Anticonvulsant effects of new morphinan derivatives

Hyoung Chun Kim; Toshitaka Nabeshima; Wang Kee Jhoo; Kwang Ho Ko; Won Ki Kim; Eun Joo Shin; Minkyoung Cho; Phil Ho Lee

doi:10.1016/S0960-894X(01)00262-1

Anticonvulsant effects of new morphinan derivatives

Hyoung Chun Kim, Toshitaka Nabeshima, Wang Kee Jhoo, Kwang Ho Ko, Won Ki Kim, Eun Joo Shin, Minkyoung Cho, Phil Ho Lee

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

We synthesized a series of compounds that are modified in positions 3 and 17 of the morphinan ring system, with the intention of developing ideal anticonvulsant agents. We examined the effects of these compounds on kainic acid (KA)-induced seizures, and on locomotor patterns in rats. We found that compounds 5, 6, and 8 exhibit novel anticonvulsant effects, with negligible psychotropic effects.

Original language	English
Pages (from-to)	1651-1654
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	11
Issue number	13
DOIs	https://doi.org/10.1016/S0960-894X(01)00262-1
Publication status	Published - 09-07-2001
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(01)00262-1

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title = "Anticonvulsant effects of new morphinan derivatives",

abstract = "We synthesized a series of compounds that are modified in positions 3 and 17 of the morphinan ring system, with the intention of developing ideal anticonvulsant agents. We examined the effects of these compounds on kainic acid (KA)-induced seizures, and on locomotor patterns in rats. We found that compounds 5, 6, and 8 exhibit novel anticonvulsant effects, with negligible psychotropic effects.",

author = "Kim, \{Hyoung Chun\} and Toshitaka Nabeshima and Jhoo, \{Wang Kee\} and Ko, \{Kwang Ho\} and Kim, \{Won Ki\} and Shin, \{Eun Joo\} and Minkyoung Cho and Lee, \{Phil Ho\}",

note = "Funding Information: This work was supported by the BK 21 project and a grant (1998-012-F00014) from the Korea Research Foundation, Republic of Korea.",

year = "2001",

month = jul,

day = "9",

doi = "10.1016/S0960-894X(01)00262-1",

language = "English",

volume = "11",

pages = "1651--1654",

journal = "Bioorganic and Medicinal Chemistry Letters",

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publisher = "Elsevier Ltd",

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TY - JOUR

T1 - Anticonvulsant effects of new morphinan derivatives

AU - Kim, Hyoung Chun

AU - Nabeshima, Toshitaka

AU - Jhoo, Wang Kee

AU - Ko, Kwang Ho

AU - Kim, Won Ki

AU - Shin, Eun Joo

AU - Cho, Minkyoung

AU - Lee, Phil Ho

N1 - Funding Information: This work was supported by the BK 21 project and a grant (1998-012-F00014) from the Korea Research Foundation, Republic of Korea.

PY - 2001/7/9

Y1 - 2001/7/9

N2 - We synthesized a series of compounds that are modified in positions 3 and 17 of the morphinan ring system, with the intention of developing ideal anticonvulsant agents. We examined the effects of these compounds on kainic acid (KA)-induced seizures, and on locomotor patterns in rats. We found that compounds 5, 6, and 8 exhibit novel anticonvulsant effects, with negligible psychotropic effects.

AB - We synthesized a series of compounds that are modified in positions 3 and 17 of the morphinan ring system, with the intention of developing ideal anticonvulsant agents. We examined the effects of these compounds on kainic acid (KA)-induced seizures, and on locomotor patterns in rats. We found that compounds 5, 6, and 8 exhibit novel anticonvulsant effects, with negligible psychotropic effects.

UR - https://www.scopus.com/pages/publications/0035833111

UR - https://www.scopus.com/inward/citedby.url?scp=0035833111&partnerID=8YFLogxK

U2 - 10.1016/S0960-894X(01)00262-1

DO - 10.1016/S0960-894X(01)00262-1

M3 - Article

C2 - 11425529

AN - SCOPUS:0035833111

SN - 0960-894X

VL - 11

SP - 1651

EP - 1654

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 13

ER -

Anticonvulsant effects of new morphinan derivatives

Abstract

All Science Journal Classification (ASJC) codes

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