Apolipoprotein a2 isoforms in relation to the risk of myocardial infarction: A nested case-control analysis in the jphc study

Tomomi Kihara, Kazumasa Yamagishi, Kazufumi Honda, Ai Ikeda, Hiroshi Yatsuya, Isao Saito, Yoshihiro Kokubo, Taiki Yamaji, Taichi Shimazu, Norie Sawada, Motoki Iwasaki, Hiroyasu Iso, Shoichiro Tsugane

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Aim: The fact that low concentrations of high-density lipoprotein cholesterol are associated with the risk of car-diovascular disease is well known, but high-density lipoprotein metabolism has not been fully understood. Apoli-poprotein A2 (ApoA2) is the second-most dominant apolipoprotein of high-density lipoprotein. We tested the hypothesis that ApoA2 isoforms are inversely associated with myocardial infarction. Methods: We measured the plasma levels of three ApoA2 isoforms (ApoA2-ATQ/ATQ, ApoA2-ATQ/AT, ApoA2-AT/AT) in nested case-control study samples of 1:2 from the Japan Public Health-Center-based Study (JPHC Study): 106 myocardial infarction incidence cases and 212 controls. Results: ApoA2-AT/AT was inversely associated with risk of myocardial infarction, in a matched model (OR, 2.78; 95% Cl, 1.26-6.09 for lowest compared with the highest quartile), but its association was attenuated after adjustment for smoking only (OR=2.13; 95% Cl, 0.91-4.97) or drinking only (OR=2.11; 0.91-4.89), and the multivariable OR was 1.20 (95% Cl, 0.41-3.57). Neither ApoA2-ATQ/ATQ nor ApoA2-ATQ/AT was associ-ated with the risk of myocardial infarction. Conclusions Our nested case-control study did not show a significant association of ApoA2 isoforms with a risk of myocardial infarction.

Original languageEnglish
Pages (from-to)483-490
Number of pages8
JournalJournal of atherosclerosis and thrombosis
Issue number5
Publication statusPublished - 2021

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine
  • Biochemistry, medical


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