Antigen expression associated with lymph node metastasis in gastric adenocarcinomas

Shi‐Nong ‐N Wang, Motohiro Miyauchi, Nobuko Koshikawa, Koshi Maruyama, Tetsuo Kubota, Keiji Miura, Yoshikazu Kurosawa, Akira Awaya, Yoshiyuki Kanai

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27 Citations (Scopus)

Abstract

A total of 100 gastric adenocarcinomas, comprising 50 cases with lymph node metastasis and 50 cases without lymph node metastasis, were examined for immunohistochemical reactivity with the monoclonal antibody to urokinase‐type plasminogen activator (u‐PA), Lex related 4C9 antigen, Jun, or to nucleobindin (Nuc). In tumors with lymph node metastasis, 41 (82%) were positive for u‐PA and 28 (56%) were positive for Nuc. In tumors without lymph node metastasis, 26 (52%) were positive for u‐PA and five (10%) were positive for Nuc. The percentage of cases positive for u‐PA or Nuc was significantly higher in tumors with lymph node metastasis than that in tumors without lymph node metastasis (P < 0.01). The expression of u‐PA was found to be significantly correlated with that of Nuc (P < 0.001), mode of infiltrative growth (P < 0.05), depth of invasion (P < 0.01), and grade of lymphatic invasion (P < 0.01). However, the expression of Nuc was found to be significantly correlated with the expression of Jun (P< 0.05), depth of invasion (P < 0.01), and grade of lymphatic invasion (P < 0.001). These results suggest that immunohistochemical examination for the expression of u‐PA and Nuc in tumor cells may help evaluate the potential of adenocarcinomas of the stomach for lymph node metastasis.

Original languageEnglish
Pages (from-to)844-849
Number of pages6
JournalPathology International
Volume44
Issue number12
DOIs
Publication statusPublished - 12-1994

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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  • Cite this

    Wang, SN. N., Miyauchi, M., Koshikawa, N., Maruyama, K., Kubota, T., Miura, K., Kurosawa, Y., Awaya, A., & Kanai, Y. (1994). Antigen expression associated with lymph node metastasis in gastric adenocarcinomas. Pathology International, 44(12), 844-849. https://doi.org/10.1111/j.1440-1827.1994.tb01682.x