TY - JOUR
T1 - Anticonvulsant effects of new morphinan derivatives
AU - Kim, Hyoung Chun
AU - Nabeshima, Toshitaka
AU - Jhoo, Wang Kee
AU - Ko, Kwang Ho
AU - Kim, Won Ki
AU - Shin, Eun Joo
AU - Cho, Minkyoung
AU - Lee, Phil Ho
N1 - Funding Information:
This work was supported by the BK 21 project and a grant (1998-012-F00014) from the Korea Research Foundation, Republic of Korea.
PY - 2001/7/9
Y1 - 2001/7/9
N2 - We synthesized a series of compounds that are modified in positions 3 and 17 of the morphinan ring system, with the intention of developing ideal anticonvulsant agents. We examined the effects of these compounds on kainic acid (KA)-induced seizures, and on locomotor patterns in rats. We found that compounds 5, 6, and 8 exhibit novel anticonvulsant effects, with negligible psychotropic effects.
AB - We synthesized a series of compounds that are modified in positions 3 and 17 of the morphinan ring system, with the intention of developing ideal anticonvulsant agents. We examined the effects of these compounds on kainic acid (KA)-induced seizures, and on locomotor patterns in rats. We found that compounds 5, 6, and 8 exhibit novel anticonvulsant effects, with negligible psychotropic effects.
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U2 - 10.1016/S0960-894X(01)00262-1
DO - 10.1016/S0960-894X(01)00262-1
M3 - Article
C2 - 11425529
AN - SCOPUS:0035833111
SN - 0960-894X
VL - 11
SP - 1651
EP - 1654
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 13
ER -