Antithrombotic effect of geniposide and genipin in the mouse thrombosis model

Y. Suzuki, K. Kondo, Y. Ikeda, K. Umemura

Research output: Contribution to journalArticle

128 Citations (Scopus)

Abstract

Geniposide is one of the constituents of Gardenia fruit (Gardenia jasminoides Ellis, Rubiaceae), which has been used in traditional medicine. Although its anti-inflammatory and antithrombotic effects have been reported, the way it acts is still unclear. We have investigated the effects of geniposide and its metabolite genipin on thrombogenesis and platelet aggregation. In an in vivo model, geniposide and genipin significantly (P < 0.05) prolonged the time required for thrombotic occlusion induced by photochemical reaction in the mouse femoral artery. In an in vitro study, both geniposide and genipin inhibited collagen-induced, but did not inhibit arachidonate-induced, mouse platelet aggregation. However aspirin, a cyclooxygenase inhibitor, inhibited arachidonate-induced platelet aggregation but only partially inhibited the collagen-induced one. We also showed, by measuring PLA2-catalyzed arachidonic acid release, that geniposide inhibited phospholipase A2 (PLA2) activity. We conclude that geniposide showed an antithrombotic effect in vivo due to the suppression of platelet aggregation. PLA2 inhibition by geniposide is one possible anti-platelet mechanism.

Original languageEnglish
Pages (from-to)807-810
Number of pages4
JournalPlanta Medica
Volume67
Issue number9
DOIs
Publication statusPublished - 2001

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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