Antinociceptive action of tizanidine in mice and rats

Tsutomu Kameyama, Toshitaka Nabeshima, Akira Sugimoto, Kiyoshi Matsuno, Shigeyuki Yamada

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)


The antinociceptive action of tizanidine [5-chloro-(2-imidazolin-2-yl-amino)-2,1,3-benzothiadiazole], a centrally acting muscle relaxant, was evaluated after subcutaneous or peroral administration in mice and rats. Tizanidine strongly inhibited the writhing response induced by acetic acid, phenyl-p-benzoquinone and acetylcholine in mice, and its potency was found to be greater than that of morphine. Tizanidine showed antinociceptive action like morphine not only in tail pressure and electrical stimulation tests in mice but also in tail-flick tests in mice and rats. The antinociceptive action of tizanidine was unaffected by pretreatment with naloxone. These findings suggest that tizanidine develops relatively strong antinociceptive action by a nonopioid mechanism.

Original languageEnglish
Pages (from-to)93-96
Number of pages4
JournalNaunyn-Schmiedeberg's Archives of Pharmacology
Issue number2
Publication statusPublished - 01-08-1985
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology


Dive into the research topics of 'Antinociceptive action of tizanidine in mice and rats'. Together they form a unique fingerprint.

Cite this