Application of a shuttle avoidance schedule in rats to evaluate a drug-induced auditory irnpairment

Tsutomu Kameyama, Toshitaka Nabeshima, Jiro Ito

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In attempts to study drug-induced auditory impairment we measured the auditory threshold in rats, using the shuttle box method. The auditory threshold with physical impairment of ears was also measured. The sensitivity of the rats to the auditory response was decreased to about 15dB in cotton-stuffed ears and to about 20dB in pierced eardrums. In this experiment, we used drugs known to be ototoxic; dihydrostreptomycin sulfate, kanamycin sulfate, neomycin sulfate and ethacrynic acid. With successive administration of each drug, the auditory sensitivity in rats decreased. This shuttle box method is easily facilitated and the auditory threshold of many rats can be measured over a short period. This approach may be a useful method for screening ototoxic drugs.

Original languageEnglish
Pages (from-to)15-25
Number of pages11
JournalFolia Pharmacologica Japonica
Volume77
Issue number1
DOIs
Publication statusPublished - 01-01-1981
Externally publishedYes

Fingerprint

Auditory Threshold
Appointments and Schedules
Pharmaceutical Preparations
Ear
Dihydrostreptomycin Sulfate
Ethacrynic Acid
Tympanic Membrane
Preclinical Drug Evaluations
Kanamycin
Neomycin

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

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Application of a shuttle avoidance schedule in rats to evaluate a drug-induced auditory irnpairment. / Kameyama, Tsutomu; Nabeshima, Toshitaka; Ito, Jiro.

In: Folia Pharmacologica Japonica, Vol. 77, No. 1, 01.01.1981, p. 15-25.

Research output: Contribution to journalArticle

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