Application a response duration schedule in rats to evaluate drug-induced auditory impairment

Tsutomu Kameyama, Toshitaka Nabeshima, Kazuyuki Takahashi

Research output: Contribution to journalArticle

Abstract

Determination of auditory threshold was carried out under a response duration schedule of tone and/or light- dipper presentation. This schedule enabled an exact assessment of auditory sensitivity, since the direction and distance from rat to sound source were constant and the rat could thus acquire the conditioned behavior in a short time. The rat has to press the lever and hold it until a CS(tone and/or light) was presented. The animal could get water-reinforcement with release of the lever during the period of CS. The intensity of 3 KHz pure tone was reduced, from 110 dB (starting point), by 2 dB steps in each trial, until the subject made 3 non-response trials(i.e., no dipper approach within 0.7 sec after the tone onset) among 5 trials. The highest tone intensity among non-response trials was taken as the threshold. The auditory sensitivity of the rats with cotton-stuffed ears and the pierced eardrums decreased about 10 and 20 dB, respectively. The auditory sensitivity in rats was decreased by administration of streptomycin sulfate(SM), 300 mg/kg/day, i.m., in combination with ethacrynic acid(EA), 50 mg/kg/day, p.o., for forty days and in combination with EA, 100 mg/ kg/day, p.o. for ten days. The auditory sensitivity was not influenced by administration of SM, 300 mg/kg/ day, i.m., for forty days.

Original languageEnglish
Pages (from-to)419-426
Number of pages8
JournalFolia Pharmacologica Japonica
Volume74
Issue number3
DOIs
Publication statusPublished - 01-01-1978

Fingerprint

Appointments and Schedules
Ethacrynic Acid
Streptomycin
Pharmaceutical Preparations
Auditory Threshold
Sigmodontinae
Light
Tympanic Membrane
Ear
Water

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

@article{1d647b8e7c714293b2e70933df83b111,
title = "Application a response duration schedule in rats to evaluate drug-induced auditory impairment",
abstract = "Determination of auditory threshold was carried out under a response duration schedule of tone and/or light- dipper presentation. This schedule enabled an exact assessment of auditory sensitivity, since the direction and distance from rat to sound source were constant and the rat could thus acquire the conditioned behavior in a short time. The rat has to press the lever and hold it until a CS(tone and/or light) was presented. The animal could get water-reinforcement with release of the lever during the period of CS. The intensity of 3 KHz pure tone was reduced, from 110 dB (starting point), by 2 dB steps in each trial, until the subject made 3 non-response trials(i.e., no dipper approach within 0.7 sec after the tone onset) among 5 trials. The highest tone intensity among non-response trials was taken as the threshold. The auditory sensitivity of the rats with cotton-stuffed ears and the pierced eardrums decreased about 10 and 20 dB, respectively. The auditory sensitivity in rats was decreased by administration of streptomycin sulfate(SM), 300 mg/kg/day, i.m., in combination with ethacrynic acid(EA), 50 mg/kg/day, p.o., for forty days and in combination with EA, 100 mg/ kg/day, p.o. for ten days. The auditory sensitivity was not influenced by administration of SM, 300 mg/kg/ day, i.m., for forty days.",
author = "Tsutomu Kameyama and Toshitaka Nabeshima and Kazuyuki Takahashi",
year = "1978",
month = "1",
day = "1",
doi = "10.1254/fpj.74.419",
language = "English",
volume = "74",
pages = "419--426",
journal = "Folia Pharmacologica Japonica",
issn = "0015-5691",
publisher = "Japanese Pharmacological Society",
number = "3",

}

Application a response duration schedule in rats to evaluate drug-induced auditory impairment. / Kameyama, Tsutomu; Nabeshima, Toshitaka; Takahashi, Kazuyuki.

In: Folia Pharmacologica Japonica, Vol. 74, No. 3, 01.01.1978, p. 419-426.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Application a response duration schedule in rats to evaluate drug-induced auditory impairment

AU - Kameyama, Tsutomu

AU - Nabeshima, Toshitaka

AU - Takahashi, Kazuyuki

PY - 1978/1/1

Y1 - 1978/1/1

N2 - Determination of auditory threshold was carried out under a response duration schedule of tone and/or light- dipper presentation. This schedule enabled an exact assessment of auditory sensitivity, since the direction and distance from rat to sound source were constant and the rat could thus acquire the conditioned behavior in a short time. The rat has to press the lever and hold it until a CS(tone and/or light) was presented. The animal could get water-reinforcement with release of the lever during the period of CS. The intensity of 3 KHz pure tone was reduced, from 110 dB (starting point), by 2 dB steps in each trial, until the subject made 3 non-response trials(i.e., no dipper approach within 0.7 sec after the tone onset) among 5 trials. The highest tone intensity among non-response trials was taken as the threshold. The auditory sensitivity of the rats with cotton-stuffed ears and the pierced eardrums decreased about 10 and 20 dB, respectively. The auditory sensitivity in rats was decreased by administration of streptomycin sulfate(SM), 300 mg/kg/day, i.m., in combination with ethacrynic acid(EA), 50 mg/kg/day, p.o., for forty days and in combination with EA, 100 mg/ kg/day, p.o. for ten days. The auditory sensitivity was not influenced by administration of SM, 300 mg/kg/ day, i.m., for forty days.

AB - Determination of auditory threshold was carried out under a response duration schedule of tone and/or light- dipper presentation. This schedule enabled an exact assessment of auditory sensitivity, since the direction and distance from rat to sound source were constant and the rat could thus acquire the conditioned behavior in a short time. The rat has to press the lever and hold it until a CS(tone and/or light) was presented. The animal could get water-reinforcement with release of the lever during the period of CS. The intensity of 3 KHz pure tone was reduced, from 110 dB (starting point), by 2 dB steps in each trial, until the subject made 3 non-response trials(i.e., no dipper approach within 0.7 sec after the tone onset) among 5 trials. The highest tone intensity among non-response trials was taken as the threshold. The auditory sensitivity of the rats with cotton-stuffed ears and the pierced eardrums decreased about 10 and 20 dB, respectively. The auditory sensitivity in rats was decreased by administration of streptomycin sulfate(SM), 300 mg/kg/day, i.m., in combination with ethacrynic acid(EA), 50 mg/kg/day, p.o., for forty days and in combination with EA, 100 mg/ kg/day, p.o. for ten days. The auditory sensitivity was not influenced by administration of SM, 300 mg/kg/ day, i.m., for forty days.

UR - http://www.scopus.com/inward/record.url?scp=0018099989&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018099989&partnerID=8YFLogxK

U2 - 10.1254/fpj.74.419

DO - 10.1254/fpj.74.419

M3 - Article

C2 - 669486

AN - SCOPUS:0018099989

VL - 74

SP - 419

EP - 426

JO - Folia Pharmacologica Japonica

JF - Folia Pharmacologica Japonica

SN - 0015-5691

IS - 3

ER -