Antitumor effect of combination chemotherapy with TNP-470 and CDDP on intracranial tumor transplanted in rats. Histological changes of intratumoral tissue

N. Isobe; T. Uozumi; K. Kurisu; K. Kawamoto; K. Sudo; K. Sugiyama; S. Monden; T. Nishi; K. Harada; T. Inoue; T. Sadatomo; S. Hama

Antitumor effect of combination chemotherapy with TNP-470 and CDDP on intracranial tumor transplanted in rats. Histological changes of intratumoral tissue

N. Isobe, T. Uozumi, K. Kurisu, K. Kawamoto, K. Sudo, K. Sugiyama, S. Monden, T. Nishi, K. Harada, T. Inoue, T. Sadatomo, S. Hama

Spine and Spinal Cord Surgery

Research output: Contribution to journal › Article › peer-review

Abstract

Previously we reported antitumor effect of TNP-470 on intracranial tumor, which is 9-L gliosarcoma, transplanted in rats. This time we examined antitumor effect of the combination with TNP-470 and CDDP, compared with the administration of the single agent. TNP-470 made the ischemic changes in tumor tissue, and CDDP brought about coagulation necrosis. The combination chemotherapy elongated the survival periods of the transplanted rats without severe side effects. Therefore this treatment was considered to be effective for the treatment of glial tumors. But we should look into the administration dose and methods of antitumor agents.

Original language	English
Pages (from-to)	440-441
Number of pages	2
Journal	Biotherapy
Volume	9
Issue number	3
Publication status	Published - 1995

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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title = "Antitumor effect of combination chemotherapy with TNP-470 and CDDP on intracranial tumor transplanted in rats. Histological changes of intratumoral tissue",

abstract = "Previously we reported antitumor effect of TNP-470 on intracranial tumor, which is 9-L gliosarcoma, transplanted in rats. This time we examined antitumor effect of the combination with TNP-470 and CDDP, compared with the administration of the single agent. TNP-470 made the ischemic changes in tumor tissue, and CDDP brought about coagulation necrosis. The combination chemotherapy elongated the survival periods of the transplanted rats without severe side effects. Therefore this treatment was considered to be effective for the treatment of glial tumors. But we should look into the administration dose and methods of antitumor agents.",

author = "N. Isobe and T. Uozumi and K. Kurisu and K. Kawamoto and K. Sudo and K. Sugiyama and S. Monden and T. Nishi and K. Harada and T. Inoue and T. Sadatomo and S. Hama",

year = "1995",

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Antitumor effect of combination chemotherapy with TNP-470 and CDDP on intracranial tumor transplanted in rats. Histological changes of intratumoral tissue. / Isobe, N.; Uozumi, T.; Kurisu, K.; Kawamoto, K.; Sudo, K.; Sugiyama, K.; Monden, S.; Nishi, T.; Harada, K.; Inoue, T.; Sadatomo, T.; Hama, S.

In: Biotherapy, Vol. 9, No. 3, 1995, p. 440-441.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Antitumor effect of combination chemotherapy with TNP-470 and CDDP on intracranial tumor transplanted in rats. Histological changes of intratumoral tissue

AU - Isobe, N.

AU - Uozumi, T.

AU - Kurisu, K.

AU - Kawamoto, K.

AU - Sudo, K.

AU - Sugiyama, K.

AU - Monden, S.

AU - Nishi, T.

AU - Harada, K.

AU - Inoue, T.

AU - Sadatomo, T.

AU - Hama, S.

PY - 1995

Y1 - 1995

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AB - Previously we reported antitumor effect of TNP-470 on intracranial tumor, which is 9-L gliosarcoma, transplanted in rats. This time we examined antitumor effect of the combination with TNP-470 and CDDP, compared with the administration of the single agent. TNP-470 made the ischemic changes in tumor tissue, and CDDP brought about coagulation necrosis. The combination chemotherapy elongated the survival periods of the transplanted rats without severe side effects. Therefore this treatment was considered to be effective for the treatment of glial tumors. But we should look into the administration dose and methods of antitumor agents.

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VL - 9

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JF - Biotherapy

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