Antitumor effect of combination chemotherapy with TNP-470 and CDDP on intracranial tumor transplanted in rats. Histological changes of intratumoral tissue

N. Isobe; T. Uozumi; K. Kurisu; K. Kawamoto; K. Sudo; K. Sugiyama; S. Monden; T. Nishi; K. Harada; T. Inoue; T. Sadatomo; S. Hama

Antitumor effect of combination chemotherapy with TNP-470 and CDDP on intracranial tumor transplanted in rats. Histological changes of intratumoral tissue

N. Isobe, T. Uozumi, K. Kurisu, K. Kawamoto, K. Sudo, K. Sugiyama, S. Monden, T. Nishi, K. Harada, T. Inoue, T. Sadatomo, S. Hama

Research output: Contribution to journal › Article › peer-review

Abstract

Previously we reported antitumor effect of TNP-470 on intracranial tumor, which is 9-L gliosarcoma, transplanted in rats. This time we examined antitumor effect of the combination with TNP-470 and CDDP, compared with the administration of the single agent. TNP-470 made the ischemic changes in tumor tissue, and CDDP brought about coagulation necrosis. The combination chemotherapy elongated the survival periods of the transplanted rats without severe side effects. Therefore this treatment was considered to be effective for the treatment of glial tumors. But we should look into the administration dose and methods of antitumor agents.

Original language	English
Pages (from-to)	440-441
Number of pages	2
Journal	Biotherapy
Volume	9
Issue number	3
Publication status	Published - 1995
Externally published	Yes

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

Cite this

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title = "Antitumor effect of combination chemotherapy with TNP-470 and CDDP on intracranial tumor transplanted in rats. Histological changes of intratumoral tissue",

abstract = "Previously we reported antitumor effect of TNP-470 on intracranial tumor, which is 9-L gliosarcoma, transplanted in rats. This time we examined antitumor effect of the combination with TNP-470 and CDDP, compared with the administration of the single agent. TNP-470 made the ischemic changes in tumor tissue, and CDDP brought about coagulation necrosis. The combination chemotherapy elongated the survival periods of the transplanted rats without severe side effects. Therefore this treatment was considered to be effective for the treatment of glial tumors. But we should look into the administration dose and methods of antitumor agents.",

author = "N. Isobe and T. Uozumi and K. Kurisu and K. Kawamoto and K. Sudo and K. Sugiyama and S. Monden and T. Nishi and K. Harada and T. Inoue and T. Sadatomo and S. Hama",

year = "1995",

language = "English",

volume = "9",

pages = "440--441",

journal = "Biotherapy",

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TY - JOUR

T1 - Antitumor effect of combination chemotherapy with TNP-470 and CDDP on intracranial tumor transplanted in rats. Histological changes of intratumoral tissue

AU - Isobe, N.

AU - Uozumi, T.

AU - Kurisu, K.

AU - Kawamoto, K.

AU - Sudo, K.

AU - Sugiyama, K.

AU - Monden, S.

AU - Nishi, T.

AU - Harada, K.

AU - Inoue, T.

AU - Sadatomo, T.

AU - Hama, S.

PY - 1995

Y1 - 1995

N2 - Previously we reported antitumor effect of TNP-470 on intracranial tumor, which is 9-L gliosarcoma, transplanted in rats. This time we examined antitumor effect of the combination with TNP-470 and CDDP, compared with the administration of the single agent. TNP-470 made the ischemic changes in tumor tissue, and CDDP brought about coagulation necrosis. The combination chemotherapy elongated the survival periods of the transplanted rats without severe side effects. Therefore this treatment was considered to be effective for the treatment of glial tumors. But we should look into the administration dose and methods of antitumor agents.

AB - Previously we reported antitumor effect of TNP-470 on intracranial tumor, which is 9-L gliosarcoma, transplanted in rats. This time we examined antitumor effect of the combination with TNP-470 and CDDP, compared with the administration of the single agent. TNP-470 made the ischemic changes in tumor tissue, and CDDP brought about coagulation necrosis. The combination chemotherapy elongated the survival periods of the transplanted rats without severe side effects. Therefore this treatment was considered to be effective for the treatment of glial tumors. But we should look into the administration dose and methods of antitumor agents.

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M3 - Article

AN - SCOPUS:0028904896

VL - 9

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EP - 441

JO - Biotherapy

JF - Biotherapy

SN - 0914-2223

IS - 3

ER -

Antitumor effect of combination chemotherapy with TNP-470 and CDDP on intracranial tumor transplanted in rats. Histological changes of intratumoral tissue

Abstract

All Science Journal Classification (ASJC) codes

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