Arachidonic or docosahexaenoic acid diet prevents memory impairment in Tg2576 mice

Takashi Hosono, Akihiro Mouri, Kazuchika Nishitsuji, Cha Gyun Jung, Masanori Kontani, Hisanori Tokuda, Hiroshi Kawashima, Hiroshi Shibata, Toshiharu Suzuki, Toshitaka Nabehsima, Makoto Michikawa

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

It is believed that the amyloid β-protein (Aβ) plays a causative role in the development of Alzheimer's disease (AD). The amyloid-β protein precursor (AβPP), a substrate of Aβ, and β-secretase and β-secretase complex proteins, which process AβPP to generate Aβ, are all membrane proteins. Thus, it is reasonable to assume that alterations in brain lipid metabolism modulate AβPP and/or Aβ metabolism. However, the role of cellular polyunsaturated fatty acids in AβPP processing has not been completely understood yet.We report here that 4 months of treatment of Tg2576 mice with an arachidonic acid (ARA)-or a docosahexaenoic acid (DHA)-containing (ARA+ or DHA+) diet prevented memory impairment at 13 months of age. Although, AβPP processing to generate soluble AβPP and induce Aβ synthesis was enhanced, Aβ1-42/Aβ1-40 ratio decreased in 14-monthold Tg2576 mice fed with the ARA+ or DHA+ diet. The ARA+ or DHA+ diet did not alter the AβPP levels and the expression levels of Aβ-degrading enzymes. In cortical primary neuron cultures, ARA or DHA treatment also increased soluble AβPP and Aβ1-40 levels, and decreased Aβ 1-42/Aβ 1-40 ratio, which are similar to what were observed in Tg2576 mice fed with ARA+ or DHA+ diet. These findings suggest that not only the DHA+ diet, but also the ARA+ diet could prevent cognitive dysfunction in Tg2576 mice through the alteration of AβPP processing.

Original languageEnglish
Pages (from-to)149-162
Number of pages14
JournalJournal of Alzheimer's Disease
Volume48
Issue number1
DOIs
Publication statusPublished - 28-08-2015

Fingerprint

Docosahexaenoic Acids
Amyloid beta-Protein Precursor
Arachidonic Acid
Diet
Amyloid Precursor Protein Secretases
Serum Amyloid A Protein
Staphylococcal Protein A
Unsaturated Fatty Acids
Lipid Metabolism
Alzheimer Disease
Membrane Proteins
Neurons
Brain
Enzymes

All Science Journal Classification (ASJC) codes

  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Hosono, T., Mouri, A., Nishitsuji, K., Jung, C. G., Kontani, M., Tokuda, H., ... Michikawa, M. (2015). Arachidonic or docosahexaenoic acid diet prevents memory impairment in Tg2576 mice. Journal of Alzheimer's Disease, 48(1), 149-162. https://doi.org/10.3233/JAD-150341
Hosono, Takashi ; Mouri, Akihiro ; Nishitsuji, Kazuchika ; Jung, Cha Gyun ; Kontani, Masanori ; Tokuda, Hisanori ; Kawashima, Hiroshi ; Shibata, Hiroshi ; Suzuki, Toshiharu ; Nabehsima, Toshitaka ; Michikawa, Makoto. / Arachidonic or docosahexaenoic acid diet prevents memory impairment in Tg2576 mice. In: Journal of Alzheimer's Disease. 2015 ; Vol. 48, No. 1. pp. 149-162.
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Hosono, T, Mouri, A, Nishitsuji, K, Jung, CG, Kontani, M, Tokuda, H, Kawashima, H, Shibata, H, Suzuki, T, Nabehsima, T & Michikawa, M 2015, 'Arachidonic or docosahexaenoic acid diet prevents memory impairment in Tg2576 mice', Journal of Alzheimer's Disease, vol. 48, no. 1, pp. 149-162. https://doi.org/10.3233/JAD-150341

Arachidonic or docosahexaenoic acid diet prevents memory impairment in Tg2576 mice. / Hosono, Takashi; Mouri, Akihiro; Nishitsuji, Kazuchika; Jung, Cha Gyun; Kontani, Masanori; Tokuda, Hisanori; Kawashima, Hiroshi; Shibata, Hiroshi; Suzuki, Toshiharu; Nabehsima, Toshitaka; Michikawa, Makoto.

In: Journal of Alzheimer's Disease, Vol. 48, No. 1, 28.08.2015, p. 149-162.

Research output: Contribution to journalArticle

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AU - Hosono, Takashi

AU - Mouri, Akihiro

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AU - Jung, Cha Gyun

AU - Kontani, Masanori

AU - Tokuda, Hisanori

AU - Kawashima, Hiroshi

AU - Shibata, Hiroshi

AU - Suzuki, Toshiharu

AU - Nabehsima, Toshitaka

AU - Michikawa, Makoto

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