Aortic valvular calcification predicts restenosis after implantation of drug-eluting stents in patients on chronic haemodialysis

Hideki Ishii, Yoshitake Kumada, Takanobu Toriyama, Toru Aoyama, Hiroshi Takahashi, Tetsuya Amano, Yoshinari Yasuda, Yukio Yuzawa, Syoichi Maruyama, Seiichi Matsuo, Tatsuaki Matsubara, Toyoaki Murohara

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background. Even in the drug-eluting stent (DES) era, the restenosis rate of the follow-up period after percutaneous coronary intervention (PCI) is higher in haemodialysis (HD) patients than in non-HD patients. Therefore, higher restenosis remains a clinical limitation in HD patients, and a simple clinical method to predict patients likely to have restenosis after stent implantation is attractive. The present study investigated the potential relationship between aortic valvular calcification (AVC) and angiographical restenosis at follow-up after DES implantation in patients on maintenance HD.Methods. In the study, 97 patients were enrolled. We prospectively performed echocardiography before elective PCI with DES implantation. Angiographic follow-up was scheduled between 6 and 8 months after PCI. Restenosis at follow-up was defined as a diameter stenosis of ≥50 by measuring quantitative coronary angiography.Results. Of the enrolled patients, 59 patients (60.8) had AVC. Complete angiographical follow-up was obtained in 86 patients (88.7). The angiographical restenosis rate during the follow-up period was 24.7 in patients with AVC and 8.9 in patients without AVC hazard ratio (HR) 3.36; 95 confidence interval (CI) 1.18-9.56, P = 0.023. Even after multivariate adjustment including covariates related to atherogenecity, AVC remained an independent predictor of restenosis after implanting DES (HR 3.83; 95 CI 1.14-12.9, P = 0.029). Late lumen loss suggesting neointimal growth after DES implantation was 0.28 ± 0.70 mm in the non-AVC group and 0.64 ± 0.90 mm in the AVC group (P = 0.013).Conclusions. AVC provides predictive information regarding DES implantation in patients on maintenance HD.

Original languageEnglish
Pages (from-to)1562-1567
Number of pages6
JournalNephrology Dialysis Transplantation
Volume24
Issue number5
DOIs
Publication statusPublished - 05-2009

All Science Journal Classification (ASJC) codes

  • Nephrology
  • Transplantation

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