Apo A-I and apo E concentrations in cerebrospinal fluids of patients with acute meningitis

Hua Song, Mitsuru Seishima, Kuniaki Saito, Satoshi Maeda, Masao Takemura, Akio Noma, Akira Kondo, Mitsuhisa Manabe, Katsuya Urakami, Kenji Nakashima

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11 Citations (Scopus)

Abstract

It has been demonstrated that apolipoproteins found in cerebrospinal fluid (CSF) play an important role in lipid metabolism in the central nervous system (CNS). Previously we reported that CSF apo A-I levels increased with the severity of neurological damage in poliovirus-infected macaques. In the present study, apo A-I was quantitatively analysed in CSF from patients with or without neurological diseases. In controls, CSF apo A-I level was significantly higher in males; 3.83 (0.40) mg/L, mean (SEM) (n = 19) compared with females, 2.42 (0.26) mg/L (n = 23, P < 0.05). CSF apo A-I concentrations in patients with acute meningitis increased at the active stage, 7.74 (1.78) mg/L (n = 10), but returned to basal concentrations at the convalescent stage 2.72 (0.38) mg/L (n = 10), while the CSF apo A-I level in patients with other neurological diseases remained in the same range as in controls. By contrast, CSF apo E was consistently elevated at either stage of acute meningitis. Furthermore, it was found that the levels of CSF apo A-I, but not of apo E, correlated positively with CSF albumin concentrations. These findings suggest that the CSF apo A-I and apo E have different origins and may play different roles in the lipoprotein metabolism in CNS.

Original languageEnglish
Pages (from-to)408-414
Number of pages7
JournalAnnals of Clinical Biochemistry
Volume35
Issue number3
DOIs
Publication statusPublished - 01-01-1998
Externally publishedYes

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Cerebrospinal fluid
Apolipoprotein A-I
Apolipoproteins E
Meningitis
Cerebrospinal Fluid
Neurology
Central Nervous System
Poliovirus
Apolipoproteins
Macaca
Lipid Metabolism
Metabolism
Lipoproteins
Albumins

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

Song, Hua ; Seishima, Mitsuru ; Saito, Kuniaki ; Maeda, Satoshi ; Takemura, Masao ; Noma, Akio ; Kondo, Akira ; Manabe, Mitsuhisa ; Urakami, Katsuya ; Nakashima, Kenji. / Apo A-I and apo E concentrations in cerebrospinal fluids of patients with acute meningitis. In: Annals of Clinical Biochemistry. 1998 ; Vol. 35, No. 3. pp. 408-414.
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abstract = "It has been demonstrated that apolipoproteins found in cerebrospinal fluid (CSF) play an important role in lipid metabolism in the central nervous system (CNS). Previously we reported that CSF apo A-I levels increased with the severity of neurological damage in poliovirus-infected macaques. In the present study, apo A-I was quantitatively analysed in CSF from patients with or without neurological diseases. In controls, CSF apo A-I level was significantly higher in males; 3.83 (0.40) mg/L, mean (SEM) (n = 19) compared with females, 2.42 (0.26) mg/L (n = 23, P < 0.05). CSF apo A-I concentrations in patients with acute meningitis increased at the active stage, 7.74 (1.78) mg/L (n = 10), but returned to basal concentrations at the convalescent stage 2.72 (0.38) mg/L (n = 10), while the CSF apo A-I level in patients with other neurological diseases remained in the same range as in controls. By contrast, CSF apo E was consistently elevated at either stage of acute meningitis. Furthermore, it was found that the levels of CSF apo A-I, but not of apo E, correlated positively with CSF albumin concentrations. These findings suggest that the CSF apo A-I and apo E have different origins and may play different roles in the lipoprotein metabolism in CNS.",
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Song, H, Seishima, M, Saito, K, Maeda, S, Takemura, M, Noma, A, Kondo, A, Manabe, M, Urakami, K & Nakashima, K 1998, 'Apo A-I and apo E concentrations in cerebrospinal fluids of patients with acute meningitis', Annals of Clinical Biochemistry, vol. 35, no. 3, pp. 408-414. https://doi.org/10.1177/000456329803500310

Apo A-I and apo E concentrations in cerebrospinal fluids of patients with acute meningitis. / Song, Hua; Seishima, Mitsuru; Saito, Kuniaki; Maeda, Satoshi; Takemura, Masao; Noma, Akio; Kondo, Akira; Manabe, Mitsuhisa; Urakami, Katsuya; Nakashima, Kenji.

In: Annals of Clinical Biochemistry, Vol. 35, No. 3, 01.01.1998, p. 408-414.

Research output: Contribution to journalArticle

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T1 - Apo A-I and apo E concentrations in cerebrospinal fluids of patients with acute meningitis

AU - Song, Hua

AU - Seishima, Mitsuru

AU - Saito, Kuniaki

AU - Maeda, Satoshi

AU - Takemura, Masao

AU - Noma, Akio

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AU - Manabe, Mitsuhisa

AU - Urakami, Katsuya

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