doi.org/10.1016/S0960-894X(01)00262-1