Application of microRNA in the treatment and diagnosis of cervical cancer

Kouji Banno; Miho Iida; Megumi Yanokura; Iori Kisu; Kanako Nakamura; Masataka Adachi; Takashi Iwata; Kyoko Tanaka; Daisuke Aoki

doi:10.1007/978-3-319-05134-5_7

Application of microRNA in the treatment and diagnosis of cervical cancer

Kouji Banno
, Miho Iida
, Megumi Yanokura
, Iori Kisu
, Kanako Nakamura
, Masataka Adachi
, Takashi Iwata
, Kyoko Tanaka
, Daisuke Aoki

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

MicroRNAs (miRNAs) are small non-coding RNA molecules of 20-23 nucleotides that regulate gene expression by binding to complementary mRNA sequences. Aberrant miRNA expression is implicated in carcinogenesis and malignancy of cancer. miRNAs involved in carcinogenesis are broadly classified into oncogenic and tumor suppressor miRNAs, and overexpression of oncogenic miRNAs and decreased expression of tumor suppressor miRNAs are found in cancer cells. Recent studies using miRNAs with different expression patterns between normal and cancer tissues have proposed use of miRNAs as biomarkers for cancer diagnosis and as treatment targets. In cervical cancer, miRNAs may be useful for onset detection, diagnosis and treatment. Here, we review the potential clinical applications of miRNAs for diagnosis and as a therapeutic strategy in cervical cancer.

Original language	English
Title of host publication	MicroRNA Targeted Cancer Therapy
Publisher	Springer International Publishing
Pages	129-137
Number of pages	9
ISBN (Electronic)	9783319051345
ISBN (Print)	3319051334, 9783319051338
DOIs	https://doi.org/10.1007/978-3-319-05134-5_7
Publication status	Published - 01-02-2014
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

General Medicine

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10.1007/978-3-319-05134-5_7

Cite this

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abstract = "MicroRNAs (miRNAs) are small non-coding RNA molecules of 20-23 nucleotides that regulate gene expression by binding to complementary mRNA sequences. Aberrant miRNA expression is implicated in carcinogenesis and malignancy of cancer. miRNAs involved in carcinogenesis are broadly classified into oncogenic and tumor suppressor miRNAs, and overexpression of oncogenic miRNAs and decreased expression of tumor suppressor miRNAs are found in cancer cells. Recent studies using miRNAs with different expression patterns between normal and cancer tissues have proposed use of miRNAs as biomarkers for cancer diagnosis and as treatment targets. In cervical cancer, miRNAs may be useful for onset detection, diagnosis and treatment. Here, we review the potential clinical applications of miRNAs for diagnosis and as a therapeutic strategy in cervical cancer.",

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AU - Banno, Kouji

AU - Iida, Miho

AU - Yanokura, Megumi

AU - Kisu, Iori

AU - Nakamura, Kanako

AU - Adachi, Masataka

AU - Iwata, Takashi

AU - Tanaka, Kyoko

AU - Aoki, Daisuke

PY - 2014/2/1

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AB - MicroRNAs (miRNAs) are small non-coding RNA molecules of 20-23 nucleotides that regulate gene expression by binding to complementary mRNA sequences. Aberrant miRNA expression is implicated in carcinogenesis and malignancy of cancer. miRNAs involved in carcinogenesis are broadly classified into oncogenic and tumor suppressor miRNAs, and overexpression of oncogenic miRNAs and decreased expression of tumor suppressor miRNAs are found in cancer cells. Recent studies using miRNAs with different expression patterns between normal and cancer tissues have proposed use of miRNAs as biomarkers for cancer diagnosis and as treatment targets. In cervical cancer, miRNAs may be useful for onset detection, diagnosis and treatment. Here, we review the potential clinical applications of miRNAs for diagnosis and as a therapeutic strategy in cervical cancer.

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M3 - Chapter

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BT - MicroRNA Targeted Cancer Therapy

PB - Springer International Publishing

ER -

Application of microRNA in the treatment and diagnosis of cervical cancer

Abstract

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All Science Journal Classification (ASJC) codes

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